Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons
Open accessAbstract
In this issue of Cell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer's disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importance of these brain-resident immune cells and highlighting a novel pathway for therapeutic intervention.
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Microglia harboring an APOE4 allele show altered cellular metabolism, increasing intracellular and extracellular lipid accumulation.
“Microglia harboring an APOE4 allele showed altered cellular metabolism, increasing intracellular and extracellular lipid accumulation.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [197]
Extracellular lipid droplets directly decrease neuronal activity by increasing inward K+ currents.
“The extracellular lipid droplets directly decreased neuronal activity by increasing inward K+ currents.”
From Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets (2023) · cites this paper as [197]
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References 9 · Cited by 10
- Authors
- Young, J. E., & Jayadev, S.
- Affiliations
- University of Washington (US)
- Corresponding author
- Young, Jessica E.
- Venue
- Cell Stem Cell
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 29
- Issue
- 8
- Pages
- 1159-1160
- ISSN
- 1875-9777 (ISSN-L)
- 1934-5909
- PMC
- PMC12495995
- OpenAlex
- W4289793566
- Cited by
- 10
- References
- 9
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell stem cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Institute on Aging (R01AG062148)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- APOE ε4, microglia, lipid metabolism, Alzheimer's disease, neuronal network activity, microglial activation, neuroinflammation
- MeSH terms
- Alzheimer Disease, Brain, Humans, Neurons, Microglia, Lipid Metabolism, Apolipoprotein E4
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