A Gate in the Selectivity Filter of Potassium Channels

Bernèche, Simon, Roux, Benoît·2005·Structure

DOI 10.1016/j.str.2004.12.019

Cited by (214)

Items 101–200 of 214

A Trapped Intracellular Cation Modulates K+ Channel Recovery From Slow Inactivation
Evan C. Ray, CAROL J. DEUTSCH · 2006 · The Journal of General Physiology
KAT1 inactivates at sub-millimolar concentrations of external potassium
Brigitte Hertel, Ferenc Horváth, Barnabás Wodala, Annette C. Hurst, Anna Moroni, Gerhard Thiel · 2005 · Journal of Experimental Botany
Direct visualization of electric-field-stimulated ion conduction in a potassium channel
Bo-Ram Lee, K. Ian White, Michael Socolich, Margaret A. Klureza, Robert H. Henning, V. Šrajer, Rama Ranganathan, Doeke R. Hekstra · 2025 · Cell
Argiotoxin in the Closed AMPA Receptor Channel: Experimental and Modeling Study
Oleg I. Barygin, Eugene V. Grishin, Denis B. Tikhonov · 2011 · Biochemistry
IR Spectroscopy Can Reveal the Mechanism of K+ Transport in Ion Channels
Steven E. Strong, Nicholas J. Hestand, Alexei A. Kananenka, Martin T. Zanni, James L. Skinner · 2019 · Biophysical Journal
Interaction of d-Tubocurarine with Potassium Channels: Molecular Modeling and Ligand Binding
Alexey V. Rossokhin, Georgeta Teodorescu, Stephan Grissmer, Boris S. Zhorov · 2006 · Molecular Pharmacology
Ion Binding to KcsA: Implications in Ion Selectivity and Channel Gating
Maria Lourdes Renart, I. Triano, José Antonio Poveda, José Antonio Encinar, Asia M. Fernández-Carvajal, Antonio Vicente Ferrer-Montiel, Javier Gómez, José Manuel González-Ros · 2010 · Biochemistry
Ion binding in the Open HCN Pacemaker Channel Pore: Fast Mechanisms to Shape “Slow” Channels
Alex K. Lyashchenko, Gareth R. Tibbs · 2008 · The Journal of General Physiology
Conduction and Gating Properties of the TRAAK Channel from Molecular Dynamics Simulations with Different Force Fields
Riccardo Ocello, Simone Furini, Francesca Lugli, Maurizio Recanatini, Cármen Domene, Matteo Masetti · 2020 · Journal of Chemical Information and Modeling
Differential binding of monovalent cations to KcsA: Deciphering the mechanisms of potassium channel selectivity
Estefanía Montoya, Maria Lourdes Renart, Ana Marcela Giudici, José Antonio Poveda, Asia M. Fernández-Carvajal, Andrés Morales, José Manuel González-Ros · 2017 · Biochimica et Biophysica Acta (BBA) - Biomembranes
Kir4.1 K+channels are regulated by external cations
Johan M. Edvinsson, Anish J. Shah, Lawrence G. Palmer · 2011 · Channels
Slow Inactivation inShakerK Channels Is Delayed by Intracellular Tetraethylammonium
Vivian M. Gonzalez-Perez, Alan Neely, Christian Tapia, Giovanni González-Gutiérrez, Gustavo Contreras, Patricio Orio, Verónica L. Lagos, Guillermo Larrazábal Rojas, Tania Estévez, Katherine Stack et al. · 2008 · The Journal of General Physiology
Examining Ion Channel Properties Using Free-Energy Methods
Cármen Domene, Simone Furini · 2009 · Methods in enzymology on CD-ROM/Methods in enzymology
K2P Potassium Channels, Mysterious and Paradoxically Exciting
Steve A. N. Goldstein · 2011 · Science Signaling
Ion binding properties and structure stability of the NaK channel
Rong Shen, Wanlin Guo · 2009 · Biochimica et Biophysica Acta (BBA) - Biomembranes
