The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
Open accessAbstract
SUMMARY N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be frequently deleted, implying a tumor-suppressor role. Here, we show that ALKBH5 deletion is rare in human AML; instead, ALKBH5 is aberrantly overexpressed in AML. Moreover, its increased expression correlates with poor prognosis in AML patients. We demonstrate that ALKBH5 is required for the development and maintenance of AML and self-renewal of leukemia stem/initiating cells (LSCs/LICs), but not essential for normal hematopoiesis. Mechanistically, ALKBH5 exerts tumor-promoting effects in AML by post-transcriptional regulation of its critical targets such as TACC3, a prognosis-associated oncogene in various cancers. Collectively, our findings reveal essential functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance, and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
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Self-citationFunctional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
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Self-citationALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Jiang, X., Liu, B., Nie, Z., Duan, L., Xiong, Q., Jin, Z., Yang, C., & Chen, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00450-x · Cited by 2,335
Self-citationTumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
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Self-citationTumor hypoxia: From basic knowledge to therapeutic implications
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Metadata
- Authors
- Shen, C., Sheng, Y., Zhu, A. C., Robinson, S., Jiang, X., Dong, L., Chen, H., Su, R., Yin, Z., Li, W., Deng, X., Chen, Y., Hu, Y.-C., Weng, H., Huang, H., Prince, E., Cogle, C. R., Sun, M., Zhang, B., Chen, C.-W., Marcucci, G., He, C., Qian, Z., & Chen, J.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 27
- Issue
- 1
- Pages
- 64-80.e9
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- OpenAlex
- W3026033619
- Cited by
- 373
- References
- 79
- FWCI
- 16.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shen, C., Sheng, Y., Zhu, A. C., Robinson, S., Jiang, X., Dong, L., Chen, H., Su, R., Yin, Z., Li, W., Deng, X., Chen, Y., Hu, Y.-C., Weng, H., Huang, H., Prince, E., Cogle, C. R., Sun, M., Zhang, B., . . . Chen, J. (2020). RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia. Cell Stem Cell. https://doi.org/10.1016/j.stem.2020.04.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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