Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis

Boyle, Monica, Wong, Chihunt, Rocha, Michael, Jones, D. Leanne·2007·Cell Stem Cell
DOI 10.1016/j.stem.2007.08.002

Cited by (268)

Items 201–268 of 268

  1. Ageing of the spermatogenesis system
    S. T. Zahidov, А.Н. Хохлов, Ekaterina A. Malolina, Andrey Yu. Kulibin, Т. Л. Маршак · 2010 · Biology Bulletin
  2. Changes of Wnt/β-catenin signalling, BMP2, and BMP4 in the jejunum during ageing in rats
    Yaoyan Dun, Jing Chen, Jie Liu, Yuhui Guo, Changcheng Zhang, Ding Yuan · 2020 · Arab Journal of Gastroenterology
  3. A meiotic switch in lysosome activity supports spermatocyte development in young flies but collapses with age
    Tyler J. Butsch, Olga S. Dubuisson, Alyssa E. Johnson, K. Adam Bohnert · 2022 · iScience
  4. Simultaneous control of stemness and differentiation by the transcription factor Escargot in adult stem cells: How can we tease them apart?
    Mariano Loza‐Coll, D. Leanne Jones · 2016 · Fly
  5. Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis
    Xueqian Zhuang, Qing Wang, Simon Joost, Alexander Ferrena, David T. Humphreys, Zhuxuan Li, Melissa Blum, Klavdija Bastl, Selena Ding, Yuna Landais et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Spermatogenesis
    Fiona Messer, Helen White‐Cooper, Marc Amoyel · 2025 · Elsevier eBooks
  7. Drosophila ovarian stem cell niche ageing involves coordinated changes in transcription and alternative splicing
    Dilamm Even Ros, Judit Huertas Romero, Miriam Marín-Menguiano, Gretel Nusspaumer, Miguel Borge de Prada, Manuel Irimia, Federico Zurita, Acaimo González‐Reyes · 2025 · Nature Communications
  8. Germline Stem Cells: The First Guards of Heredity
    Vilma Barroca, Pierre Fouchet · 2008 · Cell stem cell
  9. YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cells
    Deepthy Francis, Bhavna Chanana, Beatriz Fernandez, BENJAMIN LEE GORDON, Tiffany Mak, Isabel M. Palacios · 2019 · PLoS ONE
  10. Reproductive stage- and season-dependent culture characteristics of enriched caprine male germline stem cells
    SHIVA PRATAP SINGH, S.D. Kharche, Manisha Pathak, Yogesh Soni, Ravi Ranjan, M. K. Singh, Manmohan Singh Chauhan · 2022 · Cytotechnology
  11. Extrinsic and Intrinsic Control of Germline Stem Cell Regulation in the Drosophila Ovary
    Nian Zhang, Ting Xie · 2009 · Humana Press eBooks
  12. Adar Regulates Drosophila melanogaster Spermatogenesis via Modulation of BMP Signaling
    Qian Zhang, Xinxin Fan, Fang Fu, Yuedan Zhu, Guan‐Zheng Luo, Haiyang Chen · 2024 · International Journal of Molecular Sciences
  13. Autophagy is dispensable in germline stem cells but is required in the cap cells for their maintenance in the Drosophila ovarian niche
    Kiran Suhas Nilangekar, Bhupendra V. Shravage · 2025 · Stem Cell Reports
  14. Stem Cell Aging
    Primož J. Rožman, Katerina Jazbec, Mojca Jež · 2018 · InTech eBooks
  15. Single‐cell transcriptome characteristics of testicular terminal epithelium lineages during aging in the Drosophila
    Xia Chen, Yujuan Qi, Qiuru Huang, Chi Chin Sun, Yanli Zheng, Ji Li, Yi Y. Shi, Xinmeng Cheng, Zhenbei Li, Sen Zheng et al. · 2023 · Aging Cell
  16. Regulatory Mechanisms of the Germline Stem Cell Niche in Drosophila melanogaster
    Yoshiki Hayashi, Satoru Kobayashi · 2018 · Diversity and commonality in animals
  17. Drosophila SERTAD domain protein Taranis is required in somatic cells for maintenance of male germline stem cells
    Pranabananda Dutta, Soma Nath, Jinghong Li, Willis X. Li · 2020 · Developmental Dynamics
  18. p53, sex, and aging: lessons from the fruit fly
    Jae H. Hur, David W. Walker · 2009 · Aging
  19. Role of biological markers in stem cell aging and its implications in therapeutic processes
    Sivanandane Sittadjody, Aamina Ali, Thilakavathy Thangasamy, M. Akila, Ravindran Kumaran, Emmanuel C. Opara · 2021 · Elsevier eBooks
  20. Stem Cell Niche
    Chenhui Wang, Jun Chen, Pei Wen, Pei Sun, Rongwen Xi · 2016 · Springer eBooks
  21. Makeshift sperm production