Charybdotoxin and Margatoxin Acting on the Human Voltage-Gated Potassium Channel hKv1.3 and Its H399N Mutant: An Experimental and Computational Comparison
Azadeh Nikouee, Morteza Khabiri, Stephan Grissmer, Rudiger H. Ettrich · 2012 · The Journal of Physical Chemistry B
An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels
Christopher A. Ahern, Amy L. Eastwood, Dennis A. Dougherty, Richard Horn · 2009 · The Journal of General Physiology
Gramicidin Channels Are Internally Gated
Tyson L. Jones, Riqiang Fu, Frederick Nielson, Timothy A. Cross, David D. Busath · 2010 · Biophysical Journal
High-Risk Long QT Syndrome Mutations in the Kv7.1 (KCNQ1) Pore Disrupt the Molecular Basis for Rapid K+ Permeation
Don E. Burgess, Daniel C. Bartos, Allison R. Reloj, Kenneth S. Campbell, Jonathan N. Johnson, David J. Tester, Michael John Ackerman, Véronique Fressart, Isabelle Denjoy, Pascale Guicheney et al. · 2012 · Biochemistry
The influence of membrane bilayer thickness on KcsA channel activity
Karen M. Callahan, Benoit Mondou, Louis J. Sasseville, J. L. Schwartz, Nazzareno D’Avanzo · 2019 · Channels
Block of CaV1.2 Channels by Gd3+ Reveals Preopening Transitions in the Selectivity Filter
Olga Babich, John Reeves, Roman E. Shirokov · 2007 · The Journal of General Physiology
Absence of Ion-Binding Affinity in the Putatively Inactivated Low-[K+] Structure of the KcsA Potassium Channel
Céline Boiteux, Simon Bernèche · 2011 · Structure
Energetics of Double-Ion Occupancy in the Gramicidin A Channel
Yuhui Li, Olaf Sparre Andersen, Benoı̂t Roux · 2010 · The Journal of Physical Chemistry B
Exploring the Viral Channel KcvPBCV-1 Function via Computation
Alma Andersson, Marina A. Kasimova, Lucie Delemotte · 2018 · The Journal of Membrane Biology
Non-equivalent role of TM2 gating hinges in heteromeric Kir4.1/Kir5.1 potassium channels
Lijun Shang, Stephen J. Tucker · 2007 · European Biophysics Journal
Computer Simulations of Voltage-Gated Cation Channels
Werner L. Treptow, Michael Lawrence Klein · 2012 · The Journal of Physical Chemistry Letters
Contribution of Ion Binding Affinity to Ion Selectivity and Permeation in KcsA, a Model Potassium Channel
Maria Lourdes Renart, Estefanía Montoya, Asia M. Fernández-Carvajal, Maria Luisa Molina, José Antonio Poveda, José Antonio Encinar, José L. Ayala, Antonio Vicente Ferrer-Montiel, Javier Gómez, Andrés Morales et al. · 2012 · Biochemistry
Insight into the origins of the barrier-less knock-on conduction in the KcsA channel: molecular dynamics simulations and ab initio calculations
Sebastian Kraszewski, Céline Boiteux, Marek Langner, Christophe Ramseyer · 2007 · Physical Chemistry Chemical Physics
A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics
Jason G. McCoy, Radda Rusinova, Dorothy M. Kim, Julia Kowal, Sourabh Banerjee, Alexis Jaramillo Cartagena, Ameer N. Thompson, Ludmila Kolmakova-Partensky, Henning Stahlberg, Olaf Sparre Andersen et al. · 2014 · Journal of Biological Chemistry
Four-mode gating model of fast inactivation of sodium channel Nav1.2a
Tobias Huth, Johann Schmidtmayer, Christian Alzheimer, Ulf‐Peter Hansen · 2008 · Pflügers Archiv - European Journal of Physiology
Tl+-induced μs Gating of Current Indicates Instability of the MaxiK Selectivity Filter as Caused by Ion/Pore Interaction
