The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics
Open accessAbstract
Membrane organelles consist of both proteins and lipids. Remodeling of these membrane structures is controlled by interactions between specific proteins and lipids. Mitochondrial structure and function depend on regulated fusion and the division of both the outer and inner membranes. Here, we will discuss recent advances on the regulation of mitochondrial dynamics by two critical phospholipids, phosphatidic acid and cardiolipin. These two lipids interact with the core components of mitochondrial fusion and division (Opa1, mitofusin, and Drp1) to activate and inhibit these dynamin-related GTPases. Moreover, lipid modifying enzymes such as phospholipases and lipid phosphatases may organize local lipid composition to spatially and temporarily coordinate a balance between fusion and division to establish mitochondrial morphology.
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Cites
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Cited by
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MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control
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DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
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Metadata
- Authors
- Kameoka, S., Adachi, Y., Okamoto, K., Iijima, M., & Sesaki, H.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 28
- Issue
- 1
- Pages
- 67-76
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2755685866
- Cited by
- 267
- References
- 89
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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