CoChat
Sign Up
Cited by 227Mesenchymal stem cell researchAsthma and respiratory diseasesExtracellular vesicles in disease

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation

Open access
Yao, Yin, Fan, Xing-Liang, Jiang, Dan, Zhang, Yuelin, Li, Xin, Xu, Zhi-Bin, Fang, Shu-Bin, Chiu, Sinming, Tse, Hung-Fat, Lian, Qizhou, Fu, Qing-Ling·2018·Stem Cell Reports
DOI 10.1016/j.stemcr.2018.09.012PMC PMC6234920
Open this paper in CoChat — free accountOpen PDF

Abstract

We previously identified an immunomodulatory role of human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (MSCs) in asthmatic inflammation. Mitochondrial transfer from bone marrow MSCs to epithelial cells can result in the attenuation of acute lung injury in mice. However, the effects of mitochondrial transfer from iPSC-MSCs to epithelial cells in asthma and the mechanisms underlying these effects are unclear. We found that iPSC-MSC transplantation significantly reduced T helper 2 cytokines, attenuated the mitochondrial dysfunction of epithelial cells, and alleviated asthma inflammation in mice. Tunneling nanotubes (TNTs) were formed between iPSC-MSCs and epithelial cells, and mitochondrial transfer from iPSC-MSCs to epithelial cells via TNTs was observed both in vitro and in mice. Overexpression or silencing of connexin 43 (CX43) in iPSC-MSCs demonstrated that CX43 plays a critical role in the regulation of TNT formation by mediating mitochondrial transfer between iPSC-MSCs and epithelial cells. This study provides a therapeutic strategy for targeting asthma inflammation.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.stemcr.2018.09.012

