Orthostatic intolerance and the headache patient
Abstract
Orthostatic intolerance (OI) refers to a group of clinical conditions, including postural orthostatic tachycardia syndrome (POTS) and neurally mediated hypotension (NMH), in which symptoms worsen with upright posture and are ameliorated by recumbence. The main symptoms of chronic orthostatic intolerance syndromes include light-headedness, syncope or near syncope, blurring of vision, headaches, problems with short-term memory and concentration, fatigue, intolerance of low impact exercise, palpitations, chest pain, diaphoresis, tremulousness, dyspnea or air hunger, nausea, and vomiting. This review discusses what is known about the pathophysiology of this disorder, potential treatments, and understanding its role in the patient with chronic headache pain.
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A frequently described comorbidity in POTS patients is migraine, as well as other chronic headache types.
“A frequently described comorbidity in POTS patients is migraine, as well as other chronic headache types (6,65,72,73).”
From Postural Orthostatic Tachycardia Syndrome (2019) · cites this paper as [72]
Orthostatic headaches occur commonly in POTS and other orthostatic intolerance syndromes.
“Orthostatic headaches are common in POTS and other forms of orthostatic intolerance (Mack et al., 2010).”
From Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome (2018) · cites this paper as Mack et al., 2010
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References 84 · Cited by 47
- Authors
- Mack, K. J., Johnson, J. N., & Rowe, P. C.
- Affiliations
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Corresponding author
- Mack, Kenneth J.
- Venue
- Seminars in Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 17
- Issue
- 2
- Pages
- 109-116
- ISSN
- 1071-9091 (ISSN-L)
- OpenAlex
- W2071226736
- Cited by
- 47
- References
- 84
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Seminars in Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- orthostatic intolerance, postural orthostatic tachycardia syndrome, chronic headache, headache pathophysiology, syncope, lightheadedness, pediatric patients
- MeSH terms
- Adolescent, Child, Headache, Humans, Orthostatic Intolerance
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