OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome

Xu, Ranjie, Brawner, Andrew T., Li, Shenglan, Liu, Jing-Jing, Kim, Hyosung, Xue, Haipeng, Pang, Zhiping P., Kim, Woo-Yang +3 more·2019·Cell Stem Cell
DOI 10.1016/j.stem.2019.04.014

Cited by (193)

Items 101–193 of 193

  1. A Cerebral Organoid Connectivity Apparatus to Model Neuronal Tract Circuitry
    Denise A. Robles, Andrew J. Boreland, Zhiping P. Pang, Jeffrey D. Zahn · 2021 · Micromachines
  2. Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model
    Rui Dang, Mridul Dalmia, Ziyuan Ma, Mengmeng Jin, Kushal Aluru, Vincent R. Mirabella, Ava V. Papetti, Li Cai, Peng Jiang · 2025 · Cell Regeneration
  3. Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer's Disease
    Mengmeng Jin, Ranjie Xu, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Le Wang, Alessandra Cadete Martini, Matteo Bernabucci, Ping Xie, Kelvin Y. Kwan et al. · 2021 · SSRN Electronic Journal
  4. Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome
    Bianca Rusu, Bharti Kukreja, Taiyi Wu, Sophie J. Dan, Min-Yi Feng, B. Kalish · 2023 · eNeuro
  5. Human-mouse chimeric brain models constructed from iPSC-derived brain cells: Applications and challenges
    Ya Zhao, Peng Liu, Yinghua Wang, Yifan Ma, Wenwen Guo, Changhong Shi · 2024 · Experimental Neurology
  6. Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omics
    Hui‐Qi Qu, Yichuan Liu, John J. Connolly, Frank D. Mentch, Charlly Kao, Hakon H. Hakonarson · 2025 · Alzheimer s & Dementia
  7. Generation of iPSC-based human-mouse microglial brain chimeras to study senescence of human microglia
    Mengmeng Jin, Ziyuan Ma, Peng Jiang · 2022 · STAR Protocols
  8. Meta-Analysis of Down Syndrome Cortical Development Reveals Underdeveloped State of the Science
    Risgaard, Kirstin A., Sorci, Isabella A., Mohan, Sruti, Bhattacharyya, Anita · 2022 · Frontiers in Cellular Neuroscience
  9. Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome
    Ishihara, Keiichi · 2021 · Genes
  10. Precision medicine for sodium channelopathy-related autism and epilepsy
    Morgan J. Robinson, Kyle W. Wettschurack, Manasi Suchit Halurkar, Xiaoling Chen, Zaiyang Zhang, Jingliang Zhang, Yang Yang · 2025 · Trends in Molecular Medicine
  11. GABAergic signaling abnormalities in a novel CLU mutation Alzheimer's disease mouse model
    Chunxia Chen, Xihe Tang, Zhaohui Lan, Chen Wan, Hua Su, Weidong Li, Yaoxuan Li, Xing Wang Zhou, Hong Gao, Xinwei Feng et al. · 2023 · Translational research
  12. Modeling SARS-CoV-2 infection in individuals with opioid use disorder with brain organoids
    Moshe J. Willner, Yang Xiao, Hye Sung Kim, Xuejing Chen, Bin Xu, Kam W. Leong · 2021 · Journal of Tissue Engineering
  13. Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids
    Da Wang, Xinyue Zhang, Xiao-Yan Tang, Yixia Gan, Hanwen Yu, Shanshan Wu, Yuan Hong, Mengdan Tao, Chu Chu, Xiaoxuan Qi et al. · 2025 · Cell stem cell
  14. Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts
    William F. Manley, Stewart A. Anderson · 2019 · Cell stem cell
  15. Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cells.
