The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Chaperoning steroid hormone action
Open accessAbstract
Those that efface themselves in the action tend to be forgotten. But molecular chaperones are always there, often serving as equal partners. Because of their intrinsic functional frailty, a large number of signaling molecules have come to depend on molecular chaperones, notably the Hsp90 chaperone machine. This applies to the subset of nuclear receptors that converts steroid hormone signals to transcriptional outputs. Steroid receptors appear to rely on the Hsp90 machine for folding, regulation of the allosteric switch and recycling. This review discusses the complexities of the chaperone machinery and the diversity of regulatory options afforded by this assistance for hormone action.
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Cites
HSP90 and the chaperoning of cancer
Whitesell, L., & Lindquist, S. L. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1716 · Cited by 2,502
HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor
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Reduced levels of hsp90 compromise steroid receptor action in vivo
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Disassembly of Transcriptional Regulatory Complexes by Molecular Chaperones
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The Hsp90‐binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo
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Role of hsp90 and the hsp90-binding immunophilins in signalling protein movement
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Cited by
Schopf, F. H., Biebl, M. M., & Buchner, J. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.20 · Cited by 1,540
Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition
Taipale, M., Krykbaeva, I., Koeva, M., Kayatekin, C., Westover, K. D., Karras, G. I., & Lindquist, S. (2012) · Cell · doi:10.1016/j.cell.2012.06.047 · Cited by 879
The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression
Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727
Pharmacology of anabolic steroids
Kicman, A. T. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.165 · Cited by 580
Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches
McClellan, A. J., Xia, Y., Deutschbauer, A. M., Davis, R. W., Gerstein, M., & Frydman, J. (2007) · Cell · doi:10.1016/j.cell.2007.07.036 · Cited by 474
Metadata
- Authors
- Picard, D.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 17
- Issue
- 6
- Pages
- 229-235
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W1971727708
- Cited by
- 189
- References
- 14
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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