The crystal structure of PCSK9: A regulator of plasma LDL-cholesterol

Piper, Derek E.; Jackson, Simon; Liu, Qiang; Romanow, William G.; Shetterly, Susan; Thibault, Stephen T.; Shan, Bei; Walker, Nigel P.C.

doi:10.1016/j.str.2007.04.004

The crystal structure of PCSK9: A regulator of plasma LDL-cholesterol

Proprotein convertase subtilisin kexin type 9 (PCSK9) has been shown to be involved in the regulation of extracellular levels of the low-density lipoprotien receptor (LDLR). Although PCSK9 is a subtilase, it has not been shown to degrade the LDLR, and its LDLR-lowering mechanism remains uncertain…