    Allan C. Spradling · 2008 · Nature
  22. Germline stem cell isolation, lineage tracing, and aging in a protochordate
    Tom Levy, Chiara Anselmi, Katherine J. Ishizuka, Tal Gordon, Yotam Voskoboynik, Aaron McGeever, Angela M. Detweiler, Liron Levin, Karla J. Palmeri, Daniel Dan Liu et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Age-related decline in niche self-renewal factors drives testis aging via Hairless, Imp, and Chinmo
    Pin-Kuan Chiang, Ya‐Chien Lee, Yu Zheng, Chun-Fang Peng, Yue Wang, Shao-Lun Chang, Hwei‐Jan Hsu, Li‐Sung Hsu, Alessandro A. Bailetti, Erika A Bach et al. · 2026 · Science Advances
  24. The Male Stem Cell Niche: Insights from Drosophila and Mammalian Model Systems
    Fani Papagiannouli, Ingrid Lohmann · 2015 · Stem cell biology and regenerative medicine
  25. Stem Cell Niche
    Chenhui Wang, Pei Wen, Pei Sun, Rongwen Xi · 2013 · Springer eBooks
  26. Testicular Stem Cell Niche
    Devendra Pathak, Kritima Kapoor, Mukesh Kumar Gupta · 2021 · Springer eBooks
  27. Niche-dependent modular regulation of the stem cell transcriptome separates cell identity and potential
    Amelie A. Raz, Hafidh Hassan, Yukiko M Yamashita · 2026 · Proceedings of the National Academy of Sciences
  28. THE JAK/STAT PATHWAY IS REUTILIZED IN DROSOPHILA SPERMATOGENESIS
    Lingfeng Tang · 2014 · UKnowledge (University of Kentucky)
  29. The aging spermatogonial stem cell niche
    Hue M. La, Robin M. Hobbs · 2020 · Advances in stem cells and their niches
  30. Senescence in aging
    Sofie Lautrup, Alexander S. Anisimov, Mariá José Lagartos-Donate, Evandro Fei Fang · 2022 · Elsevier eBooks
  31. Aging of the Niche and the Microenvironment and Its Role in Stem Cell Aging
    Hartmut Geiger · 2012 · Else Kröner-Fresenius Symposia
  32. Irreversible effects of youthful choices in aged adults
    Alana M. O’Reilly · 2019 · PLoS Genetics
  33. Aging of Epidermal Stem Cells
    Alexandra Charruyer, Ruby Ghadially · 2016 · Springer eBooks
  34. Anillin Stabilizes Membrane-cytoskeleton Interactions During Drosophila Male Germ Cell Cytokinesis
    Philip Goldbach · 2011 · Library and Archives Canada (Government of Canada)
  35. Assessing the effectiveness of incentives towards employees' performance in Abaqulusi Local Municipality
    Nokulunga C. Ngwenya · 2019
  36. Modulating DNA Polα Enhances Cell Reprogramming Across Species
    Rajesh Ranjan, Binbin Ma, Ryan J. Gleason, Yijun Liao, Yingshan Bi, Brendon E. M. Davis, Guanghui Yang, Maggie Clark, Vikrant Mahajan, Madison Condon et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  37. Age-related declines in niche self-renewal factors controls testis aging and spermatogonial stem cell competition through Hairless, Imp, and Chinmo
    Yu Zheng, Ya‐Chien Lee, Yuting Wang, Pin-Kuan Chiang, Shao-Lun Chang, Hwei‐Jan Hsu, Li‐Sung Hsu, Erika A Bach, Chen‐Yuan Tseng · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Antagonistic Pleiotropy: The Role of Smurf2 in Cancer and Aging: A Dissertation
    Charusheila Ramkumar · 2012 · eScholarship@UMassChan
  39. Novel Insights into Regulation of Stem Cell Aging by Aging of the Niche and Alterations in Systemic Factors
    Hartmut Geiger · 2010 · Else Kröner-Fresenius Symposia
  40. Identification of microenvironment factors that regulate hematopoietic stem and progenitor cells
    Shannon M. Buckley · 2009 · University of Minnesota Digital Conservancy (University of Minnesota)
  41. Aging of Epidermal Stem Cells
    Alexandra Charruyer, Ruby Ghadially · 2009 · Springer eBooks
  42. Glycosaminoglycan Dependent Isolation of Mesenchymal Chondroprogenitor Populations from Human Bone Marrow
    Janice O’Sullivan · 2013 · ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway)
  43. Analyzing stem cell dynamics: use of cutting edge genetic approaches in model organisms
    Gary R. Hime, Nicole A. Siddall, Katja Horvay, Helen E. Abud · 2015 · Frontiers in Biology
  44. The Stem Cell Niche and Its Role in Self-Renewal, Aging, and Malignancy
