FGF21-based pharmacotherapy – potential utility for metabolic disorders

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Xu, J., Lloyd, D. J., Hale, C., Stanislaus, S., Chen, M., Sivits, G., Vonderfecht, S., Hecht, R., Li, Y.-S., Lindberg, R. A., et al. (2009) · Diabetes · doi:10.2337/db08-0392 · Cited by 1,151

Fibroblast Growth Factor 21 Corrects Obesity in Mice

Coskun, T., Bina, H. A., Schneider, M. A., Dunbar, J. D., Hu, C. C., Chen, Y., Moller, D. E., & Kharitonenkov, A. (2008) · Endocrinology · doi:10.1210/en.2008-0816 · Cited by 1,031

The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes

Gaich, G., Chien, J. Y., Fu, H., Glass, L. C., Deeg, M. A., Holland, W. L., Kharitonenkov, A., Bumol, T., Schilske, H. K., & Moller, D. E. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.08.005 · Cited by 885

Obesity Is a Fibroblast Growth Factor 21 (FGF21)-Resistant State

Fisher, F. M., Chui, P. C., Antonellis, P. J., Bina, H. A., Kharitonenkov, A., Flier, J. S., & Maratos-Flier, E. (2010) · Diabetes · doi:10.2337/db10-0193 · Cited by 830

Irisin and FGF21 are cold-induced endocrine activators of brown fat function in humans

Lee, P., Linderman, J. D., Smith, S., Brychta, R. J., Wang, J., Idelson, C., Perron, R. M., Werner, C. D., Phan, G. Q., Kammula, U. S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.017 · Cited by 802

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Kim, K. H., Jeong, Y. T., Oh, H., Kim, S. H., Cho, J. M., Kim, Y.-N., Kim, S. S., Kim, D. H., Hur, K. Y., Kim, H. K., et al. (2013) · Nature Medicine · doi:10.1038/nm.3014 · Cited by 774

Dual effects of fibroblast growth factor 21 on hepatic energy metabolism

Samms, R. J., Murphy, M., Fowler, M. J., Cooper, S., Emmerson, P. J., Coşkun, T., Adams, A. C., Kharitonenkov, A., Ebling, F. J. P., & Tsintzas, K. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0334 · Cited by 17

Influence of Adipokines on Metabolic Dysfunction and Aging

Park, S., & Shimokawa, I. (2024) · Biomedicines · doi:10.3390/biomedicines12040873 · Cited by 20

Mediterranean Tomato‐Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats

Sandoval, V., Rodríguez‐Rodríguez, R., Martínez‐Garza, Ú., Rosell‐Cardona, C., Lamuela-Raventós, R. M., Marrero, P. F., Haro, D., & Relat, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700606 · Cited by 17

Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment

Yang, Y., Zhao, Y., Li, W., Wu, Y., Wang, X., Wang, Y., Liu, T.-M., Ye, T., Xie, Y., Cheng, Z., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112311 · Cited by 17

Gene expression in WAT from healthy humans and monkeys correlates with FGF 21‐induced browning of WAT in mice

Schlessinger, K., Li, W., Tan, Y., Liu, F., Souza, S. C., Tozzo, E., Liu, K., Thompson, J. R., Wang, L., & Muise, E. S. (2015) · Obesity · doi:10.1002/oby.21153 · Cited by 17

Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice

Hetherington, A. M., Sawyez, C. G., Sutherland, B. G., Robson, D. L., Arya, R., Kelly, K. B., Jacobs, R. L., & Borradaile, N. M. (2016) · Physiological Reports · doi:10.14814/phy2.12963 · Cited by 18

Oral administration of a new HRI activator as a new strategy to improve high‐fat‐diet‐induced glucose intolerance, hepatic steatosis, and hypertriglyceridaemia through FGF21

Zarei, M., Pujol, E., Quesada‐López, T., Villarroya, F., Barroso, E., Vázquez, S., Pizarro‐Delgado, J., Palomer, X., & Vázquez‐Carrera, M. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14678 · Cited by 17

Enhanced expression and distinctive characterization of a long-acting FGF21 and its potential to alleviate nonalcoholic steatohepatitis

Yin, J., Bao, L., Chen, R., Gao, W. Y., Gao, X., & Yao, W. (2018) · Biochimie · doi:10.1016/j.biochi.2018.05.020 · Cited by 16

