Retinoid X receptors in macrophage biology
Open accessAbstract
Retinoid X receptors (RXRs) form a distinct and unique subclass within the nuclear receptor (NR) superfamily of ligand-dependent transcription factors. RXRs regulate a plethora of genetic programs, including cell differentiation, the immune response, and lipid and glucose metabolism. Recent advances reveal that RXRs are important regulators of macrophages, key players in inflammatory and metabolic disorders. This review outlines the versatility of RXR action in the control of macrophage gene transcription through its heterodimerization with other NRs or through RXR homodimerization. We also highlight the potential of RXR-controlled transcriptional programs as targets for the treatment of pathologies associated with altered macrophage function, such as atherosclerosis, insulin resistance, autoimmunity, and neurodegeneration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Expression of numerous efferocytosis/clearance-associated genes in cerebellar microglia comprises a set encoding transcription factors implicated in regulation of macrophage polarization, clearance, and differentiation, including AHR, TFEC, and RARG.
“The expression of numerous efferocytosis/clearance-associated genes in cbMg comprises a set that encodes transcription factors implicated in the regulation of macrophage polarization, clearance, and differentiation, including AHR36, TFEC37, and RARG38.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [38]
The citation lists haven’t been fetched yet
References 81 · Cited by 137
- Authors
- Rőszer, T., Menéndez-Gutiérrez, M. P., Cedenilla, M., & Ricote, M.
- Affiliations
- Spanish National Centre for Cardiovascular Research (ES)
- Corresponding author
- Ricote, Mercedes
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 24
- Issue
- 9
- Pages
- 460-468
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W1992438813
- Cited by
- 137
- References
- 81
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 6 · 2023: 13 · 2022: 15 · 2021: 16 · 2020: 15 · 2019: 13 · 2018: 13 · 2017: 9 · 2016: 6 · 2015: 9 · 2014: 4 · 2013: 4
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- retinoid X receptor, macrophages, nuclear receptors, heterodimerization, homodimerization, gene transcription, inflammation, metabolic disorders, atherosclerosis, insulin resistance, autoimmunity, neurodegeneration
- MeSH terms
- Animals, Humans, Immunity, Innate, Macrophages, Retinoid X Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
