The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration
Open accessAbstract
SUMMARY Prostate cancer (PCa) is heterogeneous and contains both differentiated and undifferentiated tumor cells, but the relative functional contribution of these two cell populations remains unclear. Here we report distinct molecular, cellular, and tumor-propagating properties of PCa cells that express high (PSA+) and low (PSA−/lo) levels of the differentiation marker PSA. PSA−/lo PCa cells are quiescent and refractory to stresses including androgen deprivation, exhibit high clonogenic potential, and possess long-term tumor-propagating capacity. They preferentially express stem cell genes and can undergo asymmetric cell division generating PSA+ cells. Importantly, PSA−/lo PCa cells can initiate robust tumor development and resist androgen ablation in castrated hosts, and harbor highly tumorigenic castration-resistant PCa cells that can be prospectively enriched using ALDH+CD44+α2β1+ phenotype. In contrast, PSA+ PCa cells possess more limited tumor-propagating capacity, undergo symmetric division and are sensitive to castration. Together, our study suggests PSA−/lo cells may represent a critical source of castration-resistant PCa cells.
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Cites
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Self-citationMechanisms of Asymmetric Stem Cell Division
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Self-citationAndrogen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer
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Cited by
Cellular plasticity and the neuroendocrine phenotype in prostate cancer
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The role of microRNAs in the regulation of cancer stem cells
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Metadata
- Authors
- Qin, J., Liu, X., Laffin, B., Chen, X., Choy, G., Jeter, C. R., Calhoun-Davis, T., Li, H., Palapattu, G. S., Pang, S., Lin, K., Huang, J., Ivanov, I., Li, W., Suraneni, M. V., & Tang, D. G.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 10
- Issue
- 5
- Pages
- 556-569
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2066235353
- Cited by
- 317
- References
- 40
- FWCI
- 25.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Qin, J., Liu, X., Laffin, B., Chen, X., Choy, G., Jeter, C. R., Calhoun-Davis, T., Li, H., Palapattu, G. S., Pang, S., Lin, K., Huang, J., Ivanov, I., Li, W., Suraneni, M. V., & Tang, D. G. (2012). The PSA−/lo Prostate Cancer Cell Population Harbors Self-Renewing Long-Term Tumor-Propagating Cells that Resist Castration. Cell Stem Cell. https://doi.org/10.1016/j.stem.2012.03.009
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