Effect of Fibroblast Growth Factor 21 on the Development of Atheromatous Plaque and Lipid Metabolic Profiles in an Atherosclerosis-Prone Mouse Model

Maeng, H. J., Lee, G. Y., Bae, J. H., & Lim, S. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186836 · Cited by 16

Recruitment of Thermogenic Fat: Trigger of Fat Burning

Wang, Z., Yu, X., & Chen, Y. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.696505 · Cited by 16

FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function

Chen, P., Xu, B., Feng, Y., Li, K., Liu, Z., Sun, X., Lu, X., Wang, L., Chen, Y.-W., Fan, X., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.10.003 · Cited by 15

The U-shaped relationship between fibroblast growth factor 21 and microvascular complication in type 2 diabetes mellitus

Jung, C., Jung, S.-H., Kim, B., Kim, C., Kang, S., & Mok, J. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.017 · Cited by 15

Deciphering adipose development: Function, differentiation and regulation

Guo, G., Wang, W., Tu, M., Zhao, B., Han, J., Li, J., Pan, Y., Zhou, J., Ma, W., Liu, Y., et al. (2024) · Developmental Dynamics · doi:10.1002/dvdy.708 · Cited by 16

The Role of Brown Adipose Tissue in Cardiovascular Disease Protection: Current Evidence and Future Directions

Pereira, R. O., & McFarlane, S. I. (2019) · International Journal of Clinical Research & Trials · doi:10.15344/2456-8007/2019/136 · Cited by 14

Ileal Transposition Surgery Decreases Fat Mass and Improves Glucose Metabolism in Diabetic GK Rats: Possible Involvement of FGF21

Yan, K., Chen, W., Zhu, H., Lin, G., Pan, H., Li, N., Wang, L., Yang, H., Liu, M., & Gong, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00191 · Cited by 13

Digenic Variants in the FGF21 Signaling Pathway Associated with Severe Insulin Resistance and Pseudoacromegaly

Stone, S., Wegner, D., Wambach, J., Cole, F. S., Urano, F., & Ornitz, D. M. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa138 · Cited by 12

Attenuation of FGF21 signalling might aggravate the impairment of glucose homeostasis during the high sucrose diet induced transition from prediabetes to diabetes in WNIN/GR-Ob rats

Kondeti, S., Dinesh Yadav, D. M., Muralidhar, M. N., Prasad, S. M. V. K., Nemani, H., & Kalashikam, R. R. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111252 · Cited by 12

Ascorbic acid attenuates cell stress by activating the�fibroblast growth factor 21/fibroblast growth factor receptor�2/adiponectin pathway in HepG2 cells

Gu, X., Luo, X. M., Wang, Y., He, Z., Li, X., Wu, K., Zhang, Y., Yang, Y., Ji, J., & Luo, X. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10457 · Cited by 13

A Comprehensive Review of Novel Drug–Disease Models in Diabetes Drug Development

Gaitonde, P., Garhyan, P., Link, C., Chien, J. Y., Trame, M. N., & Schmidt, S. (2016) · Clinical Pharmacokinetics · doi:10.1007/s40262-015-0359-y · Cited by 12

Spinal Cord Injury Reduces Serum Levels of Fibroblast Growth Factor-21 and Impairs Its Signaling Pathways in Liver and Adipose Tissue in Mice

Liu, X., Graham, Z., Harlow, L., Pan, J., Azulai, D., Bauman, W. A., Yarrow, J. F., & Cardozo, C. P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668984 · Cited by 12

Circulating mitokines GDF-15 and FGF21 are associated with frailty, sarcopenia, and malnutrition in older adults: Evidence from the FRASNET study

Damanti, S., Sciorati, C., LORENZO, R. D., Avola, A., Ruggiero, M. P., Santoro, S., Senini, E., Messina, M., Farina, F., Festorazzi, C., et al. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112124 · Cited by 13

Activating Connexin43 gap junctions primes adipose tissue for therapeutic intervention

Zhu, Y., Li, N., Huang, M., Chen, X., An, Y., Li, J., Zhao, S., Funcke, J., Cao, J., He, Z., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.020 · Cited by 12

Hepatic Fgf21 Expression Is Repressed after Simvastatin Treatment in Mice

Ziros, P. G., Zagoriti, Z., Lagoumintzis, G., Kyriazopoulou, V. E., Iskrenova, R. P., Habeos, E. E., Sykiotis, G. P., Chartoumpekis, D. V., & Habeos, I. G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162024 · Cited by 11

