Linking microbiota to human diseases: a systems biology perspective
Abstract
The human gut microbiota encompasses a densely populated ecosystem that provides essential functions for host development, immune maturation, and metabolism. Alterations to the gut microbiota have been observed in numerous diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), and irritable bowel syndrome, and some animal experiments have suggested causality. However, few studies have validated causality in humans and the underlying mechanisms remain largely to be elucidated. We discuss how systems biology approaches combined with new experimental technologies may disentangle some of the mechanistic details in the complex interactions of diet, microbiota, and host metabolism and may provide testable hypotheses for advancing our current understanding of human-microbiota interaction.
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Increasing culture-independent omic-based technologies have facilitated the discovery of novel functional dynamics of microbiota and their relationship with host pathophysiology.
“Increasing culture-independent omic-based technologies such as biomarker sequencing, metagenomics, metatranscriptomics, metaproteomics, and metabolomics have facilitated the discovery of novel functional dynamics of microbiota2, 3, 4, 5 and their relationship with host pathophysiology.6, 7, 8, 9”
From Regulation of Intestinal Barrier Function by Microbial Metabolites (2021) · cites this paper as [8]
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References 123 · Cited by 150
- Authors
- Wu, H., Tremaroli, V., & Bäckhed, F.
- Affiliations
- University of Gothenburg (SE)
- University of Copenhagen (DK)
- Corresponding author
- Bäckhed, Fredrik
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 26
- Issue
- 12
- Pages
- 758-770
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W2178518272
- Cited by
- 150
- References
- 123
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 9 · 2023: 10 · 2022: 7 · 2021: 20 · 2020: 11 · 2019: 10 · 2018: 26 · 2017: 19 · 2016: 25 · 2015: 1
- FWCI
- 2.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- gut microbiota, obesity, type 2 diabetes, irritable bowel syndrome, metabolic disorders, host metabolism, immune system maturation, systems biology
- MeSH terms
- Gastrointestinal Microbiome, Diabetes Mellitus, Type 2, Diet, Humans, Obesity, Systems Biology
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