Modeling a Genetic Risk for Schizophrenia in iPSCs and Mice Reveals Neural Stem Cell Deficits Associated with Adherens Junctions and Polarity

Yoon, Ki-Jun, Nguyen, Ha Nam, Ursini, Gianluca, Zhang, Fengyu, Kim, Nam-Shik, Wen, Zhexing, Makri, Georgia, Nauen, David +18 more·2014·Cell Stem Cell

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    Julien George Roth, Kristin L. Muench, Aditya Asokan, Victoria M Mallett, Hui Gai, Yogendra Verma, Stephen G. Weber, Carol A. Charlton, Jonas L. Fowler, Kyle M. Loh et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Control of microglial dynamics by the Arp2/3 complex and the autism- and schizophrenia-associated protein CYFIP1
    Scott-Solache, James, Pei, Jiaxin, Drew, James, López-Doménech, Guillermo, Jolivet, Renaud B., Nieto-Rostro, Manuela, Davenport, Elizabeth C., Arancibia-Cárcamo, I. Lorena, Attwell, David, Kittler, Josef T. · 2026 · Proceedings of the National Academy of Sciences
  4. Neural tissue microphysiological systems in the era of patient-derived pluripotent stem cells
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  5. Familial 15q11.2 Micro deletions are not Fully Penetrant in Two Cases with Hereditary Spastic Paraplegia and Dysmorphic Features
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  6. Functional Comparison of Blood-Derived Human Neural Progenitor Cells
    Eszter Szabó, Flóra Juhász, Edit Hathy, Dóra Reé, László Homolya, Zsuzsa Erdei, János Réthelyi, Ágota Apáti · 2020 · International Journal of Molecular Sciences
  7. Cell group analysis reveals changes in upper-layer neurons associated with schizophrenia
    Rujia Dai, Lulu Chen, Sihan Liu, Chiung-Ting Wu, Yu Chen, Yi Wei Jiang, Rujia Dai, Qihang Wang, Richard F. Kopp, Guoqiang Yu et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Cell mediated gene therapy: A guide for doctors in the clinic
    Moon Jong Noh · 2015 · World Journal of Medical Genetics
  9. Modeling Schizophrenia with Human Stem Cells
    Juliana Minardi Nascimento, Verônica Monteiro Saia-Cereda, Giuliana S. Zuccoli, Danielle Gouvêa Junqueira, Daniel Martins‐de‐Souza · 2018 · Springer eBooks
  10. Sex-based Dysregulation of Inflammation-related Genes in Periodontitis.
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  11. Cerebral organoid research for pediatric patients with neurological disorders
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  12. Human-Induced Pluripotent Stem Cells: Banking and Characterization
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  13. Induced pluripotent stem cells as models of human neurodevelopmental disorders
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  14. Meta-analysis of transcriptional regulatory networks for lipid metabolism in neural cells from schizophrenia patients based on an open-source intelligence approach
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  15. Pharmacogenetics of antipsychotic drug response
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  16. From Human Pluripotent Stem Cells to Neurons: Promises and Pitfalls
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  17. Schizophrenia: Risky neurodevelopment
    Fiona B. Carr · 2014 · Nature Medicine
  18. hiPSC Models Relevant to Schizophrenia
    B. Hartley, Y. Hadas, K. Brennand · 2016 · Handbook of behavioral neuroscience
  19. Schizophrenia hiPSC neurons display expression changes that are enriched for disease risk variants and a blunted activity-dependent response
    Panos Roussos, Boris Guennewig, Dominik C. Kaczorowski, Guy Barry, Kristen Brennand · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
  20. What if it was easier to prevent schizophrenia than to treat it?
    Kristen Brennand · 2017 · Schizophrenia
  21. Modeling Psychiatric Disorders Using Patient-derived Induced Pluripotent Stem Cells
    Ha Nam Nguyen · 2015
  22. Genetic Epilepsy Modeling With Human Pluripotent Stem Cells
    Louis T. Dang, Jack M. Parent · 2017 · Elsevier eBooks
  23. Induced pluripotent stem cells for modeling schizophrenia pathogenesis
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  24. Adherens junctions and cell polarity: What they are and how they relate to congenital Zika virus syndrome
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  25. iPSC-based modeling in psychiatric disorders
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  26. 2 Human-Induced Pluripotent Stem Cells: Banking and Characterization
    Uthra Rajamani, Lindsay Lenaeus, Loren Ornelas, Dhruv Sareen · 2017 · CRC Press eBooks
  27. Faculty Opinions recommendation of Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure.
    Alysson Renato Muotri · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  28. Application of Stem Cells to Understanding Psychiatric Disorders
    Kristen Brennand · 2017 · Oxford University Press eBooks
  29. Metabolic stress and antipsychotic treatment induced gene expression alterations in human cell
    Sára Kálmán · 2016
  30. Neurodevelopmental Mechanisms for Psychotic Disorders
    Nao J. Gamo, Takeshi Sakurai, Hanna Jaaro-Peled, Akira Sawa · 2017 · Oxford University Press eBooks
  31. Animal and Cellular Models of Psychotic Disorders
    Mikhail V. Pletnikov, Guo‐li Ming, Christopher A. Ross · 2017
  32. Faculty Opinions recommendation of Cerebral organoids reveal early cortical maldevelopment in schizophrenia-computational anatomy and genomics, role of FGFR1.
    Alysson Renato Muotri · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  33. Loss of function in the autism and schizophrenia-associated gene CYFIP1 in human microglia supports a role in synaptic pruning
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  34. Application of Stem Cells to Understanding Psychiatric Disorders
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  35. Modeling treatment-resistant depression in the preclinical setting
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  36. Additional file 7 of Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes
    Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Júlia Koller, László Nagy et al. · 2020 · Figshare
  37. Additional file 6 of Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes
    Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Koller, Júlia, László Nagy et al. · 2020 · Figshare
  38. Additional file 8 of Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes
    Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Koller, Júlia, László Nagy et al. · 2020 · Figshare
  39. Additional file 9 of Investigation of de novo mutations in a schizophrenia case-parent trio by induced pluripotent stem cell-based in vitro disease modeling: convergence of schizophrenia- and autism-related cellular phenotypes
    Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Koller, Júlia, László Nagy et al. · 2020 · Figshare
  40. Additional file 1 of Application of Airy beam light sheet microscopy to examine early neurodevelopmental structures in 3D hiPSC-derived human cortical spheroids
    Dwaipayan Adhya, George Chennell, James A Crowe, Eva P. Valencia-Alarcón, James Seyforth, Neveen A. Hosny, Marina V. Yasvoina, Forster, Robert, Simon Baron‐Cohen, Anthony Christopher Vernon et al. · 2021 · Figshare