    S. E. Lee, Laura L. Baxter, M. I. Duran, S. D. Morris, Iman A. Mosley, Kevin A. Fuentes, J. Pennings, F. Guedj, Diana W. Bianchi · 2024 · Human Molecular Genetics
  16. Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic
    Changle Fang, Qiulin Wang, Qiu‐Xia Xiao, Xiao-Xing Cai, Ruo‐Lan Du, Lu‐Lu Xue, Xiaohe Tian, Liu‐Lin Xiong · 2025 · Neural Regeneration Research
  17. Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions
    Jin, Mengmeng, Ma, Ziyuan, Zhang, Haiwei, Dang, Rui, Papetti, Ava V., Stillitano, Alessandro C., Zou, Lisa, Goldman, Steven A., Jiang, Peng · 2026 · Cell Reports
  18. In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline
    Marlene F. Pereira, Reinald Shyti, G. Testa · 2024 · Stem Cell Reports
  19. Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders
    Yanru Ji, Jenna Lillie McLean, Ranjie Xu · 2024 · Neuroscience Bulletin
  20. Generation of AAVS1-EGFP reporter cell lines from an isogenic pair of trisomy 21 and euploid human iPSCs
    Vishi Sharma, Sunita Nehra, Nishant Singhal · 2022 · Stem Cell Research
  21. A Comprehensive Update of Cerebral Organoids between Applications and Challenges
    Xiaodong Li, Abdullah Shopit, Jingmin Wang · 2022 · Oxidative Medicine and Cellular Longevity
  22. The Hallmarks of Aneuploidy in Cancer and Congenital Syndromes
    Pan Cheng, Karan Singh, Roger H. Reeves, Teresa Davoli · 2025 · Annual Review of Genomics and Human Genetics
  23. Induced pluripotent stem cell models for advancing neurodevelopmental disorder research and regenerative medicine: a narrative review
    Moawiah M. Naffaa · 2025 · Regenerative medicine reports .
  24. Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model
    Andrew J. Boreland, Yara Abbo, Xindi Li, Alessandro C. Stillitano, Siwei Zhang, Jubao Duan, Zhiping P. Pang, Ronald P. Hart · 2025 · Alcohol
  25. Integrative transcriptome-wide association analyses reveal PRKCG-linked GABAergic dysfunction in Fragile X-associated tremor/ataxia syndrome
    Yulin Jin, Yiqu Cao, Wenjing Ma, Ronghua Li, Yujing Li, Yunhee Kang, Jing Huang, Michael P. Epstein, Xiangxue Guo, Junghwa Lim et al. · 2026 · Nature Communications
  26. A Researcher’s guide to rodent models of Down syndrome: Recent insights and translational perspectives
    Mir Abbas Raza, Andrew Folz, Daniella Balduino Victorino, Zhuo Xing, Xu‐Qiao Chen, Xinxin Zuo, Leah K. Borden, Marie‐Claude Potier, William Cary Mobley, Mara Dierssen et al. · 2026 · STAR Protocols
  27. iPSCs-Derived Neurons and Brain Organoids from Patients
    Wanying Zhu, Lei Xu, Xinrui Li, Hao Hu, Shu-Ning Lou, Yan Liu · 2023 · Handbook of experimental pharmacology
  28. Organoids Modeling Stroke in a Petri Dish
    Chiara Giorgi, Vanessa Castelli, Michele d’Angelo, Annamaria Cimini · 2024 · Biomedicines
  29. Whole Cell Patch Clamp Electrophysiology in Human Neuronal Cells
    Rafael Gabriel, Andrew J. Boreland, Zhiping P. Pang · 2023 · Methods in molecular biology
  30. Recent Development of Brain Organoids for Biomedical Application
    HanSol Kim, Eun Jo Jang, Narendra V. Sankpal, Madhumita Patel, Rajkumar Patel · 2022 · Macromolecular Bioscience
  31. Chromosomal and cellular therapeutic approaches for Down syndrome: A research update
    Tan Huang, Sharida Fakurazi, Pike-See Cheah, King‐Hwa Ling · 2024 · Biochemical and Biophysical Research Communications
  32. A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease
    Mengmeng Jin, Ziyuan Ma, Rui Dang, Haiwei Zhang, Rachael Kim, Haipeng Xue, Jesse R. Pascual, Steven M. Finkbeiner, Elizabeth Head, Ying Min Liu et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial Interactions
    Mengmeng Jin, Ziyuan Ma, Haiwei Zhang, Ava V. Papetti, Rui Dang, Alessandro C. Stillitano, Lisa Zou, Steven A. Goldman, Peng Jiang · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  34. From cells to insights: the power of human pluripotent stem cell-derived cortical interneurons in psychiatric disorder modeling
    Peiyan Ni, Lingyi Fan, Youhui Jiang, Chuqing Zhou, Sangmi Chung · 2023 · Frontiers in Psychiatry
