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Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes

Fritsche, Ellen, Grandjean, Philippe, Crofton, Kevin M., Aschner, Michael, Goldberg, Alan, Heinonen, Tuula, Hessel, Ellen V.S., Hogberg, Helena T. +15 more·2018·Toxicology and Applied Pharmacology
DOI 10.1016/j.taap.2018.02.004PMC PMC6097873
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  • The DNT in vitro Battery (DNT-IVB) is a suite of 17 cell-based assays targeting key neurodevelopmental processes and is nearing regulatory implementation for chemical risk assessment.

    “The DNT in vitro Battery (DNT-IVB), a suite of 17 cell-based assays targeting these key processes, is nearing regulatory implementation for chemical risk assessment (Bal-Price et al., 2018b; Fritsche et al., 2018; Masjosthusmann et al., 2020; EFSA, 2021; Sachana et al., 2021a; Sachana et al., 2021b; Carstens et al., 2022; Blum et al., 2023; OECD, 2023; Smirnova et al., 2024).”

    From Challenges and solutions in transitioning to animal-free standards: a comprehensive analysis of components in human cell-based developmental neurotoxicity assays (2026) · cites this paper as Fritsche et al., 2018

    The Abstract supports using in vitro tests of key neurodevelopmental processes for chemical assessment and describes ongoing efforts toward regulatory acceptance. It does not identify a DNT-IVB comprising 17 cell-based assays or say that this specific battery is nearing implementation; it calls for criteria to determine the readiness of available methods. No page number is provided in our copy. (LLM, conf=0.86)

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Research works printed but not linked: 48

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Authors
Fritsche, E., Grandjean, P., Crofton, K. M., Aschner, M., Goldberg, A., Heinonen, T., Hessel, E. V. S., Hogberg, H. T., Bennekou, S. H., Lein, P. J., Leist, M., Mundy, W. R., Paparella, M., Piersma, A. H., Sachana, M., Schmuck, G., Solecki, R., Terron, A., Monnet-Tschudi, F., Wilks, M. F., Witters, H., Zurich, M.-G., & Bal-Price, A.
ORCID
Grandjean, Philippe
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2018-09
Volume
354
Pages
3-6
ISSN
0041-008X
DOI
10.1016/j.taap.2018.02.004
PMC
PMC6097873
Cited by
118
References
2
Language
en
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