Cellular Reorganization during Mitotic Entry
Abstract
The preparation of eukaryotic cells for division requires an extensive cellular reorganization, affecting cytoskeletal elements, chromatin, and organelles. These drastic changes in cellular architecture ensure the proper segregation of chromosomes and inheritance of organelles. The morphological alterations occurring during mitotic entry are tightly coordinated with the cell cycle, mainly through the action of mitotic kinases. Conversely, the fidelity of these processes impacts mitotic progression and is important for organismal homeostasis and cell fate. Here, we provide an overview of major architectural changes observed during early mitosis and review recent progress in understanding their regulatory mechanisms, focusing on processes accompanying mitotic cell rounding and restructuring of organelles in mammalian cells.
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Marked intracellular reorganization occurs as cells enter mitosis.
“We took advantage of the marked intracellular reorganization that occurs as cells enter mitosis28 to further examine the relationship between our suite of measurements of the average and relative locations and the variability of cellular structures.”
From Integrated intracellular organization and its variations in human iPS cells (2023) · cites this paper as [28]
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References 177 · Cited by 139
- Authors
- Champion, L., Linder, M. I., & Kutay, U.
- Affiliations
- ETH Zurich (CH)
- Corresponding author
- Kutay, Ulrike
- ORCID
- Kutay, Ulrike
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 27
- Issue
- 1
- Pages
- 26-41
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2508199124
- Cited by
- 139
- References
- 177
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 15 · 2023: 12 · 2022: 16 · 2021: 18 · 2020: 16 · 2019: 14 · 2018: 15 · 2017: 11 · 2016: 1
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- mitotic entry, cytoskeleton, chromatin, mitotic kinases, cell cycle regulation, chromosome segregation, organelle inheritance, mammalian cells
- MeSH terms
- Actomyosin, Animals, Cells, Humans, Mitosis, Models, Biological, Organelles, Focal Adhesions
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