Connecting the dots between tau dysfunction and neurodegeneration
Open accessAbstract
Tauopathies are devastating and ultimately fatal neurodegenerative diseases, which are histopathologically defined by insoluble filamentous deposits of abnormally phosphorylated tau protein within neurons and glia. Identifying the causes of abnormal tau phosphorylation and subsequent aggregation has been the focus of much research, and is currently a major target for the development of therapeutic interventions for tauopathies, including Alzheimer's disease (AD). Much has recently been learned about the sequence of events that lead from tau dysfunction to neuronal death. This review focuses on the cascade of events that are catalyzed by pathological tau, and highlights current and potential therapeutic strategies to target this pathway.
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Ectopic expression of proteins associated with aberrant activation of the cell cycle in post-mitotic neurons is a well-described feature of human tauopathy.
“Ectopic expression of proteins associated with aberrant activation of the cell cycle in post-mitotic neurons is a well-described feature of human tauopathy25.”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [25]
Hyperphosphorylation of tau is a marker of progressive Alzheimer's disease in both humans and mice; its incidence increases as disease progresses and leads to microtubule de-stabilization and failure of the microtubule architecture, especially within neuronal axons.
“A marker of progressive AD in both humans and mice is the hyperphosphorylation of the microtubule-stabilizing protein tau. The incidence of tau phosphorylation increases as disease progresses and leads to microtubule de-stabilization and failure of the microtubule architecture, especially within neuronal axons (Frost et al., 2015; Gong and Iqbal, 2008; Noble et al., 2013).”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Frost et al., 2015
Tau phosphorylation is likely to promote axonal degeneration and eventual neuronal death.
“Because tau phosphorylation is likely to promote axonal degeneration and eventual neuronal death, we analyzed cell death within the brains of our 5xFAD models.”
From LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease (2019) · cites this paper as Frost et al., 2015
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References 93 · Cited by 124
- Authors
- Frost, B., Götz, J., & Feany, M. B.
- Affiliations
- Brigham and Women's Hospital (US)
- The University of Queensland (AU)
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 25
- Issue
- 1
- Pages
- 46-53
- ISSN
- 0962-8924 (ISSN-L)
- PMC
- PMC4275400
- OpenAlex
- W2004371219
- Cited by
- 124
- References
- 93
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 13 · 2020: 14 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 24 · 2015: 17 · 2014: 2
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R21AG028074, R01AG044113, R01AG033518, R21AG040796)
- National Institute of Neurological Disorders and Stroke (R01NS083391, K99NS088429)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- tauopathy, tau phosphorylation, tau aggregation, neurodegeneration, Alzheimer's disease, neuronal cell death, pathological tau
- MeSH terms
- Animals, Disease Models, Animal, Humans, Nerve Degeneration, Neuroglia, Neurons, Signal Transduction, tau Proteins, Tauopathies
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