Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes
Tarlow, Branden D., Pelz, Carl, Naugler, Willscott E., Wakefield, Leslie, Wilson, Elizabeth M., Finegold, Milton J., Grompe, Markus·2014·Cell Stem Cell
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- Emerging signals regulating liver tumor initiating cellsJingyu Chen, Chien-Yu Chen, Christopher C. Nguyen, Lulu Chen, Kangmin Lee, Bangyan L. Stiles · 2018 · Liver Research
- Hepatic regeneration in aging: Cell type plasticity and redundanciesCatherine Li, Timothy J. Chalmers, Ashley S.A. Wong, Moran Zhou, Maria B. Marinova, Michael J. Bertoldo, Lindsay E. Wu · 2020 · Advances in stem cells and their niches
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- Liver DevelopmentMatthew C. Gillen, Stacey S. Huppert · 2021 · Cambridge University Press eBooks
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- Liver Stem Cell NicheTohru Itoh · 2015 · Stem cell biology and regenerative medicine
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- Hepatic Progenitor Cell TransplantationDavid A. Shafritz · 2015 · Elsevier eBooks
- Cell Therapy in Liver DiseasesAnupam Kumar · 2017 · Springer eBooks
- Hepatocyte to Biliary TransdifferentiationVishakha Bhave · 2015 · Elsevier eBooks
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- Highlight report: liver regeneration by a subset of hepatocytes with high expression of telomerasePatrick Nell · 2019 · Archives of Toxicology
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- Studies on Differentiation Mechanisms of Epithelial Cells in the Digestive System昌一 杉山, Masakazu Sugiyama · 2018 · Institutional Repositories DataBase (IRDB)
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- Faculty Opinions recommendation of Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration.Malcolm Ronald Alison · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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