Type-I-interferon signaling drives microglial dysfunction and senescence in human iPSC models of Down syndrome and Alzheimer’s disease
Jin, Mengmeng, Xu, Ranjie, Wang, Le, Alam, Mahabub Maraj, Ma, Ziyuan, Zhu, Sining, Martini, Alessandra C., Jadali, Azadeh +8 more·2022·Cell Stem Cell
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- Microglia drive synaptic and functional connectivity deficits in the Ts65Dn mouse model of Down syndrome by affecting inhibitionAlexia Tiberi, Elena Montagni, Giulia Borgonovo, Éléa Coulomb, Laura Restani, Anna Letizia Allegra Mascaro, Simona Capsoni, Antonino Cattaneo · 2025 · Acta Neuropathologica Communications
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- Astroglial Activation Is Exacerbated in a Down Syndrome Mouse ModelZuolin Zhou, Yanhua Bi, Chunchun Zhi, Siqi Chen, Die Chen, Zhen Cheng Wei, Xiaoling Jiang · 2024 · Neuroscience
- Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoidsAndrew J. Boreland, Alessandro C. Stillitano, Hsin-Ching Lin, Yara Abbo, Ronald P. Hart, Peng Jiang, Zhiping P. Pang, Arnold B. Rabson · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysisOliver Jonathan Ziff, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder K. Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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- A human fetal cerebellar map of the late second trimester reveals developmental molecular characteristics and abnormality in trisomy 21Hongmin Yu, Yun Liu, Fanqing Xu, Yuanyuan Fu, Ming Yang, Ling Ding, Yixuan Wu, Fuchou Tang, Jie Qiao, Lu Wen · 2024 · Cell Reports
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- Advances in hiPSC ‐Derived Brain Organoids as a Model to Study Neuroinflammation in Alzheimer's DiseaseEsther M. A. Maciel, Nathalia Costa Silva, Luiz Gustavo Pontes Santos, Fabiola Mara Ribeiro · 2026 · Journal of Neurochemistry
- Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's DiseasePatricia Martínez-Tazo, Marina Mejias‐Ortega, Verónica López-López, Aysha María Bhojwani-Cabrera, Emma Saxton, Santiago Canals, Giles E. Hardingham, Antonia Gutiérrez, José P. López‐Atalaya, Silvia De Santis · 2026 · European Journal of Neuroscience
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- The versatile applications of human pluripotent stem cell-derived microglia and microglia-containing brain organoidsJunjiao Wu, Yu Tang · 2023 · Ageing and Neurodegenerative Diseases
- Origin, Diversity, and Roles of MicrogliaLaurence Ris · 2024 · Springer eBooks
- Human Down syndrome microglia are up for a synaptic feastFerdi Rıdvan Kiral, In‐Hyun Park · 2022 · Cell stem cell
- Type I interferon signaling enhances kainic acid-induced seizure severityJeong-Hwa Ma, Jun-Cheol Eo, Changjun Lee, Inhwa Hwang, Ji-Hye Choi, Sung Jae Shin, Chul Hoon Kim, Je‐Wook Yu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
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- Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric BrainsMengmeng Jin, Ziyuan Ma, Rui Dang, Haiwei Zhang, Haipeng Xue, Steven M. Finkbeiner, Ying Liu, Peng Jiang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Microglia and innate immunity in Alzheimer’s diseaseYoki Nakamura · 2023 · Folia Pharmacologica Japonica
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- Origin, Diversity, and Roles of MicrogliaLaurence Ris · 2024 · Springer eBooks
- Human Models of Down SyndromeMegan Jandy, Hao Hu, Yan Liu, Anita Bhattacharyya · 2025 · Springer eBooks
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- Additional file 2 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeZhenglong Guo, Zhu, Yongchang, Hai Xiao, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2024 · Figshare
- Additional file 9 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeZhenglong Guo, Zhu, Yongchang, Xiao, Hai, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2024 · Figshare
- Additional file 6 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeZhenglong Guo, Zhu, Yongchang, Xiao, Hai, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2024 · Figshare
- Additional file 5 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeZhenglong Guo, Zhu, Yongchang, Xiao, Hai, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2024 · Figshare
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- Additional file 4 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeZhenglong Guo, Zhu, Yongchang, Xiao, Hai, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2024 · Figshare
- Additional file 3 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeGuo, Zhenglong, Zhu, Yongchang, Xiao, Hai, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, 廖世秀 · 2024 · Figshare
- Additional file 7 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeZhenglong Guo, Zhu, Yongchang, Xiao, Hai, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2024 · Figshare
- Additional file 1 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeZhenglong Guo, Zhu, Yongchang, Hai Xiao, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2023 · Figshare
- Additional file 8 of Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndromeGuo, Zhenglong, Zhu, Yongchang, Xiao, Hai, Dai, Ranran, Yang, Wenke, Wei Xue, Zhang, Xueying, Hao, Bingtao, Liao, Shixiu · 2024 · Figshare
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