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Cited by 137Genomics and Chromatin DynamicsChromatin Remodeling and CancerNuclear Structure and Function

Mechanisms of nuclear actin in chromatin-remodeling complexes

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Kapoor, Prabodh, Shen, Xuetong·2014·Trends in Cell Biology
DOI 10.1016/j.tcb.2013.10.007PMC PMC3995414
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Abstract

The mystery of nuclear actin has puzzled biologists for decades largely due to the lack of defined experimental systems. However, the development of actin-containing chromatin-modifying complexes as a defined genetic and biochemical system in the past decade has provided an unprecedented opportunity to dissect the mechanism of actin in the nucleus. Although the established functions of actin mostly rely on its dynamic polymerization, the novel finding of the mechanism of action of actin in the INO80 chromatin-remodeling complex suggests a conceptually distinct mode of actin that functions as a monomer. In this review we highlight the new paradigm and discuss how actin interaction with chromatin suggests a fundamental divergence between conventional cytoplasmic actin and nuclear actin. Furthermore, we provide how this framework could be applied to investigations of nuclear actin in other actin-containing chromatin-modifying complexes.

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  • Specific nuclear events and gene transcription are regulated by the availability of monomeric actin, since various nuclear proteins, such as chromatin remodeling complexes, histone modifiers and RNA polymerases, require monomeric actin for their activity.

    “Notably, specific nuclear events and gene transcription are regulated by the availability of monomeric actin, since various nuclear proteins, such as chromatin remodeling complexes88, histone modifiers89 and RNA polymerases90,91, require monomeric actin for their activity.”

    From The WAVE complex in developmental and adulthood brain disorders (2025) · cites this paper as [88]

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Authors
Kapoor, P., & Shen, X.
Affiliations
The University of Texas MD Anderson Cancer Center (US)
Corresponding author
Shen, Xuetong
Venue
Trends in Cell Biology
Publisher
Elsevier BV
Published
2014-04
Volume
24
Issue
4
Pages
238-246
ISSN
0962-8924 (ISSN-L)
DOI
10.1016/j.tcb.2013.10.007
PMC
PMC3995414
OpenAlex
W2170720737
Cited by
137
References
0
Citations by year
2026: 5 · 2025: 7 · 2024: 14 · 2023: 11 · 2022: 6 · 2021: 14 · 2020: 14 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 13 · 2015: 12 · 2014: 2
FWCI
0.85
Type
journal article
Language
en
Open access
Locations
  • Trends in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Cancer Institute (K22CA100017, P30CA016672)
  • National Institute of General Medical Sciences (R01GM093104)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
nuclear actin, chromatin remodeling complexes, INO80 complex, actin polymerization, actin monomer, chromatin remodeling, cytoplasmic actin
MeSH terms
Actins, Animals, Cell Nucleus, Chromatin, Histones, Humans, Models, Biological, Chromatin Assembly and Disassembly

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