The DOI matches its Crossref record; 64 of the 66 references it cites were found in a registry or an index.
Epigenetic mechanisms in the development of type 2 diabetes
Open accessAbstract
Type 2 diabetes (T2D) is a disorder of complex genetics influenced by interactions between susceptible genetic loci and environmental perturbations. Intrauterine growth retardation is one such environmental perturbation linked to the development of T2D in adulthood. An abnormal metabolic intrauterine milieu affects fetal development by permanently modifying expression of key genes regulating beta-cell development (Pdx1) and glucose transport (Glut4) in muscle. Epigenetic regulation of gene expression is one mechanism by which genetic susceptibility and environmental insults can lead to T2D. Therefore, therapeutic agents targeting epigenetic gene regulation can ultimately be used to treat T2D; however, there is much to be learned about genome-wide epigenetic programming of health and disease before these therapies can be used in patient care.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This loss of β-cell mass has been linked to epigenetic downregulation of pancreatic homeobox transcription factor (Pdx1), which is essential for normal β-cell differentiation in the embryo [79].”
From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [79]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Aberrant promoter methylation of multiple genes during multistep pathogenesis of colorectal cancers
Takahashi, T., Shigematsu, H., Shivapurkar, N., Reddy, J., Zheng, Y., Feng, Z., Suzuki, M., Nomura, M., Augustus, M., Yin, J., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21453 · Cited by 42
RetractedWild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297
Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,094
Fetal and infant growth and impaired glucose tolerance at age 64
Hales, C. N., Barker, D. J., Clark, P. M., Cox, L. J., Fall, C., Osmond, C., & Winter, P. D. (1991) · BMJ · doi:10.1136/bmj.303.6809.1019 · Cited by 2,708
Linking DNA methylation and histone modification: patterns and paradigms
Cedar, H., & Bergman, Y. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2540 · Cited by 2,267
Obesity at the age of 50 y in men and women exposed to famine prenatally
Ravelli, A. C. J., van der Meulen, J., Osmond, C., Barker, D. J. P., & Bleker, O. P. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.5.811 · Cited by 1,165
Monk, M., Boubelı́k, M., & Lehnert, S. A. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,100
Genomic and Epigenetic Instability in Colorectal Cancer Pathogenesis
Grady, W. M., & Carethers, J. M. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.07.076 · Cited by 991
A high-resolution map of active promoters in the human genome
Kim, T. H., Barrera, L. O., Zheng, M., Qu, C., Singer, M. A., Richmond, T., Wu, Y., Green, R. D., & Ren, B. (2005) · Nature · doi:10.1038/nature03877 · Cited by 954
Flagged first, then by citations
2 of the 66 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–203 of 203
Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing
Gauda, E. B., Ivanovska, J., Mascarenhas, D., Antwi, J., Mohammadi, A., & Jasani, B. (2026) · The Journal of Physiology · doi:10.1113/jp289277 · Cited by 1
Gene-environment interaction in type 2 diabetes mellitus (T2DM)
Sohtun, L. P., & Aguan, K. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-33590-7.00017-4
Early origins of disease: Fetal
Martin‐Gronert, M. S., & Ozanne, S. E. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-375083-9.00081-7
Metadata
- Authors
- Pinney, S. E., & Simmons, R. A.
- Affiliations
- Children's Hospital of Philadelphia (US)
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 21
- Issue
- 4
- Pages
- 223-229
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC2848901
- OpenAlex
- W1977200537
- Cited by
- 205
- References
- 66
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 13 · 2016: 14 · 2015: 17 · 2014: 22 · 2013: 27 · 2012: 19
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG020898)
- National Institute of Diabetes and Digestive and Kidney Diseases (L40 DK079770, R01DK055704, DK-55704)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD0432545)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- type 2 diabetes, epigenetic regulation, fetal growth restriction, fetal programming, beta-cell development, PDX1, GLUT4, gene-environment interaction, epigenetic therapy, gene expression
- MeSH terms
- Diabetes Mellitus, Type 2, Fetal Growth Retardation, Gene Expression Regulation, Histones, Humans, Trans-Activators, Oxidative Stress, Homeodomain Proteins, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Glucose Transporter Type 4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
