Lessons from C. elegans: signaling pathways for longevity
Open accessAbstract
Recent research using model organisms such as the nematode Caenorhabditis elegans has highlighted a crucial role for several conserved signaling pathways in longevity determination. Here, we review three major endocrine- and nutrient-sensing signaling pathways with influence on lifespan, the insulin/insulin-like growth factor (IGF), target of rapamycin (TOR), and germline signaling pathways. Although these pathways engage distinct sets of transcription factors, the three pathways appear to modulate aging in C. elegans through partially overlapping effector mechanisms, including lipid metabolism and autophagy. This review highlights the latest advances in our understanding of how the insulin/IGF-1, TOR, and germline signaling pathways utilize different transcription factors to modulate aging in C. elegans with special emphasis on the role of lipid metabolism and autophagy.
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The round worm Caenorhabditis elegans is used to investigate metabolic pathways and has been instrumental in elucidating key genetic regulators of metabolism in relation to lifespan.
“The round worm Caenorhabditis elegans, for instance, is used to investigate metabolic pathways and has been instrumental in elucidating key genetic regulators of metabolism in relation to lifespan (36, 293, 294).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [294]
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References 80 · Cited by 331
- Authors
- Lapierre, L. R., & Hansen, M.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Corresponding author
- Hansen, Malene
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 23
- Issue
- 12
- Pages
- 637-644
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC3502657
- OpenAlex
- W2001302985
- Cited by
- 331
- References
- 80
- Citations by year
- 2026: 27 · 2025: 28 · 2024: 19 · 2023: 27 · 2022: 23 · 2021: 20 · 2020: 18 · 2019: 29 · 2018: 21 · 2017: 19 · 2016: 28 · 2015: 22 · 2014: 35 · 2013: 13 · 2012: 2
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ellison Medical Foundation
- National Institutes of Health
- National Institute on Aging (P50AG005131, R01AG039756, R01AG038664)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- Caenorhabditis elegans, aging, longevity, insulin/IGF-1 signaling, TOR signaling, nutrient sensing, hormone signaling, transcription factors, lipid metabolism, autophagy
- MeSH terms
- Aging, Animals, Autophagy, Insulin-Like Growth Factor I, Longevity, Transcription Factors, Signal Transduction, Caenorhabditis elegans, Germ-Line Mutation, Caenorhabditis elegans Proteins, Forkhead Transcription Factors, AMP-Activated Protein Kinases, TOR Serine-Threonine Kinases
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