High baseline FGF21 levels are associated with poor glucose-lowering efficacy of exenatide in patients with type 2 diabetes

Yang, K., Wang, H., Wei, R., Xiao, W., Tian, Q., Wang, C., Yang, J., & Hong, T. (2021) · Acta Diabetologica · doi:10.1007/s00592-020-01660-z · Cited by 9

Increased FGF21 in brown adipose tissue of tyrosine hydroxylase heterozygous mice: implications for cold adaptation

Vázquez, P., Hernández‐Sánchez, C., Escalona-Garrido, C., Pereira, L., Contreras, C., López, M., Balsinde, J., de Pablo, F., & Valverde, Á. M. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m085209 · Cited by 10

Fibroblast Growth Factor 21 Mimetics for Treating Atherosclerosis

Kwok, K. H. M., & Lam, K. S. L. (2017) · Endocrinology and Metabolism · doi:10.3803/enm.2017.32.2.145 · Cited by 9

A New FGF21 Analog for the Treatment of Fatty Liver Disease

Kleinert, M., & Müller, T. D. (2020) · Diabetes · doi:10.2337/dbi20-0025 · Cited by 9

FGF21-protection against fructose-induced lipid accretion and oxidative stress is influenced by maternal nutrition in male progeny

Fauste, E., Rodrigo, S., Rodríguez, L., Donis, C., Garcı́a, A., Barbas, C., Álvarez‐Millán, J. J., Panadero, M. I., Otero, P., & Bocos, C. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103676 · Cited by 9

Effects and Safety of FGF21 Analogs on Glycemic Parameters, Lipid Profiles, and Adiponectin in Overweight and Obese Adults: A Meta‐Analysis of Randomized Controlled Trials

Nie, Z., Xu, J., Liu, Y., Cao, Q., Qiu, X., Su, Y., & Han, S. (2025) · International Journal of Endocrinology · doi:10.1155/ije/9943228 · Cited by 8

Fructose Protects Against Acetaminophen‐Induced Hepatotoxicity Mainly by Activating the Carbohydrate‐Response Element‐Binding Protein α–Fibroblast Growth Factor 21 Axis in Mice

Zhang, D., Wang, S., Ospina, E., Shabandri, O., Lank, D. S., Akakpo, J. Y., Zhao, Z., Yang, M., Wu, J., Jaeschke, H., et al. (2021) · Hepatology Communications · doi:10.1002/hep4.1683 · Cited by 8

Intramyocardial Adipose-Derived Stem Cell Transplantation Increases Pericardial Fat with Recovery of Myocardial Function after Acute Myocardial Infarction

Kim, J.-H., Hong, S. J., Park, C., Park, J. H., Choi, S., Woo, S., Yu, J. W., Cheon, G. J., Joo, H. J., & Lim, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158067 · Cited by 8

Fıbroblast growth factor 21 and ıts relatıonshıp wıth ınsulın sensıtıvıty ın fırst-degree relatıves of patıents wıth type 2 dıabetes mellıtus

Ors, D., Altınova, A. E., Yalçın, M. M., Gülbahar, Ö., Aktürk, M., Arslan, M., & Törüner, F. B. (2015) · Endokrynologia Polska · doi:10.5603/ep.a2016.0016 · Cited by 6

Evaluation of a PEGylated Fibroblast Growth Factor 21 Variant Using Novel Preclinical Magnetic Resonance Imaging and Magnetic Resonance Elastography in a Mouse Model of Nonalcoholic Steatohepatitis

Tang, H., Li, J., Zinker, B. A., Boehm, S., Mauer, A. S., Rex‐Rabe, S., Glaser, K. J., Fronheiser, M. P., Bradstreet, T. E., Nakao, Y., et al. (2022) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28077 · Cited by 6

The liver-bone axis: an emerging player in disease pathogenesis and therapeutic intervention

Han, S., Wei, Y., Yu, G., Jia, W., Liao, W., He, Y., Cheng, K., Zhao, J., Xiang, S., Zhang, W., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3207-5 · Cited by 5

Seed- and leaf-based expression of FGF21-transferrin fusion proteins for oral delivery and treatment of non-alcoholic steatohepatitis

Hou, H.-W., Bishop, C. A., Huckauf, J., Broer, I., Klaus, S., Nausch, H., & Buyel, J. F. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.998596 · Cited by 5

