CoChat
Sign Up
Cited by 545Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleepSleep and related disorders

The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.

Phenotypic approaches to obstructive sleep apnoea – New pathways for targeted therapy

Open access
Eckert, Danny J.·2018·Sleep Medicine Reviews
DOI 10.1016/j.smrv.2016.12.003
Open this paper in CoChat — free account

Abstract

People develop obstructive sleep apnoea (OSA) for different reasons. The ability to understand these reasons, easily identify them in individual patients, and develop therapies that target one or more of these reasons are the keys to unlocking new approaches for the treatment of OSA. In line with this approach, recent advances in OSA pathogenesis using upper airway and respiratory phenotyping techniques have identified four key causes of OSA. A narrow or collapsible upper airway ('impaired anatomy') is the primary cause. However, the anatomical contribution to OSA varies substantially. Indeed, impairment in pharyngeal anatomy can be modest and in many patients (∼20%), pharyngeal collapsibility asleep is not different to people without OSA. Thus, non-anatomical factors or 'phenotypes' that modulate pharyngeal patency are crucial determinants of OSA for many people. These include impairment in pharyngeal dilator muscle control and function during sleep, increased propensity for awakening during airway narrowing (low respiratory arousal threshold) and respiratory control instability (high loop gain). Each phenotype is a potential therapeutic target. This review summarises the recent advances in the understanding of OSA pathogenesis according to a phenotypic approach, emerging tools to identify the phenotypes, and potential new therapeutic pathways and interventions to treat this common disorder.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.smrv.2016.12.003

Cites

115 of 115 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 115 references

Cited by

Sorted by citations

Items 301–400 of 540

Related

See all

Metadata

Authors
Eckert, D. J.
Affiliations
UNSW Sydney (AU)
Corresponding author
Eckert, Danny J.
ORCID
Eckert, Danny J.
Venue
Sleep Medicine Reviews
Publisher
Elsevier BV
Published
2018-02
Volume
37
Pages
45-59
ISSN
1087-0792 (ISSN-L)
DOI
10.1016/j.smrv.2016.12.003
OpenAlex
W2565665126
Cited by
545
References
115
Citations by year
2026: 72 · 2025: 62 · 2024: 56 · 2023: 71 · 2022: 72 · 2021: 77 · 2020: 49 · 2019: 43 · 2018: 25
FWCI
3.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Sleep Medicine Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
  • UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
Funders
National Health and Medical Research Council (1049814, 1060992)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
obstructive sleep apnea, OSA pathogenesis, upper airway anatomy, pharyngeal collapsibility, loop gain, targeted therapy, upper airway imaging
MeSH terms
Arousal, Humans, Pharynx, Phenotype, Sleep, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, Precision Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review