Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs

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Items 101–200 of 339

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7. Functional screening of guide RNAs targeting the regulatory and structural HIV-1 viral genome for a cure of AIDS
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8. CRISPR Gene Editing in the Kidney
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9. Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation
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10. Genome editing in cardiovascular diseases
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11. Application of CRISPR/Cas9 genome editing to the study and treatment of disease
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12. CRISPR-Cas9-Based Knockout of the Prion Protein and Its Effect on the Proteome
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13. The genome editing revolution: A CRISPR‐Cas TALE off‐target story
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14. Brain Organoids as Tools for Modeling Human Neurodevelopmental Disorders
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15. Targeting specificity of APOBEC-based cytosine base editor in human iPSCs determined by whole genome sequencing
    Erica L. McGrath, Hyunsu Shin, Linyi Zhang, Je‐Nie Phue, Wells W. Wu, Rong‐Fong Shen, Yoon-Young Jang, Javier R. Revollo, Zhaohui Ye · 2019 · Nature Communications
16. Gene-knocked out chimeric antigen receptor (CAR) T cells: Tuning up for the next generation cancer immunotherapy
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17. The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches
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18. Human germline genome editing
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19. The iCRISPR Platform for Rapid Genome Editing in Human Pluripotent Stem Cells
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20. CRISPR/Cas9 system: a reliable and facile genome editing tool in modern biology
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21. Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases
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22. The application of genome editing in studying hearing loss
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23. CRISPR/Cas9, a powerful tool to target human herpesviruses
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24. Precision gene editing technology and applications in nephrology
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25. CCR5 editing by Staphylococcus aureus Cas9 in human primary CD4+ T cells and hematopoietic stem/progenitor cells promotes HIV-1 resistance and CD4+ T cell enrichment in humanized mice
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26. Light-Activated Nuclear Translocation of Adeno-Associated Virus Nanoparticles Using Phytochrome B for Enhanced, Tunable, and Spatially Programmable Gene Delivery
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27. The Hope and Hype of CRISPR-Cas9 Genome Editing
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28. Synthesis of an arrayed sgRNA library targeting the human genome
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29. The comparison of ZFNs, TALENs, and SpCas9 by GUIDE-seq in HPV-targeted gene therapy
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30. Anticipating and Identifying Collateral Damage in Genome Editing
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31. Effects of CRISPR/Cas9 dosage on TICAM1 and RBL gene mutation rate, embryonic development, hatchability and fry survival in channel catfish
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32. Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
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33. CRISPR is knocking on barn door
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34. Genome editing strategies: potential tools for eradicating HIV-1/AIDS
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35. Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease
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36. Gene correction in patient-specific iPSCs for therapy development and disease modeling
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37. Using the GEMM-ESC strategy to study gene function in mouse models
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38. CRISPR/Cas9 System: A Bacterial Tailor for Genomic Engineering
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39. CRISPR-cas gene-editing as plausible treatment of neuromuscular and nucleotide-repeat-expansion diseases: A systematic review
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40. Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders
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41. Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair
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42. Dopaminergic precursors differentiated from human blood-derived induced neural stem cells improve symptoms of a mouse Parkinson's disease model
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43. Variability in Genome Editing Outcomes: Challenges for Research Reproducibility and Clinical Safety
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44. CRISPR Gene Editing of Human Primary NK and T Cells for Cancer Immunotherapy
    Ezgi Elmas, Noushin Saljoughian, Marcelo de Souza Fernandes Pereira, Brian P. Tullius, Kinnari Sorathia, Robin J. Nakkula, Dean Anthony Lee, Meisam Naeimi Kararoudi · 2022 · Frontiers in Oncology
45. Technologies and Computational Analysis Strategies for CRISPR Applications
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46. Recent progress of iPSC technology in cardiac diseases
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47. GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos
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48. Human iPSCs and Genome Editing Technologies for Precision Cardiovascular Tissue Engineering
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49. Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases
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50. Novel Genome-Editing Tools to Model and Correct Primary Immunodeficiencies
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51. The CRISPR/Cas9 system efficiently reverts the tumorigenic ability of BCR/ABL in vitro and in a xenograft model of chronic myeloid leukemia
    Ignacio García‐Tuñón, María Hernández‐Sánchez, José Luis Ordóñez, Verónica Alonso-Pérez, Miguel Quijada‐Álamo, Rocí­o Benito, Carmen Guerrero, Jesús María Hernández‐Rivas, Manuel Sánchez‐Martín · 2017 · Oncotarget
52. Therapeutic gene editing in haematological disorders with CRISPR /Cas9
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53. Overview of guide RNA design tools for CRISPR-Cas9 genome editing technology