PF-05231023 reduces lipid deposition in apolipoprotein E-deficient mice by inhibiting the expression of lipid synthesis genes

Juan, Z., Liu, X., Yue, J., Zhang, S., Li, L., & Wei, H. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1429639 · Cited by 5

Fibroblast growth factor 21 signaling: The liver in focus

Mahlapuu, M., & Marschall, H. (2016) · Hepatology · doi:10.1002/hep.28591 · Cited by 5

Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine

Hirai, T., Wang, W., Murono, N., Iwasa, K., & Inoue, M. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01755-1 · Cited by 4

Effect of Moderate Aerobic Exercise on Serum Levels of FGF21 and Fetuin A in Women with Type 2 Diabetes

Vizvari, E., Farzanegi, P., & Sourati, H. A. (2020) · Medical Laboratory Journal · doi:10.52547/mlj.14.6.17 · Cited by 4

A combination of Citrus aurantifolia fruit rind and Theobroma cacao seed extracts supplementation enhances metabolic rates in overweight subjects: a randomized, placebo-controlled, cross-over study

Ammatalli, N. K. R., Kuricheti, S. S. S. K., Veeramachaneni, S., Koo, Y. K., Ramanathan, G., & Yalamanchi, A. (2024) · Food & Nutrition Research · doi:10.29219/fnr.v68.10745 · Cited by 4

Lentivirus-Mediated hFGF21 Stable Expression in Liver of Diabetic Rats Model and Its Antidiabetic Effect Observation

Lu, S., Liu, G., Chen, T., Wang, W., Hu, J., Tang, D., & Peng, X. (2020) · Human Gene Therapy · doi:10.1089/hum.2019.322 · Cited by 3

Cardiometabolic Syndrome and Effects of Yoga

Chatterjee, S., & Bhattacharya, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-6913-2_15 · Cited by 4

Fibroblast growth factor-21 is a novel linkage between metabolic parameters, cardiovascular risk, and nephropathy in prediabetes

Matta, R., El-Hini, S. H., Saad, M., Mostafa, H., & AbedelfadeeL, A. (2017) · Egyptian Journal of Obesity Diabetes and Endocrinology · doi:10.4103/ejode.ejode_30_16 · Cited by 3

P rocess development of a FGF21 protein–antibody conjugate

Dirksen, A., Davis, K. A., Collins, J. T., Bhattacharya, K., Finneman, J. I., Pepin, E., Ryczek, J., Brown, P. W., Wellborn, W. B., Mangalathillam, R., et al. (2017) · Peptide Science · doi:10.1002/bip.23042 · Cited by 2

The role of increased FGF21 in VLDL-TAG secretion and thermogenic gene expression in mice under protein malnutrition

Ozaki‐Masuzawa, Y., Kosaka, H., Abiru, R., Toda, Y., Kawabata, K., Nagata, M., Hara, S., Konishi, M., Itoh, N., Hosono, T., et al. (2021) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbab030 · Cited by 2

Impact of exercise-induced irisin on bones of osteoporotic male rat model

Moghazy, H. M., Mahmoud, A. A., Gebril, S. M., Foad, A. M., Refaei, R. A., & Abdel-Fadeil, M. R. (2023) · Gene Reports · doi:10.1016/j.genrep.2023.101804 · Cited by 2

Probiotic Lactobacillus Acidophilus prevents bone loss in aged osteoporosis in rats; the possible implication of NLRP3 Inflammasome

Allam, M. M., Anwer, H. M., Gazzar, W. B. E., Ahmed, N., & El-Shaer, N. O. (2023) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2023.206894.1141 · Cited by 2

Association between circulating inflammatory proteins and gout: A Mendelian randomization study

Xie, X., Song, Y., Chen, W., Zhao, H., Chu, N., & Wang, F. (2025) · Medicine · doi:10.1097/md.0000000000042379 · Cited by 2

Transmembrane G protein-coupled receptor 5 signaling stimulates fibroblast growth factor 21 expression concomitant with up-regulation of the transcription factor nuclear receptor Nr4a1

Kiyama, G., Nakashima, K., Shimada, K., Murono, N., Kakihana, W., Imai, H., Inoue, M., & Hirai, T. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112078 · Cited by 2

The effect of fibroblast growth factor 21 on a mouse model of bovine viral diarrhea