  35. Large-scale trans-ethnic replication and discovery of genetic associations for rare diseases with self-reported medical data
    S. Shringarpure, Wei Wang, Yun-Xuan Jiang, A. Acevedo, Devika Dhamija, Briana Cameron, A. Jubb, Peng Yue, Lea Sarov-Blat, R. Gentleman et al. · 2021 · medRxiv
  36. Application of brain organoids in neurodevelopmental disorders
    Chao Zhao, Yong Qi, Lu Xia, Tengfei Zhu, Kun Xia · 2025 · Biochemical and Biophysical Research Communications
  37. Telomere Biology, Erosion, and Age-Related Conditions: Insights from Down Syndrome and Other Telomere-Associated Disorders
    Enikő Kutasi, Adina Chiş, Mihaela Adela Vințan, Camelia Alkhzouz, Diana Alexandra Văduva, Andreea M. Catana, Romana Vulturar · 2025 · Molecular Neurobiology
  38. Mechanosensor YAP orchestrates human neural rosette morphogenesis via TEAD4-LEF1 transcriptional nexus
    Jinghao Hu, Zan He, Huifang Hu, Xiaoyan Sun, Shanshan Che, Shuhui Sun, Miyang Ma, Yixin Zhang, Shuai Ma, Weiqi Zhang et al. · 2025 · Science China Life Sciences
  39. Pluripotent stem cells-based neural organoids for modelling human brain development and diseases
    Lingling Tong, Peiqi Tian, Ruoxi Wang, Shiyun Niu, Ruoming Wang, Yaxuan Ye, Yuxin Wu, Wenjing Zhang, Yueqi Wang, Angelica Foggetti et al. · 2025 · Cell & Bioscience
  40. Modeling PCDH19-CE: From 2D Stem Cell Model to 3D Brain Organoids
    Rossella Borghi, Valentina Magliocca, Marina Trivisano, Nicola Specchio, Marco Tartaglia, Enrico Bertini, Claudia Compagnucci · 2022 · International Journal of Molecular Sciences
  41. Cellularity Defects Are Not Ubiquitous in the Brains of Fetuses With Down Syndrome
    M. Emili, Fiorenza Stagni, M. Bonasoni, S. Guidi, Renata Bartesaghi · 2024 · Developmental Neurobiology
  42. Hippocampal circuit-specific enhancement of GABA-inhibition caused by discrete gene regions in a Down syndrome model
    S. Hannan, Eva Lana-Elola, Sheona Watson-Scales, Elizabeth M. C. Fisher, Victor L. J. Tybulewicz, Trevor G. Smart · 2025 · bioRxiv
  43. Human neuron chimeric mice reveal impairment of DVL-1-mediated neuronal migration by sevoflurane and potential treatment by rTMS
    Youyi Zhao, Ya Zhao, Lirong Liang, Andi Chen, Yuqian Li, Ke Liu, Rou‐Gang Xie, Honghui Mao, Boyang Ren, Baofu Huang et al. · 2025 · Experimental & Molecular Medicine
  44. Organoids in Genetic Disorders: from Disease Modeling to Translational Applications
    Yuanhang Zhu, Nanshan Lin, Juan Li, Haoqian Zhang, Ping Zhang, Xin Cheng, Qian Yang, Ling Liu · 2025 · Stem Cell Reviews and Reports
  45. A myeloid trisomy 21-associated gene variant is protective from Alzheimer’s disease
    Mengmeng Jin, Ziyuan Ma, Rui Dang, Haiwei Zhang, Rachael Kim, Haipeng Xue, Jesse R. Pascual, Hanwen Yu, Ava V. Papetti, Yàn Liú et al. · 2025 · Nature Neuroscience
  46. White matter aging across the lifespan in Down syndrome: developmental origins, Alzheimer's disease progression, and therapeutic implications
    Justine A. Silva, Jr‐Jiun Liou, Simren Parikh, Natalie C. Edwards, Julia Kofler, Milos D. Ikonomovic, Florence Lai, Herminia Diana Rosas, David K. Powell, Frederick A. Schmitt et al. · 2026 · npj Dementia
  47. Transplantation of Human Brain Organoids into Animals: The Legal Issues
    Nils Hoppe, Maria Lorenz, Johannes Teller · 2022 · Advances in neuroethics
  48. Fragile X Syndrome Patient–Derived Neurons Developing in the Mouse Brain Show FMR1-Dependent Phenotypes
    Marine Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Andrew S. Khalil, Tenzin Lungjangwa, Jennifer Shih et al. · 2021 · Biological Psychiatry
  49. Modeling Down syndrome neurodevelopment with isogenic cerebral organoids
    Jan T. Czerminski, Oliver D. King, Jeanne Bentley Lawrence · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Accelerated Tempo of Cortical Neurogenesis in Down Syndrome
    Jingwen Ding, Chang N. Kim, Marilyn R. Steyert, Andrew T Yuan, David Shin, Dimitar Ivanov, Tomasz Jan Nowakowski, Alex A. Pollen · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Debates on humanization of human-animal brain chimeras – are we putting the cart before the horses?
