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Cited by 139Cholesterol and Lipid MetabolismLipid Membrane Structure and BehaviorCancer, Lipids, and Metabolism

Cell cholesterol homeostasis: Mediation by active cholesterol

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Steck, Theodore L., Lange, Yvonne·2010·Trends in Cell Biology
DOI 10.1016/j.tcb.2010.08.007PMC PMC2967630
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Abstract

Recent evidence suggests that the major pathways mediating cell cholesterol homeostasis respond to a common signal: active membrane cholesterol. Active cholesterol is the fraction that exceeds the complexing capacity of the polar bilayer lipids. Increments in plasma membrane cholesterol exceeding this threshold have an elevated chemical activity (escape tendency) and redistribute via diverse transport proteins to both circulating plasma lipoproteins and intracellular organelles. Active cholesterol thereby prompts several feedback responses. It is the substrate for its own esterification and for the synthesis of regulatory side-chain oxysterols. It also stimulates manifold pathways that down-regulate the biosynthesis, curtail the ingestion and increase the export of cholesterol. Thus, the abundance of cell cholesterol is tightly coupled to that of its polar lipid partners through active cholesterol.

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  • ABCA1 is the main cholesterol efflux transporter in astrocytes and transfers cellular cholesterol and phospholipids onto lipid-poor apolipoproteins.

    “The main cholesterol efflux transporter in astrocytes is ATP-binding cassette transporter A1 (ABCA1), which transfers cellular cholesterol and PLs onto lipid-poor apolipoproteins that shuttle cholesterol8–10.”

    From An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis (2023) · cites this paper as [9]

    The “Reverse cholesterol transport” section says ABCA1 appears to transfer cholesterol and phospholipids to lipid-poor apolipoprotein A-I. It does not identify ABCA1 as the main cholesterol efflux transporter in astrocytes or discuss astrocytes in this context; no page number is available in our copy. (LLM, conf=0.87)

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Authors
Steck, T. L., & Lange, Y.
Affiliations
  • University of Chicago (US)
  • Rush University Medical Center (US)
Corresponding author
Steck, Theodore L.
ORCID
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2010-11
Volume
20
Issue
11
Pages
680-687
ISSN
0962-8924 (ISSN-L)
DOI
10.1016/j.tcb.2010.08.007
PMC
PMC2967630
OpenAlex
W2025869401
Cited by
139
References
1
Citations by year
2026: 4 · 2025: 3 · 2024: 9 · 2023: 17 · 2022: 9 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 3 · 2017: 11 · 2016: 6 · 2015: 11 · 2014: 9 · 2013: 13 · 2012: 13
FWCI
1.82
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (HL-28448, R01HL028448)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
membrane cholesterol, cholesterol esterification, cholesterol biosynthesis, cholesterol transport, serum lipoproteins, cholesterol export, feedback regulation
MeSH terms
Animals, Cell Membrane, Cholesterol, Homeostasis, Humans, Intracellular Membranes, Phospholipids, Organelles, Fatty Acid-Binding Proteins

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