The DOI matches its Crossref record; 224 of the 230 references it cites were found in a registry or an index.
REM sleep dysregulation in depression: State of the art
Abstract
Disturbances of sleep are typical for most depressed patients and belong to the core symptoms of the disorder. Since the 1960s polysomnographic sleep research has demonstrated that besides disturbances of sleep continuity, depression is associated with altered sleep architecture, i.e., a decrease in slow wave sleep (SWS) production and disturbed rapid eye movement (REM) sleep regulation. Shortened REM latency (i.e., the interval between sleep onset and the occurrence of the first REM period), increased REM sleep duration and increased REM density (i.e., the frequency of rapid eye movements per REM period) have been considered as biological markers of depression which might predict relapse and recurrence. High risk studies including healthy relatives of patients with depression demonstrate that REM sleep alterations may precede the clinical expression of depression and may thus be useful in identifying subjects at high risk for the illness. Several models have been developed to explain REM sleep abnormalities in depression, like the cholinergic-aminergic imbalance model or chronobiologically inspired theories, which are reviewed in this overview. Moreover, REM sleep alterations have been recently considered not only as biological "scars" but as true endophenotypes of depression. This review discusses the genetic, neurochemical and neurobiological factors that have been implicated to play a role in the complex relationships between REM sleep and depression. We hypothesize on the one hand that REM sleep dysregulation in depression may be linked to a genetic predisposition/vulnerability to develop the illness; on the other hand it is conceivable that REM sleep disinhibition in itself is a part of a maladaptive stress reaction with increased allostatic load. We also discuss whether the REM sleep changes in depression may contribute themselves to the development of central symptoms of depression such as cognitive distortions including negative self-esteem and the overnight consolidation of negatively toned emotional memories.
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In the citing paper
“Actually, the role of REM sleep in the mood regulation is somehow controversial since several studies found that this stage has a depressant effect (Palagini et al., 2013).”
From The Functional Role of Dreaming in Emotional Processes (2019) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“Depressed subjects also show reductions in slow wave (stage 3/4) sleep, increases in rapid eye movement (REM) sleep, including a shorter latency to REM initiation, a protraction of the REM sleep period, and increases in REM density (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“However, exogenously-induced inflammation using both endotoxin and IFN-α also led to a suppression of REM sleep (Mullington et al., 2000; Raison et al., 2010), which is the opposite of changes observed in depressed patients (Palagini et al., 2013; Riemann et al., 2001; Tsuno et al., 2005).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
In the citing paper
“and remediate one of the sleep problems influenced by inflammation (Palagini et al., 2013; Riemann et al., 2001)”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Palagini et al., 2013
Citations
Cites
Items 201–224 of 224
Shaffery, J. P., López, J., Bissette, G., & Roffwarg, H. P. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.051 · Cited by 28
Somoza, E. C., & Mossman, D. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90036-2 · Cited by 28
Application of EEG Sleep for the Differential Diagnosis and Treatment of Affective Disorders*
Kupfer, D. J. (1978) · Pharmacopsychiatry · doi:10.1055/s-0028-1094559 · Cited by 27
Physostigmine-induced epinephrine release in patients with affective disorder
Janowsky, D. S., Sc, R., Ziegler, M. G., Gillin, J. C., Huey, L. Y., & Rausch, J. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.7.919 · Cited by 27
Germain, A. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.10.1856 · Cited by 27
Howland, R. H. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy1049 · Cited by 26
Serendipity Strikes Again: Scopolamine as an Antidepressant Agent in Bipolar Depressed Patients
Janowsky, D. S. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0239-6 · Cited by 26
Brainstem structures responsible for paradoxical sleep onset and maintenance.
Luppi, P., Gervasoni, D., Boissard, R., Verret, L., Goutagny, R., Peyron, C., Salvert, D., Léger, L., Barbagli, B., & Fort, P. (2004) · PubMed · Cited by 25
The link between sleep and depression: The effects of antidepressants on EEG sleep
van Bemmel, A. L. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00003-2 · Cited by 25
Variation in Process S: Effects on Sleep Continuity and Architecture
Knowles, J. B., Coulter, M., Wahnon, S., Reitz, W. E., & MacLean, A. (1990) · SLEEP · doi:10.1093/sleep/13.2.97 · Cited by 20
Are biological rhythms disturbed in depression?
Zerssen, D. V., Dirlich, G., Doerr, P., Emrich, H. M., Lund, R., & Ploog, D. W. (1985) · PubMed · Cited by 19
Biological markers of melancholia and reclassification of depressive disorders.
