Circadian Entrainment Triggers Maturation of Human In Vitro Islets

Alvarez-Dominguez, Juan R., Donaghey, Julie, Rasouli, Niloofar, Kenty, Jennifer H.R., Helman, Aharon, Charlton, Jocelyn, Straubhaar, Juerg R., Meissner, Alexander +1 more·2020·Cell Stem Cell

Cited by (165)

Items 101–165 of 165

  1. The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis
    Daniel Veronese-Paniagua, Jeffrey R. Millman · 2025 · Frontiers in Endocrinology
  2. FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction
    Clarissa Tacto, Meghan Tahbaz, Andrew Salib, Shudi Wang, Fritz Cayabyab, Jin‐Hyuk Choi, K. A. Kim, Yu Hamba, H. Daniel Perez, Paul David Gershon et al. · 2025 · Nature Communications
  3. Therapeutic potential of stem cell‐derived somatic cells to treat metabolic dysfunction‐associated steatotic liver disease and diabetes
    Eduardo Hideo Gilglioni, Mayank Bansal, Wadsen St‐Pierre‐Wijckmans, Stephanie Talamantes, Alvile Kasarinaite, David C. Hay, Esteban N. Gurzov · 2025 · Obesity Reviews
  4. Ameliorating and refining islet organoids to illuminate treatment and pathogenesis of diabetes mellitus
    Yushan Li, Mei-Qi Xu, Jia-Li Chen, Jian-Song Huang, Jia-Ying Cao, Huajing Chen, Jiayi Zhang, Yu-Kun Luo, Ya-Zhuo Wang, Jia Sun · 2024 · Stem cell research & therapeutics
  5. Cyborg islets: implanted flexible electronics reveal principles of human islet electrical maturation
    Qiang Li, Ren Liu, Zuwan Lin, Xinhe Zhang, Israeli M. Galicia-Silva, Samuel D. Pollock, Juan R. Alvarez‐Dominguez, Jia Liu B · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Multiplexed CRISPR gene editing in primary human islet cells with Cas9 ribonucleoprotein
    R. Bevacqua, Wei-Chen Zhao, Emilio Merheb, S. Kim, A. Marson, A. Gloyn, Seung K. Kim · 2023 · bioRxiv
  7. The Values and Perspectives of Organoids in the Field of Metabolic Syndrome
    Tan Chen, Min Ding, Yun‐Wen Zheng · 2023 · International Journal of Molecular Sciences
  8. Tracking insulin- and glucagon-expressing bihormonal cells during differentiation using an INSULIN and GLUCAGON double reporter human embryonic stem cell line
    Samantha Mar, Ekaterina Filatov, Cuilan Nian, Shugo Sasaki, Dahai Zhang, Francis C. Lynn · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  9. Engineering-inspired approaches to study β-cell function and diabetes
    Phillip L. Lewis, James M. Wells · 2021 · Stem Cells
  10. Cardiac circadian rhythms in time and space: The future is in 4D.
    N. Chirico, L. V. Van Laake, J. Sluijter, A. van Mil, Pieterjan Dierickx · 2020 · Current opinion in pharmacology (Print)
  11. Pre-adaptation of stem cell-derived islet organoids to hypoxia via zinc transportation inhibition drives angiogenesis
    Zhaoyue Wang, Minglu Xu, Rui Hu, Xiangyi Chen, Xushu Wang, Guangyu Shi, Sirun Lu, Yiling Yang, Yajuan Su, Mengting Gong et al. · 2026 · Cell stem cell
  12. Noncanonical clock regulators control stress responses in digestive diseases
    Dishu Zhou, Roberto E López-Valiente, Samer Gamil Mattar, Dongyin Guan · 2025 · Trends in Endocrinology and Metabolism
  13. Supragel-mediated efficient generation of pancreatic progenitor clusters and functional glucose-responsive islet-like clusters
    Hong Ma, Lilin Xu, Shengjie Wu, Song Wang, Jie Li, Si-Fan Ai, Zhuangzhuang Yang, Rigen Mo, Lei Lin, Yan Li et al. · 2024 · Bioactive Materials
  14. Truncated CD19 as a selection marker for the isolation of stem cell-derived β-cells
    Helen Huang, Ruize Gao, Dahai Zhang, Cuilan Nian, Willem Martzke, A. M. James Shapiro, Tatsuya Kin, Yaser Tahamtani, Francis C. Lynn · 2025 · Disease Models & Mechanisms
  15. T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
    Alexandro Landshammer, Adriano Bolondi, H. Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, S. Mackowiak, B. Braendl, Pay Giesselmann et al. · 2023 · eLife