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 42

  1. Ahmad, 2014, Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy, EMBO J., 33, 994
  2. Antunes, 2014, Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema, Respir. Res., 15, 118, 10.1186/s12931-014-0118-x · DOI
  3. Bonios, 2011, Myocardial substrate and route of administration determine acute cardiac retention and lung bio-distribution of cardiosphere-derived cells, J. Nucl. Cardiol., 18, 443, 10.1007/s12350-011-9369-9 · DOI
  4. Cao, 2010, Activation of human bronchial epithelial cells by inflammatory cytokines IL-27 and TNF-alpha: implications for immunopathophysiology of airway inflammation, J. Cell Physiol., 223, 788, 10.1002/jcp.22094 · DOI
  5. Chan, 2017, Aeroallergens induce reactive oxygen species production and DNA damage and dampen antioxidant responses in bronchial epithelial cells, J. Immunol., 199, 39, 10.4049/jimmunol.1600657 · DOI
  6. Chuang, 2017, Mitochondrial transfer from Wharton's jelly mesenchymal stem cell to MERRF cybrid reduces oxidative stress and improves mitochondrial bioenergetics, Oxid. Med. Cell. Longev., 2017, 5691215, 10.1155/2017/5691215 · DOI
  7. Crisostomo, 2006, High passage number of stem cells adversely affects stem cell activation and myocardial protection, Shock, 26, 575, 10.1097/01.shk.0000235087.45798.93 · DOI
  8. Cruz, 2015, Systemic administration of human bone marrow-derived mesenchymal stromal cell extracellular vesicles ameliorates Aspergillus hyphal extract-induced allergic airway inflammation in immunocompetent mice, Stem Cells Transl. Med., 4, 1302, 10.5966/sctm.2014-0280 · DOI
  9. Dai, 2017, Delivery of adipose-derived mesenchymal stem cells attenuates airway responsiveness and inflammation in a mouse model of ovalbumin-induced asthma, Am. J. Transl. Res., 9, 2421
  10. de Castro, 2017, Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma, Stem Cell Res. Ther., 8, 151, 10.1186/s13287-017-0600-8 · DOI
  11. Fu, 2012, Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis, Allergy, 67, 1215, 10.1111/j.1398-9995.2012.02875.x. · DOI
  12. Gao, 2017, Effects of mesenchymal stem cells from human induced pluripotent stem cells on differentiation, maturation, and function of dendritic cells, Stem Cell Res. Ther., 8, 48, 10.1186/s13287-017-0499-0 · DOI
  13. Gottlieb, 2003, Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis, Cell Death Differ., 10, 709, 10.1038/sj.cdd.4401231 · DOI
  14. Hammad, 2015, Barrier epithelial cells and the control of type 2 immunity, Immunity, 43, 29, 10.1016/j.immuni.2015.07.007 · DOI · Paper page
  15. He, 2011, Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes, Cardiovasc. Res., 92, 39, 10.1093/cvr/cvr189 · DOI
  16. Jaffer, 2015, Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-beta-mediated collagen production in a murine asthma model, Am. J. Respir. Cell Mol. Biol., 52, 106, 10.1165/rcmb.2013-0519OC · DOI
  17. Jiang, 2016, Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage, Cell Death Dis., 7, e2467, 10.1038/cddis.2016.358 · DOI
  18. Kim, 2014, NLRP3 inflammasome activation by mitochondrial ROS in bronchial epithelial cells is required for allergic inflammation, Cell Death Dis., 5, e1498, 10.1038/cddis.2014.460 · DOI
  19. Lambrecht, 2012, The airway epithelium in asthma, Nat. Med., 18, 684, 10.1038/nm.2737 · DOI
  20. Lambrecht, 2015, The immunology of asthma, Nat. Immunol., 16, 45, 10.1038/ni.3049 · DOI · Paper page
  21. Li, 2014, Mitochondrial transfer of induced pluripotent stem cell-derived mesenchymal stem cells to airway epithelial cells attenuates cigarette smoke-induced damage, Am. J. Respir. Cell Mol. Biol., 51, 455, 10.1165/rcmb.2013-0529OC · DOI
  22. Li, 2018, Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways, J. Allergy Clin. Immunol., 141, 1634, 10.1016/j.jaci.2017.08.017 · DOI
  23. Lian, 2010, Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice, Circulation, 121, 1113, 10.1161/CIRCULATIONAHA.109.898312 · DOI
  24. Liang, 2015, Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction, Cell Death Dis., 6, e1765, 10.1038/cddis.2015.91 · DOI
  25. Lock, 2016, Communication of Ca(2+) signals via tunneling membrane nanotubes is mediated by transmission of inositol trisphosphate through gap junctions, Cell Calcium, 60, 266, 10.1016/j.ceca.2016.06.004 · DOI
  26. Motegi, 2017, Protective effect of mesenchymal stem cells on the pressure ulcer formation by the regulation of oxidative and endoplasmic reticulum stress, Sci. Rep., 7, 17186, 10.1038/s41598-017-17630-5 · DOI
  27. Osswald, 2015, Brain tumour cells interconnect to a functional and resistant network, Nature, 528, 93, 10.1038/nature16071 · DOI
  28. Plotkowski, 2002, Early mitochondrial dysfunction, superoxide anion production, and DNA degradation are associated with non-apoptotic death of human airway epithelial cells induced by Pseudomonas aeruginosa exotoxin A, Am. J. Respir. Cell Mol. Biol., 26, 617, 10.1165/ajrcmb.26.5.4489 · DOI
  29. Poole, 2014, Asthma is a major noncommunicable disease affecting over 230 million people worldwide and represents the most common chronic disease among children, Int. Immunopharmacol., 23, 315, 10.1016/j.intimp.2014.09.013 · DOI
  30. Reddy, 2011, Mitochondrial dysfunction and oxidative stress in asthma: implications for mitochondria-targeted antioxidant therapeutics, Pharmaceuticals (Basel), 4, 429, 10.3390/ph4030429 · DOI
  31. Ribeiro-Rodrigues, 2017, Role of connexin 43 in different forms of intercellular communication - gap junctions, extracellular vesicles and tunnelling nanotubes, J. Cell Sci., 130, 3619, 10.1242/jcs.200667 · DOI
  32. Shen, 2018, Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis, Cell Death Dis., 9, 81, 10.1038/s41419-017-0145-x · DOI
  33. Sinclair, 2016, Characterization of intercellular communication and mitochondrial donation by mesenchymal stromal cells derived from the human lung, Stem Cell Res. Ther., 7, 91, 10.1186/s13287-016-0354-8 · DOI
  34. Spees, 2006, Mitochondrial transfer between cells can rescue aerobic respiration, Proc. Natl. Acad. Sci. U S A, 103, 1283, 10.1073/pnas.0510511103 · DOI
  35. Sun, 2012, Human pluripotent stem cell-derived mesenchymal stem cells prevent allergic airway inflammation in mice, Stem Cells, 30, 2692, 10.1002/stem.1241 · DOI
  36. Sun, 2015, Insensitivity of human iPS cells-derived mesenchymal stem cells to interferon-gamma-induced HLA expression potentiates repair efficiency of hind limb ischemia in immune humanized NOD scid gamma mice, Stem Cells, 33, 3452, 10.1002/stem.2094 · DOI
  37. Takeda, 2018, Mesenchymal stem cells recruit CCR2(+) monocytes to suppress allergic airway inflammation, J. Immunol., 200, 1261, 10.4049/jimmunol.1700562 · DOI
  38. Tilokee, 2016, Paracrine engineering of human explant-derived cardiac stem cells to over-express stromal-cell derived factor 1alpha enhances myocardial repair, Stem Cells, 34, 1826, 10.1002/stem.2373 · DOI
  39. Wang, 2017, The lncRNAs involved in mouse airway allergic inflammation following induced pluripotent stem cell-mesenchymal stem cell treatment, Stem Cell Res. Ther., 8, 2, 10.1186/s13287-016-0456-3 · DOI
  40. Yao, 2015, Connexin 43 upregulation in mouse lungs during ovalbumin-induced asthma, PLoS One, 10, e0144106, 10.1371/journal.pone.0144106 · DOI
  41. Zar, 2012, Challenges in treating pediatric asthma in developing countries, Paediatr. Drugs, 14, 353
  42. Zhang, 2016, iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-alpha yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy, Stem Cell Reports, 7, 749, 10.1016/j.stemcr.2016.08.009 · DOI