    Bor Luen Tang · 2024 · Medicine Health Care and Philosophy
  52. Lamivudine modulates the expression of neurological impairment-related genes and LINE-1 retrotransposons in brain tissues of a Down syndrome mouse model
    Alessandra Borgognone, María Casadellà, María Martínez de Lagrán, Roger Paredes, Bonaventura Clotet, Mara Dierssen, Aleix Elizalde‐Torrent · 2024 · Frontiers in Aging Neuroscience
  53. Amelioration of biased neuronal differentiation in humanized mouse model of valproic acid‐induced autism by precisely targeted transcranial magnetic stimulation
    Yilin Hou, Youyi Zhao, Dingding Yang, Tingwei Feng, Yuqian Li, Xiang Li, Zhou'an Liu, Xiao‐Jie Yan, Hui Zhang, Sheng‐Xi Wu et al. · 2025 · Bioengineering & Translational Medicine
  54. REST deficiency and neurogenic-to-gliogenic shift in down syndrome human cerebral organoids
    Tan Huang, Chong-Teik Lim, Wei Li, S Fakurazi, John O. Mason, Pike-See Cheah, Yi Li, King‐Hwa Ling · 2026 · Molecular Brain
  55. Des organoïdes cérébraux pour la compréhension et la thérapie des maladies génétiques rares avec troubles neurodéveloppementaux
    Fatima El It, Laurence Olivier Faivre, Christel Thauvin‐Robinet, Antonio Vitobello, Laurence Duplomb · 2024 · médecine/sciences
  56. Modeling Down Syndrome Neurodevelopment with Dosage Compensation
    Jan T. Czerminski · 2019 · eScholarship@UMassChan
  57. Cerebral Organoids: A Model of Brain Development
    Kirill K. Sukhinich, M. A. Aleksandrova · 2020 · Russian Journal of Developmental Biology
  58. Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease
    Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra Cadete Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  59. Genetics of cortical development
    Daniela J. Di Bella, Ehsan Habibi · 2022 · Elsevier eBooks
  60. NeuID, a novel neuron-specific lncRNA, resolves a key epigenetic mechanism linking gene silencing to Alzheimer’s disease
    Ranjit Pradhan, Zorica Petrovic, M. Sadman Sakib, Sophie Schröder, Dennis Manfred Krüger, Tonatiuh Peña, Eren Diniz, Susanne Burckhardt, Anna‐Lena Schütz, Iga Grządzielewska et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  61. Modeling Prenatal Immune Activation in Human Brain Organoids Uncovers IL-6–Dependent Interneuron Dysmaturation
    Ava V. Papetti, Ziyuan Ma, Michelle Ng, Mengmeng Jin, Steven W. Levison, Peng Jiang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer’s tau pathology and uncover human-specific neuronal vulnerability
    Yanru Ji, Purba Mandal, Jiahui Liu, Wen Hu, Bryce David Colon, Changlin Wan, Raymond W. Pan, Dongkai Guo, Lijia Zhang, Xingjian Gu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  63. A bit too much Olig2 in Down’s syndrome
    Ming Hui Yang · 2019 · Science Translational Medicine
  64. An empirical bayesian approach for testing gene expression fold change and its application in detecting global dosage effects
    Zhenxing Guo, Ying Cui, Xiaowen Shi, James A. Birchler, Igor Albizua, Stephanie L. Sherman, Zhaohui Steve Qin, Tieming Ji · 2020 · NAR Genomics and Bioinformatics
  65. Pluripotent stem cell–derived brain-region-specific organoids
    Phuong Trang Nguyen, Hongjun Song, Guo‐li Ming · 2021 · Elsevier eBooks
  66. Human induced pluripotent stem cell modeling of neurofibromatosis type 1
    Sarah V. Schurr, Kelly A. Hartigan, David H. Gutmann · 2021 · Elsevier eBooks
  67. Human-mouse chimeric Fragile X syndrome model reveals FMR1-dependent neuronal phenotypes
    Marine Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Aaron N. Chang, Stephen T. Warren, Angela M. Cacace et al. · 2020 · Research Square
  68. In vivo and in vitro models for research on Down syndrome
    Bani Bandana Ganguly · 2022 · Elsevier eBooks
  69. Gene editing hPSCs for modeling neurological disorders
