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Cited by 71Occupational and environmental lung diseasesOccupational Health and Global JusticeOccupational Health and Safety in Workplaces

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A comparison of asbestos fiber potency and elongate mineral particle (EMP) potency for mesothelioma in humans

Garabrant, David H., Pastula, Susan T.·2018·Toxicology and Applied Pharmacology
DOI 10.1016/j.taap.2018.07.003
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Abstract

We analyzed the mesothelioma mortality in cohorts of workers exposed to crocidolite, amosite, and chrysotile to estimate asbestos fiber potency for mesothelioma, using the method of Hodgson and Darnton (2000). We relied on the original 17 cohort studies in their analysis, along with 3 updates of those studies and 3 new asbestos cohort studies published since 2000. We extended the analyses to examine the mesothelioma potency of tremolite in vermiculite from Libby, Montana, and for non-asbestiform elongate mineral particles (EMPs) in taconite iron ore, talc, and South Dakota gold mining. Mesothelioma potency (R Meso ) was calculated as the percent of all expected deaths that were due to mesothelioma per fiber/cc-year of exposure.The R Meso was 0.0012 for chrysotile, 0.099 for amosite, and 0.451 for crocidolite: thus, the relative potency of chrysotile:amosite:crocidolite was 1:83:376, which was not appreciably different from the estimates by Hodgson and Darnton in 2000. The R Meso for taconite mining fibers was 0.069 which was slightly smaller than that for amosite. The R Meso for Libby fibers was 0.028 which was greater than that for chrysotile and less than that for amosite. Talc and gold mining EMPs were non-potent for mesothelioma. Although there are a number of methods for estimating fiber potency of asbestos and non-asbestiform EMPs, the method of Hodgson and Darnton provides a uniform method by which fiber potency can be compared across many fiber types. Our estimates of…

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Metadata

Authors
Garabrant, D. H., & Pastula, S. T.
Corresponding author
Garabrant, David H.
ORCID
Venue
Toxicology and Applied Pharmacology
Publisher
Elsevier BV
Published
2018-12
Volume
361
Pages
127-136
ISSN
0041-008X (ISSN-L)
DOI
10.1016/j.taap.2018.07.003
OpenAlex
W2887671022
Cited by
71
References
0
Citations by year
2026: 3 · 2025: 10 · 2024: 12 · 2023: 11 · 2022: 9 · 2021: 8 · 2020: 11 · 2019: 6
FWCI
4.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Toxicology and Applied Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
  • Social Sciences › Health › Occupational Health and Global Justice
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational Health and Safety in Workplaces
Keywords
mesothelioma, crocidolite, amosite, chrysotile, tremolite, talc, gold mining, occupational exposure, mesothelioma mortality, relative potency
MeSH terms
Air Pollutants, Occupational, Aluminum Silicates, Asbestos, Carcinogens, Humans, Iron, Lung Neoplasms, Mesothelioma, Minerals, Mining, Particle Size, Talc, Cohort Studies, Occupational Exposure, Asbestos, Serpentine, Asbestos, Amphibole, Asbestos, Crocidolite, Asbestos, Amosite, Silicates, Particulate Matter

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Garabrant, D. H., & Pastula, S. T. (2018). A comparison of asbestos fiber potency and elongate mineral particle (EMP) potency for mesothelioma in humans. Toxicology and Applied Pharmacology. https://doi.org/10.1016/j.taap.2018.07.003