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Cited by 434

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Ketamine – More mechanisms of action than just NMDA blockade

Open access
Sleigh, Jamie, Harvey, Martyn, Voss, Logan, Denny, Bill·2014·Trends in Anaesthesia and Critical Care
DOI 10.1016/j.tacc.2014.03.002
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Abstract

Ketamine has been in clinical use for over half a century, yet its precise mechanisms of action remain mysterious for the large part. Its hypnotic effects appear to be largely mediated by blockade of NMDA and HCN1 receptors, but cholinergic, aminergic, and opioid systems appear to play both a positive and negative modulatory role in both sedation and analgesia. Ketamine's effects in chronic pain, and as an antidepressant, far outlast the actual drug levels, and are probably mediated by a secondary increase in structural synaptic connectivity that is mediated by a neuronal response to the ketamine-induced hyper-glutamatergic state.

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Metadata

Authors
Sleigh, J., Harvey, M., Voss, L., & Denny, B.
Venue
Trends in Anaesthesia and Critical Care
Publisher
Elsevier BV
Published
2014-06
Volume
4
Issue
2-3
Pages
76-81
ISSN
2210-8440 (ISSN-L)
DOI
10.1016/j.tacc.2014.03.002
OpenAlex
W2156342513
Cited by
434
References
57
FWCI
22.00
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Ketamine – More mechanisms of action than just NMDA blockade. https://app.cochat.ai/papers/10.1016/j.tacc.2014.03.002
The paper
Sleigh, J., Harvey, M., Voss, L., & Denny, B. (2014). Ketamine – More mechanisms of action than just NMDA blockade. Trends in Anaesthesia and Critical Care. https://doi.org/10.1016/j.tacc.2014.03.002

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.