How transcription factors program chromatin—Lessons from studies of the regulation of myeloid-specific genes
Abstract
Hematopoietic stem cells exhibit a multi-lineage gene expression program, and this expression program is either maintained when these cells self-renew, or re-programmed when they differentiate. Both processes require the regulated expression of sequence-specific transcription factors and their interaction with the epigenetic regulatory machinery which programs the chromatin of hematopoietic genes in a cell type specific fashion. This article describes recent findings on the complexity of these molecular interactions and their consequences with respect to the regulation of cell fate decisions. We also describe recent findings from studies of genes expressed in the myeloid lineage (Pu.1 and csf1r) which highlight some of the molecular principles governing cell fate decisions at the epigenetic level.
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PU.1 action is important or indispensable for sustained generation of all known hematopoietic precursors with lymphoid developmental potentials.
“its action is also important or indispensable for sustained generation of all known hematopoietic precursors that have lymphoid developmental potentials (1–9).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [6]
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References 99 · Cited by 27
- Authors
- Bonifer, C., Hoogenkamp, M., Krysinska, H., & Tagoh, H.
- Affiliations
- University of Leeds (GB)
- Corresponding author
- Bonifer, Constanze
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 20
- Issue
- 4
- Pages
- 257-263
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W1989716013
- Cited by
- 27
- References
- 99
- Citations by year
- 2026: 1 · 2020: 1 · 2019: 2 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Immunology (publishedVersion)
- PubMed (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Kay Kendall Leukaemia Fund
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- transcription factors, chromatin regulation, hematopoietic stem cells, epigenetic regulation, cell fate determination, hematopoietic differentiation, self-renewal, PU.1, CSF1R, lineage-specific gene expression
- MeSH terms
- Proto-Oncogene Protein Spi-1, Animals, Cell Differentiation, Chromatin, Gene Expression Regulation, Humans, Proto-Oncogene Proteins, Transcription Factors, Trans-Activators, Receptor, Macrophage Colony-Stimulating Factor, Cell Lineage, Gene Silencing, Myeloid Cells
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