  16. Designing next-generation islet-like cells from human pluripotent stem cells: Advances in overcoming allorejection and recurrent type 1 Diabetes
    Paraish S. Misra, M. Nostro · 2022 · Current Opinion in Endocrine and Metabolic Research
  17. The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D risk
    Chun Su, Long Gao, Catherine May, J. Pippin, Keith Boehm, Michelle Y. Y. Lee, Cheng-Yang Liu, Matthew C. Pahl, M. Golson, A. Naji et al. · 2021 · bioRxiv
  18. Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects
    Xing Jian, G. Felsenfeld · 2021 · Nature Communications
  19. Effect of Sonic hedgehog pathway inhibition on PDX1 expression during pancreatic differentiation of human embryonic stem cells
    Prasad Pethe, Niloufer P. Dumasia, D. Bhartiya · 2021 · Molecular Biology Reports
  20. Purification of Live Stem Cell-Derived Islet Lineage Intermediates
    Niloofar Rasouli, D. Melton, J. Alvarez-Dominguez · 2020 · Current protocols in stem cell biology
  21. Regenerative medicine approaches for treating diabetes: Current advances and future directions
    Sanja Medenica, Džihan Abazović, Jovana Vuković, Tanja Vojinović, Filip Tomović, Giuseppe Defeudis, Rossella Mazzilli, Zlata Kovačević, Dusan Djurdjic, Vladimir Prelević et al. · 2025 · Journal of Diabetes and its Complications
  22. Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes
    Muhammad Usama, Ying Deng, Yiran Chen, Théa Milland, Mohan K. Malleshaiah, Yasaman Aghazadeh · 2025 · Frontiers in Immunology
  23. Transient gene melting governs the timing of oligodendrocyte maturation
    Kevin C. Allan, Jesse J. Zhan, A. Morton, Erin F. Cohn, Marissa A. Scavuzzo, Anushka Nikhil, Matthew S. Elitt, Benjamin L. L. Clayton, Lucille R. Hu, H. Shick et al. · 2025 · Cell
  24. Photostimulation improves maturation of human photoreceptors
    Canan Celiker, Eva Hrubá, Konstantina Kyriakou, Birthe Dorgau, Francisco Molina Gambin, Kamila Weissová, Edwin van Oosten, Lucie Englmaier, Naděžda Vaškovicová, Michael A. Savage et al. · 2026 · Nature Communications
  25. Core circadian transcription factor Bmal1 mediates β cell response and recovery from pro-inflammatory injury
    Kuntol Rakshit, Matthew Brown, Naureen Javeed, Jeong‐Heon Lee, Tamás Ördög, Aleksey V. Matveyenko · 2024 · iScience
  26. Circadian regulation of lung repair and regeneration.
    A. Naik, K. Forrest, Oindrila Paul, Yasmine Issah, U. Valekunja, S. Tang, A. B. Reddy, Elizabeth J. Hennessy, Thomas G. Brooks, Fatima N. Chaudhry et al. · 2024 · JCI Insight
  27. Inferring regulators of cell identity in the human adult pancreas
    Lotte Vanheer, Federica Fantuzzi, San Kit To, Andréa Alex Schiavo, Matthias Van Haele, Tessa Ostyn, Tine Haesen, Xiaoyan Yi, Adrian Janiszewski, Joel Chappell et al. · 2023 · NAR Genomics and Bioinformatics
  28. Cellular Maturation of Oligodendrocytes is Governed by Transient Gene Melting
    Kevin C. Allan, Tyler E. Miller, A. Morton, Marissa A. Scavuzzo, Matthew S. Elitt, Benjamin L. L. Clayton, Lucille R. Hu, Jost K. Vrabic, Hannah E. Olsen, D. Factor et al. · 2022 · bioRxiv
  29. Defining the chromatin and transcriptional landscape of stem cell-derived islets
    Punn Augsornworawat, N. Hogrebe, Matthew Ishahak, Erica Marquez, Marlie M. Maestas, Mason D. Schmidt, Daniel A. Veronese-Paniagua, S. Gale, Julia R. Miller, Leonardo Velazco-Cruz et al. · 2022 · bioRxiv
  30. The Ldb1 transcriptional co-regulator is required for establishment and maintenance of the pancreatic endocrine lineage
    Eliana Toren, Yan-Ping Liu, M. Bethea, Alexa K. Wade, Chad S. Hunter · 2022 · The FASEB Journal
  31. Adapting Physiology in Functional Human Islet Organogenesis
    Eiji Yoshihara · 2022 · Frontiers in Cell and Developmental Biology
  32. Effect of isoproterenol, a β-adrenergic agonist, on the differentiation of insulin-producing pancreatic β cells derived from human pluripotent stem cells.