Cited by

Sorted by citations

Metadata

Authors
Yao, Y., Fan, X.-L., Jiang, D., Zhang, Y., Li, X., Xu, Z.-B., Fang, S.-B., Chiu, S., Tse, H.-F., Lian, Q., & Fu, Q.-L.
Affiliations
  • The First Affiliated Hospital, Sun Yat-sen University (CN)
  • University of Hong Kong (HK)
  • Guangdong General Hospital (CN)
Corresponding author
  • Lian, Qizhou
  • Fu, Qing-Ling
ORCID
Venue
Stem Cell Reports
Publisher
Elsevier BV
Published
2018-11
Volume
11
Issue
5
Pages
1120-1135
ISSN
2213-6711 (ISSN-L)
DOI
10.1016/j.stemcr.2018.09.012
PMC
PMC6234920
OpenAlex
W2896375235
Cited by
227
References
2
Citations by year
2026: 27 · 2025: 35 · 2024: 28 · 2023: 24 · 2022: 22 · 2021: 37 · 2020: 38 · 2019: 14 · 2018: 2
FWCI
12.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cell Reports (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • NSFC (81322012, 81373174, 81471832, 81671882, 81770984, 31571407)
  • Hong Kong Research Grant Council General Research Fund (HKU17113816, HKU17120517)
  • Science and Technology Foundation of Guangdong Province of China (2015B020225001)
  • Natural Science Foundation of Guangdong Province (2014A030313051, 2016A030308017, 2017A030313105)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords
connexin 43, mitochondrial transfer, iPSC-derived mesenchymal stem cells, asthma inflammation, tunneling nanotubes, epithelial cells, Th2 cytokines, mitochondrial dysfunction, immunomodulation, cell transplantation
MeSH terms
Animals, Asthma, Cell Line, Cobalt, Disease Models, Animal, Epithelial Cells, Humans, Inflammation, Lung, Mitochondria, Ovalbumin, Apoptosis, Connexin 43, Nanotubes, Mesenchymal Stem Cell Transplantation, Mice, Induced Pluripotent Stem Cells, Mesenchymal Stem Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review