Circadian Rhythms, Sleep, and Disorders of Aging
Open accessAbstract
Sleep-wake cycles are known to be disrupted in people with neurodegenerative disorders. These findings are now supported by data from animal models for some of these disorders, raising the question of whether the disrupted sleep/circadian regulation contributes to the loss of neural function. As circadian rhythms and sleep consolidation also break down with normal aging, changes in these may be part of what makes aging a risk factor for disorders like Alzheimer's disease (AD). Mechanisms underlying the connection between circadian/sleep dysregulation and neurodegeneration remain unclear, but several recent studies provide interesting possibilities. While mechanistic analysis is under way, it is worth considering treatment of circadian/sleep disruption as a means to alleviate symptoms of neurodegenerative disorders.
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There is accumulating evidence linking disrupted sleep and circadian rhythms to neurodegenerative disorders in humans and animal models.
“There is also accumulating evidence linking disrupted sleep and circadian rhythms to neurodegenerative disorders in humans and animal models235,236.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [235]
Older people (ages ~65 years and older) generally sleep less and have poorer sleep efficiency, increased night-time awakening, increased sleep latency and greater levels of daytime sleepiness.
“Older people (ages ~65 years and older) generally sleep less and have poorer sleep efficiency, increased night-time awakening, increased sleep latency and greater levels of daytime sleepiness234–236.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [235]
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References 146 · Cited by 369
- Authors
- Mattis, J., & Sehgal, A.
- Affiliations
- University of Pennsylvania (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Sehgal, Amita
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 27
- Issue
- 4
- Pages
- 192-203
- ISSN
- 1043-2760 (ISSN-L)
- PMC
- PMC4808513
- OpenAlex
- W2292489640
- Cited by
- 369
- References
- 146
- Citations by year
- 2026: 26 · 2025: 39 · 2024: 43 · 2023: 56 · 2022: 36 · 2021: 42 · 2020: 39 · 2019: 30 · 2018: 27 · 2017: 27 · 2016: 4
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Neurological Disorders and Stroke (R37NS048471)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- circadian rhythm, sleep, aging, neurodegenerative diseases, Alzheimer's disease, sleep-wake cycle disruption, circadian regulation, sleep consolidation, aging as risk factor, animal models of neurodegeneration
- MeSH terms
- Aging, Alzheimer Disease, Animals, Circadian Rhythm, Humans, Parkinson Disease, Sleep, Sleep Wake Disorders, Neurodegenerative Diseases, Chronobiology Disorders
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