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Cited by 15Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentEstrogen and related hormone effects

Emerging role of T3-binding protein μ-crystallin (CRYM) in health and disease

Aksoy, Osman, Hantusch, Brigitte, Kenner, Lukas·2022·Trends in Endocrinology & Metabolism
DOI 10.1016/j.tem.2022.09.003
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Abstract

Thyroid hormones are essential metabolic and developmental regulators that exert a huge variety of effects in different organs. Triiodothyronine (T3) and thyroxine (T4) are synthesized in the thyroid gland and constitute unique iodine-containing hormones that are constantly regulated by a homeostatic feedback mechanism. T3/T4 activity in cells is mainly determined by specific transporters, cytosolic binding proteins, deiodinases (DIOs), and nuclear receptors. Modulation of intracellular T3/T4 level contributes to the maintenance of this regulatory feedback. μ-Crystallin (CRYM) is an important intracellular high-affinity T3-binding protein that buffers the amount of T3 freely available in the cytosol, thereby controlling its action. In this review, we focus on the molecular and pathological properties of CRYM in thyroid hormone signaling, with emphasis on its critical role in malignancies.

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Authors
Aksoy, O., Hantusch, B., & Kenner, L.
Affiliations
  • Medical University of Vienna (AT)
  • University of Veterinary Medicine Vienna (AT)
ORCID
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2022-12
Volume
33
Issue
12
Pages
804-816
ISSN
1043-2760 (ISSN-L)
DOI
10.1016/j.tem.2022.09.003
OpenAlex
W4308207936
Cited by
15
References
4
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 2
FWCI
0.39
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
CRYM, triiodothyronine, thyroid hormone signaling, thyroid hormone transporters, deiodinases, thyroid hormone homeostasis, thyroid hormone resistance, thyroid cancer
MeSH terms
mu-Crystallins, Carrier Proteins, Crystallins, Humans, Thyroid Hormones, Thyroxine, Triiodothyronine

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