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54. Novel HDAd/EBV Reprogramming Vector and Highly Efficient Ad/CRISPR-Cas Sickle Cell Disease Gene Correction
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55. Modeling genetic epilepsies in a dish
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56. Genome Editing
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57. Exome sequencing in the knockin mice generated using the CRISPR/Cas system
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58. CRISPR/Cas9 Technology: Applications and Human Disease Modeling
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59. CRISPR/Cas-Mediated Site-Specific Mutagenesis in Arabidopsis thaliana Using Cas9 Nucleases and Paired Nickases
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60. Genome-edited human pluripotent stem cell–derived macrophages as a model of reverse cholesterol transport—brief report
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61. Functional interrogation of Lynch syndrome‐associated MSH2 missense variants via CRISPR‐Cas9 gene editing in human embryonic stem cells
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62. Inherited cardiac diseases, pluripotent stem cells, and genome editing combined—the past, present, and future
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63. Trio deep-sequencing does not reveal unexpected off-target and on-target mutations in Cas9-edited rhesus monkeys
    Xin Luo, Yaoxi He, Chao Zhang, Xiechao He, Lanzhen Yan, Min Li, Ting Hu, Yan Hu, Jin Jiang, Xiaoyu Meng et al. · 2019 · Nature Communications
64. Human Inducible Pluripotent Stem Cells and Autism Spectrum Disorder: Emerging Technologies
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65. Non-SMC Element 2 (NSMCE2) of the SMC5/6 Complex Helps to Resolve Topological Stress
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66. CRISPR Genome Engineering for Human Pluripotent Stem Cell Research
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67. Factors Impacting Efficacy of AAV-Mediated CRISPR-Based Genome Editing for Treatment of Choroidal Neovascularization
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68. CRISPR ‐Cas9 technology and its application in haematological disorders
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69. TALEN-mediated genome engineering to generate targeted mice
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70. Trio-Based Deep Sequencing Reveals a Low Incidence of Off-Target Mutations in the Offspring of Genetically Edited Goats
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71. Modeling developmental neuropsychiatric disorders with iPSC technology: challenges and opportunities
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72. CRISPR/Cas9-Mediated Knockout and In Situ Inversion of the ORF57 Gene from All Copies of the Kaposi's Sarcoma-Associated Herpesvirus Genome in BCBL-1 Cells
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73. Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers
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74. Utilizing microphysiological systems and induced pluripotent stem cells for disease modeling: a case study for blood brain barrier research in a pharmaceutical setting
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75. PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons
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76. Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”
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77. Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in β-Thalassemia Induced Pluripotent Stem Cells (iPSCs)
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78. Experimental Models to Study Autism Spectrum Disorders: hiPSCs, Rodents and Zebrafish
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79. The Off-Targets of Clustered Regularly Interspaced Short Palindromic Repeats Gene Editing
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80. The Rise of CRISPR/Cas for Genome Editing in Stem Cells
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81. A Rapid Pipeline to Model Rare Neurodevelopmental Disorders with Simultaneous CRISPR/Cas9 Gene Editing
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82. hiPSCs in cardio-oncology: deciphering the genomics
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83. CRISPR Craze to Transform Cardiac Biology
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84. Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases
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85. Beyond traditional pharmacology: new tools and approaches
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86. Dissecting diabetes/metabolic disease mechanisms using pluripotent stem cells and genome editing tools
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87. Optogenetic Modulation of Intracellular Signalling and Transcription: Focus on Neuronal Plasticity
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88. Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”
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89. Assessment of genomic changes in a CRISPR/Cas9 Phaeodactylum tricornutum mutant through whole genome resequencing
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90. Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones
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91. Generation of Naivetropic Induced Pluripotent Stem Cells from Parkinson's Disease Patients for High-Efficiency Genetic Manipulation and Disease Modeling
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92. Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein
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93. Comprehensive off-target analysis of dCas9-SAM-mediated HIV reactivation via long noncoding RNA and mRNA profiling
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94. Delivery methods for site-specific nucleases: Achieving the full potential of therapeutic gene editing
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95. CRISPR/Cas9-Mediated Genome Editing for Huntington’s Disease
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96. A pre-screening FISH-based method to detect CRISPR/Cas9 off-targets in mouse embryonic stem cells
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97. Roles of lncRNAs in the transcription regulation of HIV-1
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98. Utilization of TALEN and CRISPR/Cas9 technologies for gene targeting and modification
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99. What’s Changed with Genome Editing?
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100. Progress and Prospects of Gene Editing in Pluripotent Stem Cells
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