A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth
Open accessAbstract
Hair growth can be induced from resting mouse hair follicles by topical application of JAK inhibitors, suggesting that JAK-STAT signaling is required for maintaining hair follicle stem cells (HFSCs) in a quiescent state. Here, we show that Oncostatin M (OSM), an IL-6 family cytokine, negatively regulates hair growth by signaling through JAK-STAT5 to maintain HFSC quiescence. Genetic deletion of the OSM receptor or STAT5 can induce premature HFSC activation, suggesting that the resting telogen stage is actively maintained by the hair follicle niche. Single-cell RNA sequencing revealed that the OSM source is not intrinsic to the hair follicle itself and is instead a subset of TREM2 + macrophages that is enriched within the resting follicle and deceases immediately prior to HFSC activation. In vivo inhibition of macrophage function was sufficient to induce HFSC proliferation and hair cycle induction. Together these results clarify how JAK-STAT signaling actively inhibits hair growth.
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The LAM phenotype is not unique to the fibrotic liver, also being identified in other tissues in the context of sterile injury as well as in macrophages surrounding the bile duct in the healthy liver.
“Interestingly, this phenotype is not unique to the fibrotic liver, also being identified in other tissues in the context of sterile injury (32, 33, 38, 110–121) as well as in macrophages surrounding the bile duct in the healthy liver (62).”
From Targeting macrophages in liver fibrosis (2026) · cites this paper as [113]
In skin, TREM2+ dermal macrophages secrete oncostatin M, which inhibits hair growth by maintaining hair follicle stem cells quiescent.
“In the skin, TREM2+ dermal macrophages secrete oncostatin M, which inhibits hair growth by maintaining hair follicle stem cells in a quiescent state (Wang et al., 2019).”
From TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy (2020) · cites this paper as Wang et al., 2019
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References 55 · Cited by 182
- Authors
- Wang, E. C. E., Dai, Z., Ferrante, A. W., Drake, C. G., & Christiano, A. M.
- Affiliations
- National Skin Centre (SG)
- Columbia University (US)
- Herbert Irving Comprehensive Cancer Center (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Christiano, Angela M.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 24
- Issue
- 4
- Pages
- 654-669.e6
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W2926178617
- Cited by
- 182
- References
- 55
- Citations by year
- 2026: 14 · 2025: 34 · 2024: 26 · 2023: 28 · 2022: 20 · 2021: 27 · 2020: 25 · 2019: 8
- FWCI
- 27.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (S10OD020056)
- National Research Council
- Center for Outcomes Research and Evaluation, Yale School of Medicine
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- TREM2+ macrophages, dermal macrophages, oncostatin M, hair follicle stem cells, stem cell quiescence, hair growth inhibition, JAK/STAT signaling, STAT5, IL-6 family cytokines, telogen, macrophage depletion, hair cycle
- MeSH terms
- Animals, Cell Cycle, Female, Hair, Humans, Macrophages, Male, Membrane Glycoproteins, Mice, Inbred C57BL, Mice, Transgenic, Receptors, Immunologic, Stem Cells, Signal Transduction, Hair Follicle, Dermis, Cell Proliferation, STAT5 Transcription Factor, Mice, Janus Kinase 2, Oncostatin M
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