New strategies to analyze argentatins A and B in guayule (Parthenium argentatum, A. Gray)
Abstract
There is considerable interest in the exploitation of compounds belonging to the triterpenoid family from guayule (Parthenium argentatum, A. Gray), as they offer several beneficial effects to human health. The most abundant triterpenoids in guayule resin are the argentatins, which are currently analyzed by labor-intensive and time-consuming techniques. The purpose of the present study was to estimate argentatins and isoargentatins A and B in guayule using near-infrared spectroscopy (NIRS) and flow injection analysis (FIA). Results revealed that the best partial least squares regression model exhibited excellent correlation with the values estimated by NIRS calibration (r 2 c = 0.99-1.00) and cross-validation (r 2 cv = 0.94-0.99), and the residual predictive deviation was >3 in all cases. After optimization of the liquid chromatography-mass spectrometry and FIA parameters, the FIA mode could reliably collect data for argentatin A and B after applying a calculated coverage factor. In sum, NIRS and FIA appear to be a robust option for the estimation and routine analysis of argentatins in guayule stems and resin, respectively.
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The isolated argentatins were analysed by HPLC and LC-mass spectrometry and compared against standards.
“The isolated compounds were analysed by HPLC coupled to a refractive index detector and by LC‐mass spectrometry, as described [23, 24], and were compared against standards”
From Synergistic Potential of Argentatins A and B to Improve 5‐Fluorouracil Cytotoxicity in Colorectal Cancer Cell Models (2024) · cites this paper as [24]
Cites
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Argentatin B Inhibits Proliferation of Prostate and Colon Cancer Cells by Inducing Cell Senescence
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Sánchez‐Olivares, P., Silva‐Nolasco, A. M., de la Cruz‐Morcillo, M. A., García‐Martínez, M. M., Pinedo‐Serrano, A., Carmona, M., & Galán‐Moya, E. M. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70294 · Cited by 5 · see citing works
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- Authors
- Gallego, B., García-Martínez, M. M., Latorre, G., Carrión, M. E., Hurtado de Mendoza, J., Carmona, M., & Zalacain, A.
- Affiliations
- Hospital Central de la Defensa Gómez Ulla (ES)
- Instituto Tecnico Agronómico Provincial (ES)
- University of Castilla-La Mancha (ES)
- ORCID
- Venue
- Talanta
- Publisher
- Elsevier BV
- Published
- 2023-12
- Volume
- 265
- Pages
- 124856
- ISSN
- 0039-9140 (ISSN-L)
- OpenAlex
- W4381331353
- Cited by
- 4
- References
- 6
- Citations by year
- 2026: 2 · 2024: 2
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Talanta (publishedVersion)
- PubMed (publishedVersion)
- RUIdeRA - Institutional University Repository (University of Castilla-La Mancha) (submittedVersion)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Keywords
- guayule, Parthenium argentatum, triterpenoids, near-infrared spectroscopy, flow injection analysis, partial least squares regression, guayule resin, natural product quantification
- MeSH terms
- Triterpenes, Asteraceae
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