Indra Schroeder, Ulf‐Peter Hansen · 2008 · The Journal of General Physiology
Combining enhanced sampling with experiment-directed simulation of the GYG peptide
Dilnoza B. Amirkulova, Andrew D. White · 2018 · Journal of Theoretical and Computational Chemistry
Structural Insights and Influence of Terahertz Waves in Midinfrared Region on Kv1.2 Channel Selectivity Filter
Xiaofei Zhao, Wen Jiang Ding, Hongguang Wang, Yize Wang, Yanjiang Liu, Yongdong Li, Chunliang Liu · 2024 · ACS Omega
A Disease Mutation Causing Episodic Ataxia Type I in the S1 Links Directly to the Voltage Sensor and the Selectivity Filter in Kv Channels
Dimitri Petitjean, Tanja Kalstrup, Juan Zhao, Rikard Blunck · 2015 · Journal of Neuroscience
Multiple mechanisms underlying rectification in retinal cyclic nucleotide-gated (CNGA1) channels
Manuel Arcangeletti, Arin S. Marchesi, Monica Mazzolini, Vincent Torre · 2013 · Physiological Reports
Interference of Shot Noise of Open-Channel Current with Analysis of Fast Gating: Patchers do not (Yet) Have to Care
Indra Schroeder, Ulf‐Peter Hansen · 2009 · The Journal of Membrane Biology
Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel
Maria Lourdes Renart, Estefanía Montoya, Ana Marcela Giudici, José Antonio Poveda, Asia M. Fernández-Carvajal, Andrés Morales, José Manuel González-Ros · 2017 · Journal of Biological Chemistry
The pore domain in glutamate-gated ion channels: Structure, drug binding and similarity with potassium channels
Denis B. Tikhonov, Boris S. Zhorov · 2020 · Biochimica et Biophysica Acta (BBA) - Biomembranes
Quantum Mechanical Coherence of K+ Ion Wave Packets Increases Conduction in the KcsA Ion Channel
Johann Summhammer, Georg Sulyok, Gustav Bernroider · 2020 · Applied Sciences
Molecular dynamics simulations of potassium channels
Cármen Domene · 2007 · Open Chemistry
Ion Selectivity in the ENaC/DEG Family: A Systematic Review with Supporting Analysis
Cédric Vallée, Brendan J. Howlin, Rebecca Lewis · 2021 · International Journal of Molecular Sciences
Stabilization of the Conductive Conformation of a Voltage-gated K+ (Kv) Channel
Jose S. Santos, Ruhma Syeda, Mauricio Montal · 2013 · Journal of Biological Chemistry
P-Loop Residues Critical for Selectivity in K+ Channels Fail to Confer Selectivity to Rabbit HCN4 Channels
Nazzareno D’Avanzo, Roman Pekhletski, Peter H. Backx · 2009 · PLoS ONE
An NMR investigation of the structure, function and role of the hERG channel selectivity filter in the long QT syndrome
Andrée E. Gravel, Alexandre A. Arnold, Érick J. Dufourc, Isabelle Marcotte · 2013 · Biochimica et Biophysica Acta (BBA) - Biomembranes
Permeating disciplines: Overcoming barriers between molecular simulations and classical structure-function approaches in biological ion transport
Rebecca J. Howard, Vincenzo Carnevale, Lucie Delemotte, Ute A. Hellmich, Brad S. Rothberg · 2017 · Biochimica et Biophysica Acta (BBA) - Biomembranes
Potassium‐dependent activation of Kir4.2 K+ channels
Johan M. Edvinsson, Anish J. Shah, Lawrence G. Palmer · 2011 · The Journal of Physiology
The Distal C-Terminal Region of the KcsA Potassium Channel Is a pH-Dependent Tetramerization Domain
Guy Kamnesky, Hadassa Shaked, Jordan H. Chill · 2012 · Journal of Molecular Biology
