The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hepatitis C virus hijacks host lipid metabolism
Open accessAbstract
Hepatitis C virus (HCV) modulates cellular lipid metabolism to enhance its replication. HCV circulates in the blood in association with lipoproteins. HCV infection is associated with enhanced lipogenesis, reduced secretion and β-oxidation of lipids. HCV-induced imbalance in lipid homeostasis leads to steatosis. Many lipids are crucial for viral life cycle, and inhibitors of cholesterol/fatty acid biosynthetic pathways inhibit viral replication, maturation and secretion. HCV negatively modulates the synthesis and secretion of very low-density lipoproteins (VLDL). The components involved in VLDL assembly are also required for HCV morphogenesis/secretion, suggesting that HCV coopts the VLDL secretory pathway for its own secretion. This review highlights HCV-altered lipid metabolic events that aid in the viral life cycle and ultimately promote liver disease pathogenesis.
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Cites
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism
Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786
Cited by
Autophagy Protects Cells From HCV-Induced Defects in Lipid Metabolism
Vescovo, T., Romagnoli, A., Perdomo, A. B., Corazzari, M., Ciccosanti, F., Alonzi, T., Nardacci, R., Ippolito, G., Tripodi, M., Garcia–Monzon, C., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2011.11.033 · Cited by 69
Lipid droplets as signaling platforms linking metabolic and cellular functions
Arrese, E. L., Saudale, F. Z., & Soulages, J. L. (2014) · Lipid Insights · doi:10.4137/lpi.s11128 · Cited by 54
Metadata
- Authors
- Syed, G. H., Amako, Y., & Siddiqui, A.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 21
- Issue
- 1
- Pages
- 33-40
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2047028523
- Cited by
- 363
- References
- 2
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
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