    Andrew J. Petersen · 2022 · Elsevier eBooks
  70. Realizing the potential of exploiting human IPSCs and their derivatives in research of Down syndrome
    Y. Wang, Jielei Ni, YUHAN LIU, Ding-Ying Liao, Qianwen Zhou, Xiaoyang Ji, GANG NIU, Yanxiang Ni · 2023 · Biocell
  71. Human Models of Down Syndrome
    Megan Jandy, Hao Hu, Yan Liu, Anita Bhattacharyya · 2025 · Springer eBooks
  72. The promise of cerebral organoids for neonatology
    Clare E. Howard, Manju Cheenath, Elizabeth Erin Crouch · 2025 · Current Opinion in Pediatrics
  73. Down Syndrome: Progress in Defining Pathogenesis and Treatments for Neurodevelopmental Deficits and Alzheimer’s Disease
    Renata Bartesaghi, Xu‐Qiao Chen, Aaron D. Johnstone, Utpal Das, William Cary Mobley · 2025 · Springer eBooks
  74. Microphysiological Systems: Advancing Insights into Brain Development and Disorders
    Farjana Yasmin, Rodrigo Cristofoletti, Janny Piñeiro-Llanes · 2025 · IntechOpen eBooks
  75. Nonsense, but not frameshift, truncating mutations result in Cyclin D2 stabilisation in an induced pluripotent stem cell model of MPPH
    Erica L. Harris, Rowan D. Taylor, Katarzyna Szymańska, Ailsa M.S. Rose, Jacquelyn Bond, Colin A. Johnson, James A. Poulter · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Protocol for purifying primitive neural progenitors by fractional passaging to generate astroglia-enriched cerebral organoid
    Kushal Aluru, Rui Dang, Mengmeng Jin, Peng Jiang · 2025 · STAR Protocols
  77. Additional file 11 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Groveman, Bradley R., Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  78. Additional file 19 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  79. Additional file 10 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Groveman, Bradley R., Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  80. Additional file 16 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  81. Additional file 14 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  82. Additional file 1 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  83. Additional file 13 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  84. Additional file 9 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  85. Additional file 15 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  86. Additional file 17 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  87. Stem cell-based organoid culture system as an innovative model of the central nervous system development and disease system
    Mycal Dutta, Md. Mustafiz Chowdhury, Mohsin Kazi, Mayeen Uddin Khandaker · 2025 · Elsevier eBooks
  88. Additional file 8 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  89. Additional file 18 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  90. Additional file 12 of Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases
    Simote Totauhelotu Foliaki, Benjamin H. Schwarz, Bradley R. Groveman, Ryan O. Walters, Ferreira, Natalia C., Christina Doriana Orru, Smith, Anna, Aleksandar R. Wood, Olivia M. Schmit, Phoebe Freitag et al. · 2021 · Figshare
  91. Selective chr21 homolog silencing reveals polymorphisms influence the epigenetic silencing and functional dosage of RWDD2B
    Eric C. Larsen, Jennifer E. Moon, Oliver D. King, Jeanne Bentley Lawrence · 2026 · The American Journal of Human Genetics
  92. Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome
    Marta Boira Marti, Sean D. Morrison, Selin Pars, Bahaa Al-mhanawi, Peter G. Noakes, Ernst Jurgen Wolvetang, Mohammed R. Shaker · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  93. Human brain cellular xenografts in neuroimmunology and beyond
    Nicola Fattorelli, Anna Martínez‐Muriana, Victor Hugh Perry, Renzo Mancuso · 2026 · Immunity