The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer
Open accessAbstract
SUMMARY Emerging evidence suggests that microRNAs can initiate asymmetric division, but whether microRNA and protein cell fate determinants coordinate with each other remains unclear. Here we show that miR-34a directly suppresses Numb in early-stage colon cancer stem cells (CCSCs), forming an incoherent feedforward loop (IFFL) targeting Notch to separate stem and non-stem cell fates robustly. Perturbation of the IFFL leads to a new intermediate cell population with plastic and ambiguous identity. Lgr5+ mouse intestinal/colon stem cells (ISCs) predominantly undergo symmetric division, but turn on asymmetric division to curb the number of ISCs when proinflammatory response causes excessive proliferation. Deletion of miR-34a inhibits asymmetric division and exacerbates Lgr5+ ISC proliferation under such stress. Collectively, our data indicate that microRNA and protein cell fate determinants coordinate to enhance robustness of cell fate decision, and they provide a safeguard mechanism against stem cell proliferation induced by inflammation or oncogenic mutation.
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Cites
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
A microRNA component of the p53 tumour suppressor network
He, L., He, X., Lim, L. P., de Stanchina, E., Xuan, Z., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., et al. (2007) · Nature · doi:10.1038/nature05939 · Cited by 2,692
MicroRNA-34a regulates cardiac ageing and function.
Boon, R. A., Iekushi, K., Lechner, S., Seeger, T., Fischer, A., Heydt, S., Kaluza, D., Tréguer, K., Carmona, G., Bonauer, A., et al. (2013) · Nature · doi:10.1038/nature11919 · Cited by 821
Asymmetric cell divisions promote Notch-dependent epidermal differentiation
Williams, S. E., Beronja, S., Pasolli, H. A., & Fuchs, E. (2011) · Nature · doi:10.1038/nature09793 · Cited by 406
Controlled gene expression in primary Lgr5 organoid cultures
Koo, B.-K., Stange, D. E., Sato, T., Karthaus, W., Farin, H. F., Huch, M., van Es, J. H., & Clevers, H. (2012) · Nature Methods · doi:10.1038/nmeth.1802 · Cited by 320
Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments Is Lost in Precancerous Tissue
Quyn, A. J., Appleton, P. L., Carey, F. A., Steele, R. J. C., Barker, N., Clevers, H., Ridgway, R. A., Sansom, O. J., & Näthke, I. S. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2009.12.007 · Cited by 242 · cited 2×
“Previously, ISCswere thought to undergo asymmetric division exclusively to protect their number and genomic integrity (Goulas et al., 2012; Potten et al., 2002; Quyn et al., 2010).”
BackgroundIntact p53-Dependent Responses in miR-34–Deficient Mice
Concepcion, C. P., Han, Y.-C., Mu, P., Bonetti, C., Yao, E., D'Andrea, A., Vidigal, J. A., Maughan, W. P., Ogrodowski, P., & Ventura, A. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002797 · Cited by 197
Cited by
Notch signaling pathway: architecture, disease, and therapeutics
Zhou, B., Lin, W., Long, Y., Yang, Y., Zhang, H., Wu, K., & Chu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00934-y · Cited by 1,114
Yan, H., & Bu, P. (2021) · Essays in Biochemistry · doi:10.1042/ebc20200032 · Cited by 667
Self-citationMicroRNAs in the etiology of colorectal cancer: Pathways and clinical implications
Strubberg, A. M., & Madison, B. B. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.027441 · Cited by 147
Metadata
- Authors
- Bu, P., Wang, L., Chen, K.-Y., Srinivasan, T., Murthy, P. K. L., Tung, K.-L., Varanko, A. K., Chen, H. J., Ai, Y., King, S., Lipkin, S. M., & Shen, X.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 18
- Issue
- 2
- Pages
- 189-202
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2273006669
- Cited by
- 158
- References
- 7
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. https://app.cochat.ai/papers/10.1016/j.stem.2016.01.006
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- Bu, P., Wang, L., Chen, K.-Y., Srinivasan, T., Murthy, P. K. L., Tung, K.-L., Varanko, A. K., Chen, H. J., Ai, Y., King, S., Lipkin, S. M., & Shen, X. (2016). A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. Cell Stem Cell. https://doi.org/10.1016/j.stem.2016.01.006
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