Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System
Open accessAbstract
The interaction of inorganic nanoparticles and many biological fluids often withstands the formation of a Protein Corona enveloping the nanoparticle. This Protein Corona provides the biological identity to the nanoparticle that the immune system will detect. The formation of this Protein Corona depends not only on the composition of the nanoparticle, its size, shape, surface state and exposure time, but also on the type of media, nanoparticle to protein ratio and the presence of ions and other molecular species that interfere in the interaction between proteins and nanoparticles. This has important implications on immune safety, biocompatibility and the use of nanoparticles in medicine.
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Protein corona presents a major obstacle to bench-to-bedside translation of targeted drug delivery systems, severely affecting targeting yields and directing unfavorable biodistribution.
“Protein corona presents a major obstacle to bench-to-bedside translation of targeted drug delivery systems, severely affecting targeting yields and directing unfavorable biodistribution.”
From Brain-targeted drug delivery by manipulating protein corona functions (2019) · cites this paper as [9]
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References 117 · Cited by 263
- Authors
- Barbero, F., Russo, L., Vitali, M., Piella, J., Salvo, I., Borrajo, M. L., Busquets-Fité, M., Grandori, R., Bastús, N. G., Casals, E., & Puntes, V.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Vall d'Hebron Institut de Recerca (ES)
- University of Milano-Bicocca (IT)
- Consejo Superior de Investigaciones Científicas (ES)
- ORCID
- Venue
- Seminars in Immunology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 34
- Pages
- 52-60
- ISSN
- 1044-5323 (ISSN-L)
- OpenAlex
- W2766753913
- Cited by
- 263
- References
- 117
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 19 · 2023: 42 · 2022: 41 · 2021: 55 · 2020: 43 · 2019: 22 · 2018: 5
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Seminars in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System University of Turin (University of Turin) (submittedVersion, other-oa)
- BOA (University of Milano-Bicocca) (submittedVersion, cc-by-nc-nd)
- Funders
- Spanish Monasterio de Ciencia e Innovación (MAT2015-70725-R)
- Catalan Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR) (2014-SGR-612)
- Pandora European Training Network (GA-671881)
- Spanish MINECO through the Severo Ochoa Centres of Excellence Programme (SEV-2013-0295)
- MINECO through the Ramon y Cajal program (RYC-2012-10991)
- Ministry of Health of the Government of Catalonia through PERIS (SLT002/16/00312)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- protein corona, nanoparticle-protein interactions, immune system, nanoparticle biocompatibility, nanoparticle toxicity, nanoparticle size and shape, surface functionalization, ionic strength effects, biological fluids
- MeSH terms
- Protein Corona, Animals, Biocompatible Materials, Humans, Immune System, Particle Size, Nanomedicine, Nanoparticles
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