    Hye Ryeong Jun, Y. Kim, Ji Eun Moon, Sehui Jeong, Han-Se Goh, H. Hoang, Yu-Na Lee, Hyemin Jeong, I. Shim, Song Cheol Kim · 2024 · Experimental Cell Research
  33. A trio of biological rhythms and their relevance in rhythmic mechanical stimulation of cell cultures
    D. Kwak, P. A. Olsen, A. Danielsen, Alexander Refsum Jensenius · 2022 · Frontiers in Psychology
  34. Developmental cell fate choice employs two distinct cis regulatory strategies
    M. Delás, Christos M Kalaitzis, Tamara Fawzi, Madeleine Demuth, Isabel Zhang, H. Stuart, Elena Costantini, K. Ivanovitch, Elly M. Tanaka, J. Briscoe · 2022 · bioRxiv
  35. HASTER is a transcriptional stabilizer of HNF1A
    Anthony Beucher, I. Miguel-Escalada, D. Balboa, Matías G. De Vas, M. Maestro, J. García-Hurtado, Aina Bernal, Roser Gonzalez-Franco, P. Vargiu, H. Heyn et al. · 2021 · bioRxiv
  36. Predicting the Key Regulators of Cell Identity in Human Adult Pancreas
    Lotte Vanheer, F. Fantuzzi, San-Kit To, A. Schiavo, M. Van Haele, Tine Haesen, Xiaoyuan Yi, A. Janiszewski, J. Chappell, Adrien Rihoux et al. · 2020 · bioRxiv
  37. MAFA: A Master Regulator of β-Cell Maturation and Function
    Lizabeth Johnson, Mallory A. Maurer, Jeeyeon Cha · 2026 · Cells
  38. Stem cell therapies for treatment of diabetes mellitus
    Feng Guo, Yi Song, Guijun Qin · 2026 · Chinese Medical Journal
  39. Tissue‐Stimulator Platform for Electrically Stimulating Pancreatic β‐Cells for Long‐Term Functional Regulation
    Jihwan Kim, U. Yong, Myungji Kim, Jaewook Kim, Yeonggwon Jo, I. Shim, Song Cheol Kim, Jin-Ah Jang · 2026 · Advanced Functional Materials
  40. Single-cell multi-omic analyses highlight the essential role of NKX2.2-CLEC16A/endosomal pathway for human pancreatic differentiation and function
    Guo Chen, Xiaojie Ma, Liling Jiang, Ziyu Zhou, Qin Li, Qian Deng, Yuhan Li, Yueqing He, Yixin Wang, Xiaohao Wang et al. · 2026 · Cell Reports
  41. Models of myeloma bone disease: In vivo and in vitro approaches.
    Jiaxian Wang, Sonja Zweegman, R. Groen · 2026 · Bone
  42. DEC1 regulates human β cell functional maturation and circadian rhythm
    Sam Preza, Bliss Zheng, Zihan Gao, A. Biju, Mai Liu, Zhihui Cheng, Matthew Choi, Juan R. Alvarez-Dominguez · 2025 · Cell Reports
  43. Safeguarding genomic integrity in beta-cells: implications for beta-cell differentiation, growth, and dysfunction
    Sneha S. Varghese, Alessandro Giovanni Hernandez-De La Peña, Sangeeta Dhawan · 2024 · Biochemical Society Transactions
  44. Retrieval and purification of human β cells from stem cell-derived islet engrafted mice
    Jennifer H. R. Kenty, G. C. Pelayo, N. Leite · 2021 · STAR Protocols
  45. A window in time for β-cell regeneration
    Benjamin J. Weidemann, Joseph T. Bass · 2020 · Genes & Development
  46. Evaluation of Alvarez-Dominguez et al.: Circadian Entrainment Triggers Maturation of Human In Vitro Islets.
    B. Andersen, Zi-Guang Lin · 2020 · Cell Stem Cell
  47. A prioritized medium-throughput screen identifies fibroblast growth factors as protective for human stem cell derived insulin secreting beta cells
    Chieh Min Jamie Chu, Sepehr Kamal, Luo-Ting Huang, Carmen L. Bayly, Maria J. Beletsky, Samantha Mar, Sing-Young Chen, Meltem E. Omur, W. Wasserman, Francis C. Lynn et al. · 2026 · bioRxiv
  48. Rapid metabolic control after primary islet transplantation: relevance for stem cell-derived islet product development
    Juan R. Alvarez-Dominguez, Mai Liu, Carla Sawan, S. Soleimanpour, Cheng-Yang Liu, A. Naji, M. Rickels · 2026 · Transplant International
  49. Toward adaptive cyborg tissues.
    Qiang Li, J. Lunshof, Jia Liu · 2026 · Trends in Biotechnology
  50. Summary Report of the Fifth International Pancreas and Islet Transplant Association Summit on Stem Cell-derived Islets.
