Lipid droplet contact sites in health and disease
Open accessAbstract
After having been disregarded for a long time as inert fat drops, lipid droplets (LDs) are now recognized as ubiquitous cellular organelles with key functions in lipid biology and beyond. The identification of abundant LD contact sites, places at which LDs are physically attached to other organelles, has uncovered an unexpected level of communication between LDs and the rest of the cell. In recent years, many disease factors mutated in hereditary disorders have been recognized as LD contact site proteins. Furthermore, LD contact sites are dramatically rearranged in response to infections with intracellular pathogens, as well as under pathological metabolic conditions such as hepatic steatosis. Collectively, it is emerging that LD-organelle contacts are important players in development and progression of disease.
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Lipid droplets communicate closely through contact sites with other cellular organelles, including peroxisomes.
“To perform their functions efficiently, LDs communicate closely through contact sites with other cellular organelles, including peroxisomes [429,430].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [430]
The section ‘Lipid Droplets (LDs) Communicate via Organelle Contact Sites’ says LDs communicate extensively with other organelles through contact sites. Our copy does not establish peroxisomes as a specific contact partner; its mention of possible LD interactions with peroxisomal immune-signaling platforms says that involvement is not known. No page numbers are available in the indexed passages. (LLM, conf=0.78)
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- Authors
- Herker, E., Vieyres, G., Beller, M., Krahmer, N., & Bohnert, M.
- Affiliations
- Philipps University of Marburg (DE)
- Heinrich Heine University Düsseldorf (DE)
- Helmholtz Munich (DE)
- University of Münster (DE)
- Corresponding author
- Herker, Eva
- Beller, Mathias
- Krahmer, Natalie
- Bohnert, Maria
- Venue
- Trends in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 31
- Issue
- 5
- Pages
- 345-358
- ISSN
- 0962-8924 (ISSN-L)
- OpenAlex
- W3128445377
- Cited by
- 174
- References
- 3
- Citations by year
- 2026: 30 · 2025: 30 · 2024: 41 · 2023: 24 · 2022: 32 · 2021: 17
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Cell Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Site cant be reached (submittedVersion, cc-by-nc-nd)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by-nc-nd)
- Funders
- Helmholtz Zentrum München
- Deutsche Forschungsgemeinschaft
- Medizinische Fakultät, Westfälische Wilhelms-Universität Münster
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- lipid droplets, membrane contact sites, intracellular pathogens, hepatic steatosis, metabolic disorders, lipid biology
- MeSH terms
- Animals, Humans, Liver, Liver Diseases, Membrane Lipids, Lipid Metabolism, Non-alcoholic Fatty Liver Disease, Lipid Droplets
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