The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
No Parkin Zone: Mitophagy without Parkin
Abstract
Mitochondria are essential highly dynamic organelles that provide the necessary energy for a variety of different processes, such as survival, proliferation, and migration. In order to maintain an intact mitochondrial network, cells have developed quality control systems that allow the removal of damaged or superfluous mitochondria by selective mitochondrial autophagy called mitophagy. Although the parkin/PINK1 axis is often considered the main regulator of mitophagy, a growing body of evidence has shown that this pathway is not unique and that mitophagy can still be functional in the absence of parkin. Here, we will review recent literature describing parkin-independent mitophagy and its role in various physiopathological conditions, therefore representing potential new targets to treat diseases affected by dysregulated mitophagy.
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Cites
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
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Nix is a selective autophagy receptor for mitochondrial clearance
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Essential role for Nix in autophagic maturation of erythroid cells
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Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
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The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy
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Cited by
Ge, P., Dawson, V. L., & Dawson, T. M. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00367-7 · Cited by 496
Mitochondrial dysfunction and mitophagy in parkinson’s disease: from mechanism to therapy
Malpartida, A. B., Williamson, M., Narendra, D. P., Wade-Martins, R., & Ryan, B. J. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2020.11.007 · Cited by 482
Mitochondria as a therapeutic target for ischemic stroke
He, Z., Ning, N., Zhou, Q., Khoshnam, S. E., & Farzaneh, M. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.11.005 · Cited by 267
Autophagy and organelle homeostasis in cancer
Miller, D. R., & Thorburn, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.010 · Cited by 258
Patrick, K. L., Bell, S. L., Weindel, C. G., & Watson, R. O. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00138 · Cited by 110
Metadata
- Authors
- Villa, E., Marchetti, S., & Ricci, J.-E.
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 28
- Issue
- 11
- Pages
- 882-895
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W2886231497
- Cited by
- 221
- References
- 19
- FWCI
- 4.74
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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