Importance of TNFα and neutral lipases in human adipose tissue lipolysis
Abstract
Catecholamines and natriuretic peptides stimulate human adipocyte lipolysis through an increase in cAMP and cGMP levels, resulting in phosphorylation and activation of hormone-sensitive lipase. A defect in hormone-sensitive lipase expression might contribute to the resistance to catecholamine-induced lipolysis observed in obesity. The respective roles and regulation of hormone-sensitive lipase and adipose triglyceride lipase in spontaneous and hormone-stimulated lipolysis remain to be determined. Tumor necrosis factor alpha stimulates triglyceride hydrolysis by multiple intracellular pathways acting on insulin signaling, G proteins and perilipins, and might contribute to enhanced plasma fatty acid levels in obesity. Characterization of the lipolytic pathways might provide novel strategies to decrease free fatty acid production and reverse insulin resistance and other obesity-related metabolic complications.
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TNF-α inhibits both the insulin and catecholamine signaling pathways in adipocytes, resulting in decreased metabolic flexibility.
“TNF-α inhibits both the insulin and the catecholamine signaling pathways in adipocytes, resulting in decreased metabolic flexibility”
From Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution (2021) · cites this paper as Langin and Arner, 2006
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References 75 · Cited by 140
- Authors
- Langin, D., & Arner, P.
- Affiliations
- Université Toulouse III - Paul Sabatier (FR)
- Karolinska University Hospital (SE)
- Corresponding author
- Langin, Dominique
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 17
- Issue
- 8
- Pages
- 314-320
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2004894972
- Cited by
- 140
- References
- 75
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 7
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tore Nilsons Stiftelse för Medicinsk Forskning
- Vetenskapsrådet
- Novo Nordisk Fonden
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- TNF-α, neutral lipase, adipose tissue lipolysis, hormone-sensitive lipase, adipose triglyceride lipase, catecholamines, natriuretic peptides, cyclic AMP, cyclic GMP, insulin resistance, obesity, free fatty acids, perilipin, G proteins, insulin signaling
- MeSH terms
- Adipose Tissue, Humans, Lipase, Lipolysis, Models, Biological, Triglycerides, Tumor Necrosis Factor-alpha, Adipocytes
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