    S.J. Peter Breslin, Andrew G. Volk, Jiwang Zhang · 2013 · Wiley-VCH eBooks
  45. Sex-specific effects of drosophila p53 on adult life span
    Jie Shen · 2015 · University of Southern California Digital Library
  46. Age-Related Changes to Drosophila m. Male Germline Stem Cells
    Hila Toledano, D. Leanne Jones · 2015 · Springer eBooks
  47. Deleterious Roles of Inflammatory Adhesion Molecules during Aging
    Yani Zou, Byung Chul Yu, Hae Young Chung · 2010 · Science Publishers eBooks
  48. Investigating the Role of the Histone Demethylase Lid in the Drosophila Testis Niche
    Yuping Derek Li · 2014
  49. Expressão de marcadores moleculares em espermatogônias
    Mariana Ianello Giassetti · 2015
  50. ANALYSIS OF THE ROLES OF HISTONE DEMETHYLASES IN DROSOPHILA MELANOGASTER MALE GERM CELL MAINTENANCE AND DIFFERENTIATION
    Lama Tarayrah · 2014
  51. Jak/Stat Signaling Regulates Gametogenesis and Age-Related Reproductive Maintenance
    Michelle S. Giedt · 2018 · UKnowledge (University of Kentucky)
  52. Contrasting effects of aging on the expression of transposons, the piRNA machinery and mitochondrial transcripts in the Drosophila ovary
    Alexandra A. Erwin, Justin P. Blumenstiel · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  53. THE CHROMATIN FACTOR ENHANCER OF POLYCOMB PROMOTES DIFFERENTIATION OF ADULT GERMLINE STEM CELLS AND CYST STEM CELLS IN THE DROSOPHILA TESTIS
    Lijuan Feng · 2016
  54. ANALYSIS OF TRANSCRIPTIONAL AND EPIGENETIC REGULATION IN DROSOPHILA MELANOGASTER MALE GERM CELLS DIFFERENTIATION
    Cindy Lim · 2013
  55. Stem Cells: Muscle Cells Enwrap Escaped Germline Stem Cells in C. elegans
    Charlotte A. Kelley, Erin J. Cram · 2019 · Current Biology
  56. Therapeutic approaches for the treatment of aging-induced stem cell dysfunction
    Debora Bizzaro, Francesco Paolo Russo, Patrizia Burra · 2021 · Elsevier eBooks
  57. Aging of Epidermal Stem Cells
    Alexandra Charruyer, Ruby Ghadially · 2015 · Springer eBooks
  58. Deciphering the genetic background of quantitative traits using machine learning and bioinformatics frameworks
    Faisal Ramzan · 2021
  59. Loss-of-Function Analysis Elucidates Essential Roles of eIF4E Isoforms in Drosophila Spermatogenesis
    Liang Chen · 2016 · McGill Science Undergraduate Research Journal
  60. The Fifth Annual Symposium of the Midwest Aging Consortium
    Brenda F. Reader, Lorena Rosas, Bailey A. Knopf, Yang Liu, Diego Alzate‐Correa, Ajay Bhat, Anna Carey, Ana María Cuervo, Sanjana Dayal, Rafael Sênos Demarco et al. · 2024 · The Journals of Gerontology Series A
  61. ‘Nomadic’ Hematopoietic Stem Cells Navigate the Embryonic Landscape
    Anand Badhri Narayan, Senthil Kumar Hariom, Ayan Prasad Mukherjee, Deotima Das, Aadhira Nair, Everette Jacob Remington Nelson · 2025 · Stem Cell Reviews and Reports
  62. Divergent functions of the RNA-binding protein, Mei-P26 in germline and somatic lineages of Drosophila testis
    Shallinie Thangadurai, Elena Pak, Alexander K. Murashov · 2026 · Frontiers in Cell and Developmental Biology
  63. Mechanisms of spontaneous loss of heterozygosity in adult stem cells
    Lara Al-Zoubi · 2020 · theses.fr (ABES)
  64. Lin28 Represses Hub Cell microRNAs to Maintain Drosophila Testis Niche Function
    Perinthottathil Sreejith, Changsoo Kim · 2026 · Development & Reproduction
  65. Asymmetric Chromosome Establishment and Segregation During Germline Stem Cell Division
    Yijun Liao, Xin Chen · 2026 · Advances in experimental medicine and biology
  66. Niche cell positioning drives functional heterogeneity in the Drosophila testis stem cell niche
    Jennifer M. Viveiros, Erika L. Matunis · 2026 · Genetics
  67. THE INTERACTIONS BETWEEN JAK/STAT SIGNALING LIGANDS IN DROSOPHILA MELANOGASTER
    Qian Chen · 2014 · UKnowledge (University of Kentucky)
  68. Stem Cells and Stem Cell Niches in Tissue Homeostasis: Lessons from the Expanding Stem Cell Populations of Drosophila
    Yukiko M Yamashita · 2009 · Humana Press eBooks