Using a five-state model for fitting amplitude histograms from MaxiK channels: β-distributions reveal more than expected
Indra Schroeder, Ulf‐Peter Hansen · 2009 · European Biophysics Journal
A Double‐Point Mutation in the Selectivity Filter Site of the KCNQ1 Potassium Channel Results in a Severe Phenotype, LQT1, of Long QT Syndrome
Taruna Ikrar, Haruo Hanawa, Hiroshi Watanabe, SHINSUKE OKADA, Yoshiyasu Aizawa, Mahmoud Mohammed Ramadan, Satoru Komura, FUMIO YAMASHITA, Masaomi Chinushi, Yoshifusa Aizawa · 2008 · Journal of Cardiovascular Electrophysiology
A novel mutation KCNQ1p.Thr312del is responsible for long QT syndrome type 1
Xiao‐Meng Chen, Kai Guo, Hong Li, Qiu‐Fen Lu, Chao Yang, Ying Yu, Jianwen Hou, Yudong Fei, Jian Sun, Jun Wang et al. · 2018 · Heart and Vessels
Tuning the tetraethylammonium sensitivity of potassium channel Kcv by subunit combination
Qiulin Tan, Brandon Ritzo, Kai Tian, Li‐Qun Gu · 2012 · The Journal of General Physiology
Modelling the pH-dependent Properties of Kv1 Potassium Channels
Binbin Liu, David R. Westhead, Mark R. Boyett, Jim Warwicker · 2007 · Journal of Molecular Biology
Investigation of a KcsA Cytoplasmic pH Gate in Lipoprotein Nanodiscs
Arwa Qasim, Inbal Sher, Orel Hirschhorn, Hadassa Shaked, Zena Qasem, Sharon Ruthstein, Jordan H. Chill · 2018 · ChemBioChem
Intrinsic Free Energy of the Conformational Transition of the KcsA Signature Peptide from Conducting to Nonconducting State
Ilja V. Khavrutskii, Mikolai Fajer, James Andrew McCammon · 2008 · Journal of Chemical Theory and Computation
Base of pore loop is important for rectification, activation, permeation, and block of Kir3.1/Kir3.4.
Samy M. Y. Makary, T. Claydon, K. Dibb, M. Boyett · 2006 · Biophysical Journal
A Deep Learning Approach to Uncover Voltage-Gated Ion Channels’ Intermediate States
Julia Kacher, Olga S. Sokolova, Mounir Tarek · 2024 · The Journal of Physical Chemistry B
TOK channels use the two gates in classical K + channels to achieve outward rectification
Anthony Lewis, Zoe A. McCrossan, Rían W. Manville, M. Oana Popa, Luis G. Cuello, Steve A. N. Goldstein · 2020 · The FASEB Journal
Molecular determinants of tetramerization in the KcsA cytoplasmic domain
Guy Kamnesky, Orel Hirschhorn, Hadassa Shaked, Jingfei Chen, Lishan Yao, Jordan H. Chill · 2014 · Protein Science
Quantum entanglement in the voltage dependent sodium channel can reproduce the salient features of neuronal action potential initiation
Johann Summhammer, Gustav Bernroider · 2007 · arXiv (Cornell University)
Molecular Determinants of Gating at the Potassium Channel Selectivity Filter
Julio F. Cordero-Morales · 2008
A gate mechanism indicated in the selectivity filter of the potassium channel KscA
Juraj Kóňa, M. Minozzi, Vincent Torre, Paolo Carloni · 2007 · Theoretical Chemistry Accounts
Unraveling of a Strongly Correlated Dynamical Network of Residues Controlling the Permeation of Potassium in KcsA Ion Channel
Salvatore M. Cosseddu, Eunju Julia Choe, Igor A. Khovanov · 2021 · Entropy
Epithelial Na+ Channels
Shaohu Sheng, Ossama B. Kashlan, Kenneth R. Hallows, Thomas R. Kleyman · 2012 · Elsevier eBooks
Kir5.1 underlies long-lived subconductance levels in heteromeric Kir4.1/Kir5.1 channels from Xenopus tropicalis
