Crosstalk between reverse cholesterol transport and innate immunity
Open accessAbstract
Although lipid metabolism and host defense are widely considered to be very divergent disciplines, compelling evidence suggests that host cell handling of self- and microbe-derived (e.g. lipopolysaccharide, LPS) lipids may have common evolutionary roots, and that they indeed may be inseparable processes. The innate immune response and the homeostatic network controlling cellular sterol levels are now known to regulate each other reciprocally, with important implications for several common diseases, including atherosclerosis. In the present review we discuss recent discoveries that provide new insight into the bidirectional crosstalk between reverse cholesterol transport and innate immunity, and highlight the broader implications of these findings for the development of therapeutics.
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The observed expression changes in the cholesterol transport-related genes are compatible with those in down-regulation of LXR activity.
“However, it can be noted that the observed expression changes in the cholesterol transport-related genes are compatible with those in down-regulation of LXR activity3957 (Fig. 3).”
From Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses (2016) · cites this paper as [57]
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References 104 · Cited by 96
- Authors
- Azzam, K. M., & Fessler, M. B.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Fessler, Michael B.
- ORCID
- Fessler, Michael B.
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 23
- Issue
- 4
- Pages
- 169-178
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC3338129
- OpenAlex
- W1971988880
- Cited by
- 96
- References
- 104
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 13 · 2016: 10 · 2015: 8 · 2014: 6 · 2013: 5 · 2012: 1
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (Z01ES102005, ZIAES102005)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- reverse cholesterol transport, innate immunity, sterol homeostasis, lipid metabolism, lipopolysaccharide, atherosclerosis, host defense, therapeutic target
- MeSH terms
- Animals, Biological Transport, Cholesterol, Humans, Immunity, Innate, Models, Biological
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