    J. Odorico, A. Citro, E. D. de Koning, T. Kay, E. Latres, J. Millman, M. Nostro, L. Piemonti, M. Rickels, Holger A. Russ et al. · 2026 · Transplantation
  51. MAFA drives pancreatic islet maturation through coordination of cell growth, metabolic maturation, and resilience to stress
    Veronica A. Cochrane, Michael Sterr, Marianne Aniag, Sara Jiménez, Madeline S. Wang, Ying Liu, Alena Boos, Juliane Merl‐Pham, Aarti Anand, Ryan E. Hoang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Protective IFIH1 variant reduces islet stress and dysfunction in a type 1 diabetes genetic background
    Daniel Veronese-Paniagua, Cameron E Banks, Kameron Bradley, Noyonika Mukherjee, Sarah E. Gale, Kate E. Hinshaw, Amy M. Meacham, Opeoluwa F Iwaloye, Hubert Ming Tse, Clayton E. Mathews et al. · 2026 · iScience
  53. The comparative cell physiology of stem cell-derived and primary human β cells
    Jasmine Maghera, Chieh Min Jamie Chu, Christopher Schaaf, Jennifer E. Bruin, James D. Johnson, Francis C. Lynn, Patrick E. MacDonald · 2026 · Nature Reviews Endocrinology
  54. Epigenetics in development, disease, and therapy: from mechanisms to clinical interventions
    Yixuan Ren, Lei Yang, Boyi Fei, Rong Guo, Junran Huang, Zhenghao Xu, Ruoran Wang, Pinqi Zhang, Dandan Cao, Pan Chen et al. · 2026 · Science China Life Sciences
  55. Pancreatic organoids and organoid-on-a-chip platforms: from disease modeling to precision therapy
    Mengran Lin, Wei Ma, Teng Ma, Yanjie He, Huan Shi, Nan Ge, Jintao Guo, Ying Xie, Siyu Sun, Fan Yang · 2026 · Journal of Translational Medicine
  56. Designing complex organoids through developmental principles
    Jonathan A. Brassard, James M. Wells · 2026 · Cell stem cell
  57. Epigenetic Profiling of Human Insulinomas Reveals AP-1 Family as Critical Regulators of Beta Cell Maturation
    Xuedi Wang, S. Carcamo, L. Lambertini, P. Wang, Hong-Tao Liu, John D. Paulsen, R. Brody, Gustavo Fernandez-Ranvier, D. Hasson, A. Stewart et al. · 2026 · bioRxiv
  58. Impaired cohesin loading disrupts pancreatic differentiation by Polycomb-driven chromatin rewiring and loop collapse
    Long-Tao Yu, Yayu Liu, Jie Zhang, Chaofan Huang, Huanyu Feng, XueXue Zhao, Shiyu Feng, Wenqian Gong, Xiaowen Lyu · 2026 · Communications Biology
  59. DBSOMA: A Machine Learning Method that Identifies Chemical Modulators of Transcriptional States Uncovers Effectors of Beta-Cell Maturation
    Timothy R Kunz, José Rivera-Feliciano · 2026 · bioRxiv
  60. Circadian regulation of insulin secretion in transplanted human stem cell-derived pancreatic β-cells
    Satish Sen, Zenith Khashim, Sharath Belame Shivakumar, Shaimaa Hassoun, Tiana Salomon, Sean Lewis-Brinkman, Matthew Brown, Luhui Zhang, Quinn P. Peterson, Aleksey V. Matveyenko · 2025 · Stem Cell Reports
  61. Embryonic Circadian Rhythm Establishment, Homeostasis, and Dysfunction During Organogenesis
    Si-Lin Chen, Hang Zhou, Yu-Mei Li, Yun-Wen Zheng · 2025 · Stem Cells International
  62. Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms
    Cristiane dos Santos, S. Shrestha, Matthew A. Cottam, Guy Perkins, V. Lev-Ram, Birbickram Roy, Christopher Acree, Keun-Young Kim, Thomas Deerinck, Melanie Cutler et al. · 2023 · Research Square
  63. Discovery and characterization of LNCSOX17 as an essential regulator in human endoderm formation
    Alexandro Landshammer, Adriano Bolondi, H. Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, S. Mackowiak, B. Braendl, Pay Giesselmann et al. · 2022 · bioRxiv
  64. Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen
    Biliana Marcheva, Benjamin J Weidemann, A. Taguchi, Mark Perelis, K. Ramsey, M. Newman, Yumiko Kobayashi, Chiaki Omura, J. E. Manning Fox, Hao-Peng Lin et al. · 2021
  65. Organoid Maturation by Circadian Entrainment
    J. Alvarez-Dominguez, Julie Donaghey, Niloofar Rasouli, Jennifer H. R. Kenty, Aharon Helman, J. Charlton, J. Straubhaar, A. Meissner, D. Melton · 2020 · StemJournal