PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy

Hsu, Joanne I., Dayaram, Tajhal, Tovy, Ayala, De Braekeleer, Etienne, Jeong, Mira, Wang, Feng, Zhang, Jianhua, Heffernan, Timothy P. +12 more·2018·Cell stem cell

DOI 10.1016/j.stem.2018.10.004

Cited by (426)

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Marinos Kallikourdis, Jesse D. Cochran, Kenneth X. Walsh, Gianluigi Condorelli · 2025 · Circulation Research
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Huiyuan Gong, Fei Liu, Xiaoyu Liu, Shengping Min, Nan Wu, Yueguang Liu, Yueguang Liu, Yuefang Zhang, Yijie Zhang, Yuefang Zhang et al. · 2019 · EBioMedicine
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