PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation

Cruz-Molina, Sara, Respuela, Patricia, Tebartz, Christina, Kolovos, Petros, Nikolic, Milos, Fueyo, Raquel, van Ijcken, Wilfred F.J., Grosveld, Frank +3 more·2017·Cell Stem Cell
DOI 10.1016/j.stem.2017.02.004

Cited by (243)

Items 201–243 of 243

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  2. Ultra-long-range Polycomb-coupled interactions underlie subtype identity of human cortical neurons
    Ilya A Pletenev, Nikita Vaulin, Maria N. Molodova, Ekaterina Kuznechenkova, Anastasia Soldatenkova, Olga Efimova, Anna V. Tvorogova, Philipp Khaitovich, Sergey V. Razin, Sergey V. Ulianov et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  3. Multi-omics profiling reveals MAGEL2-driven defects in human corticogenesis shared across Prader-Willi and Schaaf-Yang syndromes
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  4. Polycomb repressive complex 1 defines the nucleosome landscape but not accessibility at target genes
    Hamish W. King, Robert J. Klose · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  5. Organizing Principles for the Spatial Folding of Chromosomes
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  7. Analysis of Polycomb Repressive Complexes binding dynamics during limb development reveals the prevalence of PRC2-independent PRC1 occupancy
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  8. Faculty Opinions recommendation of Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development.
    Vijay Kumar Tiwari, Arun Mariappan · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  9. Genome-wide profiling reveals a dual role for histone H2A monoubiquitylation at Polycomb-repressed and enhancer chromatin
    Kailynn MacGillivray, Daniel D. Fusca, Luomeng Tan, Reta Aram, Arneet L. Saltzman · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Rewiring of the epigenome and chromatin architecture by retinoic acid signaling during zebrafish embryonic development
    Marta Moreno-Oñate, Lourdes Gallardo-Fuentes, Pedro Manuel Martínez‐García, Silvia Naranjo, Sandra Jiménez-Gancedo, José Luis Gómez-Skármeta, Juan J. Tena, José M. Santos-Pereira · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Transcription factors overcome the repressive impact of Polycomb-associated methylation in tumors
    Min-Kyeong Kwon, Goeun Park, Dayoung Go, Donghyun Park, Sridhar S. Hannenhalli, Sun Shim Choi · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Non-canonical enhancers control gene expression and cell fate in human pluripotent stem cells
    Yang Cao, Oleksandr Dovgusha, A. Ebrahimi, Stephen Bevan, L. Widmer, Fereshteh Torabi, Julia Kurlovich, Ignacio Rodríguez-Polo, Soumen Khan, Manthan Patel et al. · 2025 · bioRxiv
  13. MLL2 facilitates long-range gene regulation through LINE1 elements
    Lara Zorro Shahidian, Lucio Di Filippo, Sarah Malika Robert, Álvaro Rada-Iglesias · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Specialised super-enhancer networks in stem cells and neurons
    Izabela Harabula, Liam Speakman, Francesco Musella, Luca Fiorillo, Luna Zea-Redondo, Alexander Kukalev, Robert A. Beagrie, Kelly J Morris, Lucas Fernandes, Ibai Irastorza-Azcárate et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  15. The exit from naive pluripotency: a platform for the study of enhancer mechanistics
    Mattias Enar Jonasson, Christa Buecker · 2025 · Biochemical Society Transactions
  16. Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency
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  17. N 6 -Methyladenosine Safeguards Mouse and Human Germline Competence
    Ru-Juan Zuo, Baoyan Bai, Kang-Xuan Jin, Mirra Louise Cicilie Søegaard, Erkut Ilaslan, Ying Yao, Jingwei Li, Łukasz Wyrożemski, Yanjiao Li, Xuechen Wu et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  18. Repurposed macroH2A Chromatin Landscapes Guide Cellular Reprogramming
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  19. Additional file 7 of Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
    Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Melidis, Larry, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill et al. · 2024 · Figshare
  20. Additional file 1 of Mechanisms of enhancer action: the known and the unknown
    Panigrahi, Anil, Bert W. O’Malley · 2021 · Figshare
  21. Additional file 1 of β-actin mediated H3K27ac changes demonstrate the link between compartment switching and enhancer-dependent transcriptional regulation
    Syed Raza Mahmood, Said, Nadine Hosny El, Kristin C. Gunsalus, Piergiorgio Percipalle · 2024 · Figshare
  22. Additional file 1 of Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
    Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Melidis, Larry, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill et al. · 2024 · Figshare
  23. Additional file 3 of Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
    Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Melidis, Larry, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill et al. · 2024 · Figshare
  24. Additional file 2 of β-actin mediated H3K27ac changes demonstrate the link between compartment switching and enhancer-dependent transcriptional regulation
    Syed Raza Mahmood, Said, Nadine Hosny El, Kristin C. Gunsalus, Piergiorgio Percipalle · 2024 · Figshare
  25. Additional file 3 of β-actin mediated H3K27ac changes demonstrate the link between compartment switching and enhancer-dependent transcriptional regulation
    Syed Raza Mahmood, Said, Nadine Hosny El, Kristin C. Gunsalus, Piergiorgio Percipalle · 2024 · Figshare
  26. Additional file 2 of Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
    Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Melidis, Larry, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill et al. · 2024 · Figshare
  27. Additional file 6 of Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
    Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Melidis, Larry, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill et al. · 2024 · Figshare
  28. Additional file 5 of Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
    Sean M. Flynn, Somdutta Dhir, Krzysztof Herka, Colm Doyle, Melidis, Larry, Angela Simeone, Winnie W. I. Hui, Rafael de Cesaris Araujo Tavares, Stefan Schoenfelder, David Tannahill et al. · 2024 · Figshare
  29. Additional file 4 of Improved simultaneous mapping of epigenetic features and 3D chromatin structure via ViCAR
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  30. Chromatin priming and co-factor availability shape lineage response to the neuronal pioneer factor ASCL1 in pluripotency
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  31. Mitotic Bookmarking and Chromosomal Coating by Nuclear Receptors: Segregating Myth & Reality
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  32. Identification and characterization of Polycomb repressed gene-enhancer loops
    Charbel Souaid · 2019 · theses.fr (ABES)
  33. Dynamics of the PRC1 complex during normal development and cancer in Drosophila melanogaster
    Vincent Loubière · 2018
  34. Study of Polycomb target genes architecture in Drosophila using multiplexed optical microscopy
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  35. Importance of PRE interactions for the regulation of polycomb domains in Drosophila melanogaster development
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  37. Dual role of ZIC2 during neural induction: from priming transcription factor to enhancer activator
    María Mariner-Faulí, Víctor Sánchez-Gaya, Sarah Malika Robert, Patricia Respuela, Sara Cruz-Molina, Sara Lobato-Moreno, Matteo Trovato, Karin D. Prummel, Kyung‐Min Noh, Judith B. Zaugg et al. · 2026 · Nucleic Acids Research
  38. Polycomb chromatin topology enables long-range enhancer recruitment during craniofacial development
    Yousra Ben Zouari, Onkar Joshi, Adwait Salvi, Sandra Kessler, Sébastien Ducret, Fiona Ross, Sjoerd J.B. Holwerda, Nathalie Vilain, Soujanya Mamilla-Sanivaram, Sebastien Smallwood et al. · 2026 · Nature Communications
  39. Convergent evolution of cluster-wide Hox gene regulation in Bilateria
    Billie E. Davies, Francisco M. Martín-Zamora, Tom Frankish, Elise Parey, Nancy Ellis, Noura Maziak, Kero Guynes, Grygoriy Zolotarov, Yi‐Jyun Luo, Ferdinand Marlétaz et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Enhancers integrate microenvironmental signals in muscle stem cells during regeneration in health, disease, and aging
    Sarah Hachmer, Francis Jeffrey Dilworth · 2026 · Skeletal Muscle
  41. Mechanisms and functional implications of long-range enhancer-dependent gene regulation
    Marianna Iliadou, Endika Haro, Álvaro Rada-Iglesias · 2026 · Nature Genetics
  42. Dynamic TET1 repression coordinates activation of macroH2A.2-poised bivalent genes during neuroectoderm differentiation
    Brendan Terry, Carine Stapel, Fátima Santos, Joshua Kent, Kamal Kishore, Clive S. D’Santos, Ian Chambers, Aled Parry, Wolf Reik · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  43. HDAC7 induction combined with standard-of-care chemotherapy provides a therapeutic advantage in t(4;11) infant B-ALL (Dataset)
    Oriol de Barrios, Juan Ramón Tejedor, Maribel Parra · 2024 · Zenodo (CERN European Organization for Nuclear Research)