Androst-5-ene-3β,7α/β,17β-triols, their plasma levels and dependence on the hypothalamic–pituitary–adrenal axis
Abstract
Androst-5-ene-triols are metabolites of dehydroepiandrosterone, the most abundant steroid hormone in human circulation. Many observations in rodents have demonstrated the anti-inflammatory and immune modulating activity of 7β-hydroxy-androst-5-enes, and on the basis of these experiments androst-5-ene-3β,7β,17β-triol is considered as a potential agent in the treatment of autoimmune diseases. In contrast to the fairly abundant information on the levels and effects of androst-5-ene-triols in experimental animals and of their the pharmacological perspective, little is known about androst-5-ene-3β,7α/β,17β-triols circulating in human blood, their regulation by the hypothalamo-pituitary-adrenal axis, or their daily concentration variability. Here we provide some data on androst-5-ene-3β,7α/β,17β-triol concentrations under various conditions in men and women.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
For Δ5 steroids such as DHEA, 16α-hydroxylation is the most frequent hydroxylation detected in adults, followed by 7α-hydroxylation.
“In terms of Δ5 steroids, e.g. DHEA, 16α-hydroxylation is the most frequent hydroxylation detected in adults followed by 7α-hydroxylation”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [135]
The citation lists haven’t been fetched yet
References 44 · Cited by 4
- Authors
- Stárka, L., Hill, M., Kolatorova, L., & Dušková, M.
- Affiliations
- Institute of Endocrinology (CZ)
- Corresponding author
- Stárka, Luboslav
- Venue
- Steroids
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 134
- Pages
- 88-95
- ISSN
- 0039-128X (ISSN-L)
- OpenAlex
- W2793753083
- Cited by
- 4
- References
- 44
- Citations by year
- 2025: 2 · 2021: 1 · 2019: 1
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Steroids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health of the Czech Republic
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- hypothalamic-pituitary-adrenal axis, plasma steroid levels, sex differences, circadian variation, anti-inflammatory activity, immunomodulation, autoimmune disease therapy
- MeSH terms
- Adult, Androsterone, Female, Humans, Hypothalamus, Male, Pituitary-Adrenal System
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