Lijun Shang, Sarah V. Ranson, Stephen J. Tucker · 2009 · Biochemical and Biophysical Research Communications
Renal Ion Channels, Electrophysiology of Transport, and Channelopathies
James D. Stockand · 2012 · Elsevier eBooks
Constitutive sodium permeability in a Caenorhabditis elegans two-pore domain potassium channel
Olga Andrini, Ismail Ben Soussia, Philippe Tardy, Denise S. Walker, Carlos Peña-Varas, David Ramírez, Marie Gendrel, Marine Mercier, Sonia El Mouridi, Alice Leclercq-Blondel et al. · 2024 · Proceedings of the National Academy of Sciences
And Yet It Moves: Conformational States of the Ca2+ Channel Pore
Riccardo Olcese · 2007 · The Journal of General Physiology
A Twist on Potassium Channel Gating
Wei Zhou, Lily Yeh Jan · 2010 · Cell
Potassium channel gating: Not an open and shut case
Raymond S. Norton, Jacqueline M. Gulbis · 2010 · Proceedings of the National Academy of Sciences
Evaluation of channel function after alteration of amino acid residues at the pore center of KCNQ1 channel
Taruna Ikrar, Haruo Hanawa, Hiroshi Watanabe, Yoshiyasu Aizawa, Mahmoud Mohammed Ramadan, Masaomi Chinushi, Minoru Horie, Yoshifusa Aizawa · 2008 · Biochemical and Biophysical Research Communications
Separation of heteromeric potassium channel Kcv towards probing subunit composition‐regulated ion permeation and gating
Qiulin Tan, Jiwook Shim, Li‐Qun Gu · 2010 · FEBS Letters
Do selectivity filter carbonyls in K+ channels flip away from the pore? Two-dimensional infrared spectroscopy study
Nikhil Maroli, Matthew J. Ryan, Martin T. Zanni, Alexei A. Kananenka · 2024 · Journal of Structural Biology X
Kir2.2 p.Thr140Met: a genetic susceptibility to sporadic periodic paralysis.
Chunxiang Fan, Marius Kuhn, Alexander Pepler, James R. Groome, Vern D. Winston, Saskia Biskup, Frank Lehmann‐Horn, Karin Jurkat‐Rott · 2018 · Europe PMC (PubMed Central)
Molecular Dynamics Simulation Approaches to K Channels
Alessandro Grottesi, Shozeb M Haider, Mark S.P. Sansom · 2007 · Springer eBooks
Primary Aldosteronism: Small Molecule Antagonists of Mutant KCNJ5 Potassium Channels
Sanas Mir-Bashiri, Martina Tetti, Dennis Fröbel, Yingxian Pang, Yuhong Yang, Dunja Reiss, Jonas Bibus, Mirko Peitzsch, Graeme Eisenhofer, Nicole Bechmann et al. · 2025 · Hypertension
Two-dimensional infrared (2D IR) spectroscopy for elucidating ion occupancies in the selectivity filter of ion channels1
Huong T. Kratochvil, Martin T. Zanni · 2018 · Biomedical Spectroscopy and Imaging
Insights into the Conformational Dynamics of Potassium Channels Using Homo-FRET Approaches
Ana Coutinho, Clara Díaz-García, Ana Marcela Giudici, Maria Lourdes Renart · 2022 · Springer series on fluorescence
Steady-state and time-resolved fluorescent methodologies to characterize the conformational landscape of the selectivity filter of K+ channels
Maria Lourdes Renart, Ana Marcela Giudici, José Manuel González-Ros, José Antonio Poveda · 2024 · Methods
Mechanism of selectivity filter constriction in potassium channel: Insights from high-throughput steered molecular dynamics simulations
Wenyu Zhong · 2024 · Biochemical and Biophysical Research Communications
NEURAL TRANSITION DYNAMICS AND CONSCIOUS PERCEPTIVE STATES
Gustav Bernroider · 2016 · WORLD SCIENTIFIC eBooks