Jf, G. (1982) · PubMed · Cited by 18
Giles, D. E., Etzel, B. A., & Biggs, M. M. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90147-w · Cited by 16
Longterm evolution of sleep in depression
Riemann, D. W., Lauer, C. J., Hohagen, F., & Berger, T. (1991) · Max Planck Institute for Plasma Physics · Cited by 14
Self-citationThe role of emotional brain processing during sleep in depression
Edge, L. (2010) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/j.1365-2850.2010.01598.x · Cited by 14
Cholinergic-adrenergic balance: Part 2. Relationship between drug sensitivity and personality
Fritze, J., Sofic, E., Müller, T. D., Pfüller, H., Lanczik, M., & Riederer, P. F. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90005-p · Cited by 14
REM sleep abnormalities in depression: a test of the phase-advance hypothesis.
Jb, K., MacLean, A. W., & Cairns, J. (1982) · PubMed · Cited by 12
Cholinergic drugs as diagnostic and therapeutic tools in affective disorders
Berger, T., Riemann, D. W., & Krieg, C. (1991) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1991.tb03110.x · Cited by 11
Self-citationAnsseau, M., VONFRENCKELL, R., Franck, G., REYNOLDSIII, C., & Kupfer, D. J. (1987) · Revue d Electroencé phalographie et de Neurophysiologie Clinique · doi:10.1016/s0370-4475(87)80087-4 · Cited by 10
Catecholamines and Depression: A Physiological Theory of Depression
Kicey, C. A. (1974) · AJN American Journal of Nursing · doi:10.2307/3423203 · Cited by 7
[Biological models of depression: effect of antidepressants on sleep].
Viot-Blanc, V. (1995) · PubMed · Cited by 5
Early Onset and Accumulation of Rem Sleep in Depression: A Study of the Phase-Advance Hypothesis
Zammit, G. K., Pollak, C. P., Rosenbaum, A. H., & Roth, T. G. (1990) · Chronobiology International · doi:10.3109/07420529009056968 · Cited by 4
[Sleep electroencephalography in depression and mental disorders with depressive comorbidity].
Eiber, R., & Escande, M. (2000) · PubMed · Cited by 2
Flagged first, then by citations
6 of the 230 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Veitch, 2001, Slow waves in sleep are altered by paroxetine and nefazodone in depressed patients, J Psychopharm, 15, A18
- Papousek, 1975, Chronobiological aspects of cyclothymia, Fortschr Neurol Psychiatr Grenzgeb, 43, 381
- Ellman, 1991, REM deprivation: a review, 327
Cited by
Sorted by citations
The role of sleep in emotional brain function
Goldstein, A. N., & Walker, M. P. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153716 · Cited by 1,052
“…entrance into REM sleep, (2) increased intensity of REM sleep (indexed in the number of rapid eye movements), and (3) longer duration of REM sleep periods (Armitage 2007, Buysse 2004, Franzen & Buysse 2008, Gottesmann & Gottesman 2007, Harvey et al 2003, Palagini et al 2013, Tsuno et al 2005).”
BackgroundSleep and mental disorders: a meta-analysis of polysomnographic research
Baglioni, C., Nanovska, S., Regen, W., Spiegelhalder, K., Feige, B., Nissen, C., Reynolds, C. F., & Riemann, D. (2016) · Psychological Bulletin · doi:10.1037/bul0000053 · Cited by 1,074
Self-citationSleep disturbance and psychiatric disorders
Freeman, D., Sheaves, B., Waite, F., Harvey, A. G., & Harrison, P. J. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30136-x · Cited by 843
Sleep disorders in the elderly: a growing challenge
Gulia, K. K., & Kumar, V. M. (2018) · Psychogeriatrics · doi:10.1111/psyg.12319 · Cited by 584
Sleep changes in the disorder of insomnia: a meta-analysis of polysomnographic studies
Baglioni, C., Regen, W., Teghen, A., Spiegelhalder, K., Feige, B., Nissen, C., & Riemann, D. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.04.001 · Cited by 386
Self-citation
Metadata
- Authors
- Palagini, L., Baglioni, C., Ciapparelli, A., Gemignani, A., & Riemann, D.
- Affiliations
- University of Pisa (IT)
- University of Freiburg (DE)
- Corresponding author
- Palagini, Laura
- Venue
- Sleep Medicine Reviews
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 17
- Issue
- 5
- Pages
- 377-390
- ISSN
- 1087-0792 (ISSN-L)
- OpenAlex
- W2022024201
- Cited by
- 513
- References
- 230
- Citations by year
- 2026: 53 · 2025: 59 · 2024: 42 · 2023: 61 · 2022: 35 · 2021: 45 · 2020: 31 · 2019: 38 · 2018: 35 · 2017: 24 · 2016: 31 · 2015: 30 · 2014: 18 · 2013: 10
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sleep Medicine Reviews (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- REM sleep, depression, REM latency, REM density, REM sleep duration, sleep architecture, slow-wave sleep, depression biomarkers, endophenotypes, chronobiology, genetic susceptibility, allostatic load, maladaptive stress response, emotional memory consolidation, cognitive distortions, recurrence prediction
- MeSH terms
- Antidepressive Agents, Brain, Depression, Humans, Sleep Deprivation, Sleep Wake Disorders, Sleep, REM, Stress, Psychological
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