Mitochondrial sirtuins: regulators of protein acylation and metabolism
Abstract
Sirtuins are NAD(+)-dependent protein deacetylases and have been implicated in the regulation of metabolism, stress responses, and aging. Three sirtuins are located in mitochondria: SIRT3, 4, and 5. SIRT3 deacetylates and regulates the enzymatic activity of many metabolic enzymes in mitochondria, whereas SIRT5 removes two novel post-translational modifications, lysine malonylation and succinylation. Here, we review the current knowledge of how mitochondrial sirtuins function in metabolism and metabolic diseases, and offer a conceptual model how they may regulate mitochondrial function through distinct deacylation activities (deacetylation, demalonylation, or desuccinylation).
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Some sirtuin family members mediate non-acetyl lysine acylations, such as succinylation, malonylation and fatty acid acylation, whose cellular functions are poorly understood.
“Additionally, some members of the sirtuin family mediate non-acetyl lysine acylations (for example, succinylation, malonylation and fatty acid acylation)13–15, the cellular functions of which are so far poorly understood16.”
From NAD+ metabolism and its roles in cellular processes during ageing (2021) · cites this paper as [15]
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References 100 · Cited by 262
- Authors
- He, W., Newman, J. C., Wang, M. Z., Ho, L., & Verdin, E.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 23
- Issue
- 9
- Pages
- 467-476
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2045303676
- Cited by
- 262
- References
- 100
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 10 · 2023: 15 · 2022: 12 · 2021: 19 · 2020: 23 · 2019: 15 · 2018: 19 · 2017: 20 · 2016: 15 · 2015: 32 · 2014: 26 · 2013: 29 · 2012: 2
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (P30AI027763)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial sirtuins, SIRT3, SIRT4, SIRT5, NAD+-dependent deacetylase, protein acylation, lysine malonylation, lysine succinylation, desuccinylation, mitochondrial metabolism, metabolic disorders, aging, stress response
- MeSH terms
- Acylation, Animals, Humans, Mitochondrial Proteins, Sirtuins
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