Computer Simulations of Membrane Proteins
Christian Jorgensen, Victoria Oakes, Cármen Domene · 2017 · Springer series in biophysics
Diacylglycerol Signaling Pathway Modulates Membrane Potentials in Red Blood Cells
Alagu P. Thiruvengadam · 2021 · International Journal of Psychiatry Research
Voltage-Gated Potassium Channels
Stephen J. Korn, Josef G. Trapani · 2007 · Springer eBooks
Movement of Potassium Ions inside KcsA in the High Concentration Regime using a Molecular Dynamics Simulation
Myojeong Kim, Byeong Cheol Jo, Hyun Jung Yoon, Sangwook Wu, Jayaraman Thangappan, Changsun Eun · 2018 · Journal of the Korean Physical Society
The Optimized Conformation Dynamics of the KcsA Filter as a Probe for Lateral Membrane Effects: A First Principle Based Femto-Sec Resolution MD Study
Johann Summhammer, Georg Sulyok, Gustav Bernroider, Massimo Cocchi · 2022 · Membranes
Role of DAG Signaling Pathway in Bipolar Disorder
Alagu Thiruvengadam · 2023 · Neurology - Research & Surgery
Self-referential processing as the biological switch between classical and quantum functioning of the brain
Josh Roeloffs, Jack A. Tuszyński · 2026 · Frontiers in Human Neuroscience
Epithelial Na+ Channels
Shaohu Sheng, John P. Johnson, Thomas R. Kleyman · 2008 · Elsevier eBooks
Introduction to Atomistic Modeling and Simulation of Biomolecular Systems
Slava Bekker, Yanxiao Han, Igor V. Vorobyov · 2024 · Springer eBooks
The TEMPO integrator: accelerating molecular simulations by temporally multiscale force prediction
Reshef Mintz, Barak Raveh · 2024 · Bioinformatics Advances
Single-channel fast-flicker currents deciphered for kinetic model topology and rates
Shigetoshi Oiki · 2025 · Cell Reports Physical Science
Modeling and Simulation of Ion Channels
Simon Bernèche, Beno�t Roux · 2008 · WORLD SCIENTIFIC eBooks
Three-dimensional protein structure determination by high-resolution solid-state NMR spectroscopy
Adam Lange · 2006
Ion Channel Activity of Pentameric Phospholamban
Serena Smeazzetto, Michael Henkel, Tommaso Ferri, Gerhard Thiel, Maria Rosa Moncelli · 2010 · Biophysical Journal
Crystalline, membrane-embedded, and fibrillar proteins investigated by solid-state NMR spectroscopy
Schneider, Robert · 2009 · eDiss (Georg-August-Universität Göttingen)
Structural Basis for Rapid Voltage Dependent Inactivation of HERG Potassium Channels
Jamie I. Vandenberg, Carus H. Y. Lau, Emelie Flood, Mark J. Hunter, Chai‐Ann Ng, James C. Bouwer, Alastair G. Stewart, Eduardo Perozo, Toby W. Allen · 2021 · Research Square
Constitutive sodium permeability in a C. elegans two-pore domain potassium channel
Olga Andrini, Ismail Ben Soussia, Philippe Tardy, Denise S. Walker, Carlos Peña-Varas, David Ramírez, Marie Gendrel, Marine Mercier, Sonia El Mouridi, Alice Leclercq-Blondel et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Will the Real Single HCN Channel Please Stand Up?
Edgar C. Young · 2013 · Biophysical Journal
Mechanisms of action of ligands of potential-dependent sodium channels
Denis B. Tikhonov · 2008 · Neuroscience and Behavioral Physiology
Indications for quantum computation requirements from comparative brain analysis
Gustav Bernroider, Wolfgang Baer · 2010 · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE