Bone as an endocrine organ
Abstract
Although bone has long been recognized as a target for hormones influencing calcium and phosphorus homeostasis and bone structure, recent evidence shows that the skeleton itself produces at least two hormones, fibroblast growth factor 23 (FGF23) and osteocalcin. FGF23 is produced by osteocytes in bone and acts on the kidney to inhibit 1alpha-hydroxylation of vitamin D and promote phosphorus excretion. Mouse genetics studies revealed that the osteoblast product, osteocalcin, acts on the pancreatic beta-cell to enhance insulin production and on peripheral tissues to increase glucose utilization as a result of increased insulin sensitivity and to reduce visceral fat. This review highlights the recent studies indicating bone's role as an endocrine organ.
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Bone influences the activity of other organs and is influenced by other organs and systems of the body.
“Recent studies have shown that bone influences the activity of other organs and the bone is also influenced by other organs and systems of the body [21]”
From Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015) · cites this paper as [21]
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References 67 · Cited by 311
- Authors
- Fukumoto, S., & Martin, T. J.
- Affiliations
- University of Tokyo Hospital (JP)
- The University of Melbourne (AU)
- ORCID
- Fukumoto, Seiji
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 20
- Issue
- 5
- Pages
- 230-236
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2067513456
- Cited by
- 311
- References
- 67
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 7 · 2022: 14 · 2021: 18 · 2020: 19 · 2019: 26 · 2018: 20 · 2017: 21 · 2016: 14 · 2015: 28 · 2014: 25 · 2013: 26 · 2012: 21
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Keywords
- bone as endocrine organ, fibroblast growth factor 23, osteocalcin, osteocytes, osteoblasts, calcium homeostasis, phosphorus homeostasis, renal phosphate excretion, pancreatic beta cells, insulin secretion, insulin sensitivity, glucose utilization, visceral fat
- MeSH terms
- Fibroblast Growth Factor-23, Animals, Bone and Bones, Fibroblast Growth Factors, Humans, Insulin, Models, Biological, Vitamin D, Osteocalcin
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