Zhao, D., Song, Y.-H., Song, J., Shi, K., Li, J., Diao, N.-C., Zong, Y., Zeng, F.-L., & Du, R. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1104779 · Cited by 1

Association between Plasma FGF21 Levels and Body Composition in Patients with Gastric Cancer

Zhang, Y., Jiang, L., Su, P., Ma, Z., Kang, W., Ye, X., Liu, Y., & Yu, J. (2022) · Nutrition and Cancer · doi:10.1080/01635581.2022.2118322 · Cited by 1

Biomarkers of Insulin Resistance

Cox‐York, K. A., & Pereira, R. I. (2019) · Contemporary Endocrinology · doi:10.1007/978-3-030-25057-7_11 · Cited by 1

Energy status and ovarian follicular development

Meng, L. (2016) · doi:10.18174/389440

Novel targets for the development of drugs for Type 2 Diabetes Mellitus

Sotiriou, A. (2016) · doi:10.18174/399762

The Sweet Path to Metabolic Demise: Fructose and Lipid

Herman, S. A., & Samuel, V. T. (2016)

Hormonal Responses that Regulate the Metabolic Benefits of Exercise: The Contribution of the Melanocortin System and the Fibroblast Growth Factor 21 (FGF21) Signaling Pathway

Loyd, C. (2014) · OhioLink ETD Center (Ohio Library and Information Network)

Exercise alleviates osteoporotic changes in glucocorticoids- induced osteoporosis in a rat model: a possible role of endogenous irisin

Mohamed, M., Shabanah, M., Samir, S. M., Gad, G. E. M., & Elserougy, H. G. (2020) · Bulletin of Egyptian Society for Physiological Sciences · doi:10.21608/besps.2020.29480.1058

Mistranslation drives alterations in protein levels and the effects of a synonymous variant at the FGF21 locus

Bayoumi, A. (2020) · The Sydney eScholarship Repository (The University of Sydney)

Additional file 1 of Mesenchymal stem cells modified by FGF21 and GLP1 ameliorate lipid metabolism while reducing blood glucose in type 2 diabetic mice

Xue, B., Xiao, X., Yu, T., Xiao, X., Xie, J., Ji, Q., Wang, L., Na, T., Meng, S., 钱令嘉, et al. (2021) · Figshare · doi:10.6084/m9.figshare.14037548

Revealing causal associations of 91 inflammatory protein factors with endocarditis: Insights from genome-wide association study

Jiang, X., Guan, Y., Chen, C., & wu, X. (2026) · Medicine · doi:10.1097/md.0000000000048141

Fonction de la signalisation de l'insuline dans le foie : impact sur la régulation de l'horloge circadienne et le dimorphisme sexuel de l'homéostasie glucidique

Fougeray, T. (2020) · theses.fr (ABES) · doi:10.70675/e11b5642z6033z40dcz8940z03901fb000a2

rhFGF21-loaded P hydrogel promoted diabetic wound repair by regulating the inflammatory cytokine expression and phagocytic function of macrophages via the STING-mediated autophagy pathway

Li, J., Qiu, R., Ye, S., Lin, J., Wu, J., Wang, Y., Chen, J. P., & Zhao, Y. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116857

FGF21/sirtuin 1 axis mediates the cardioprotective effects of high‐intensity interval training against doxorubicin‐induced cardiotoxicity by reducing inflammatory and oxidative stress

Farahani, M., Gaeini, A. A., Afousi, A. G., & Fard, M. B. (2026) · Experimental Physiology · doi:10.1113/ep093527

BindingDB Entry 50019147: Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment.

BindingDB (2024) · UC San Diego · doi:10.7270/q2z03dds

The potential function and clinical application of FGF21 in metabolic diseases

Chen, Z., Yang, L., Liu, Y., Huang, P., Song, H., & Zheng, P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1089214 · Cited by 73

Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus

Dostálová, I., Haluzíková, D., & Haluzı́k, M. (2009) · Physiological Research · doi:10.33549/physiolres.931610 · Cited by 83

Metabolic actions of FGF21: molecular mechanisms and therapeutic implications

Ge, X., Wang, Y., Lam, K. S., & Xu, A. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.011 · Cited by 35

The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic

Geng, L., Lam, K. S. L., & Xu, A. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0386-0 · Cited by 607

FGF21: a novel prospect for the treatment of metabolic diseases.

Kharitonenkov, A., & Shanafelt, A. B. (2009) · PubMed · Cited by 91