Two-way traffic on the road to plasma membrane repair
Open accessAbstract
Ca(2+) influx through plasma membrane wounds triggers a rapid-repair response that is essential for cell survival. Earlier studies showed that repair requires the exocytosis of intracellular vesicles. Exocytosis was thought to promote resealing by 'patching' the plasma membrane lesion or by facilitating bilayer restoration through reduction in membrane tension. However, cells also rapidly repair lesions created by pore-forming proteins, a form of injury that cannot be resealed solely by exocytosis. Recent studies indicate that, in cells injured by pores or mechanical abrasions, exocytosis is followed by lesion removal through endocytosis. Describing the relationship between wound-induced exocytosis and endocytosis has implications for the understanding of muscular degenerative diseases that are associated with defects in plasma membrane repair.
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Fusion of lysosomes with the plasma membrane is a calcium-dependent process crucial for membrane repair, limiting pathogen entry, and clearing cellular debris.
“Fusion of lysosomes with the plasma membrane is a calcium-dependent process crucial for membrane repair, limiting pathogen entry, and clearing cellular debris (Idone et al., 2008).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Idone et al., 2008
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References 76 · Cited by 138
- Authors
- Idone, V., Tam, C., & Andrews, N. W.
- Affiliations
- Yale University (US)
- Corresponding author
- Andrews, Norma W.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 18
- Issue
- 11
- Pages
- 552-559
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC2593466
- OpenAlex
- W2093327342
- Cited by
- 138
- References
- 76
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 12 · 2016: 8 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 12
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM064625)
- National Institute of Allergy and Infectious Diseases (F32AI069785, R37AI034867)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- plasma membrane repair, calcium influx, exocytosis, endocytosis, pore-forming proteins, membrane tension, membrane resealing, calcium signaling
- MeSH terms
- Animals, Calcium, Cell Membrane, Clathrin, Endocytosis, Exocytosis, HeLa Cells, Humans, Kidney, Calcium Signaling, Caveolae
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