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Cited by 26Autophagy in Disease and TherapyMetabolism, Diabetes, and CancerGlycogen Storage Diseases and Myoclonus

Lysosomal glucose sensing and glycophagy in metabolism

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Mancini, Melina C., Noland, Robert C., Collier, J. Jason, Burke, Susan J., Stadler, Krisztian, Heden, Timothy D.·2023·Trends in Endocrinology & Metabolism
DOI 10.1016/j.tem.2023.07.008PMC PMC10592240
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Abstract

Lysosomes are cellular organelles that function to catabolize both extra- and intracellular cargo, act as a platform for nutrient sensing, and represent a core signaling node integrating bioenergetic cues to changes in cellular metabolism. Although lysosomal amino acid and lipid sensing in metabolism has been well characterized, lysosomal glucose sensing and the role of lysosomes in glucose metabolism is unrefined. This review will highlight the role of the lysosome in glucose metabolism with a focus on lysosomal glucose and glycogen sensing, glycophagy, and lysosomal glucose transport and how these processes impact autophagy and energy metabolism. Additionally, the role of lysosomal glucose metabolism in genetic and metabolic diseases will be briefly discussed.

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  1. [1]1. Lubke, T. ... Proteomics of the lysosome Biochim. Biophys. Acta. 2009; 1793:625-635 Crossref Scopus (202) PubMed Google Scholar
  2. [2]2. Lawrence, R.E. ∙ Zoncu, R. The lysosome as a cellular centre for signalling, metabolism and quality control Nat. Cell Biol. 2019; 21:133-142 Crossref Scopus (458) PubMed Google Scholar
  3. [3]3. Cui, W. ... Lipophagy-derived fatty acids undergo extracellular efflux via lysosomal exocytosis Autophagy. 2021; 17:690-705 Crossref Scopus (37) PubMed Google Scholar
  4. [4]4. Settembre, C. ... Signals from the lysosome: a control centre for cellular clearance and energy metabolism Nat. Rev. Mol. Cell Biol. 2013; 14:283-296 Crossref Scopus (1169) PubMed Google Scholar
  5. [5]5. Gu, X. ... SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway Science. 2017; 358:813-818 Crossref Scopus (327) PubMed Google Scholar
  6. [6]6. Wang, S. ... Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 Science. 2015; 347:188-194 Crossref Scopus (578) PubMed Google Scholar
  7. [8]8. Tsun, Z.Y. ... The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 Mol. Cell. 2013; 52:495-505 Full Text Full Text (PDF) Scopus (389) PubMed Google Scholar
  8. [10]10. Schulze, R.J. ... Breaking fat: the regulation and mechanisms of lipophagy Biochim. Biophys. Acta Mol. Cell Biol. Lipids. 2017; 1862:1178-1187 Crossref Scopus (150) PubMed Google Scholar
  9. [11]11. Sathyanarayan, A. ... ATGL promotes autophagy/lipophagy via SIRT1 to control hepatic lipid droplet catabolism Cell Rep. 2017; 19:1-9 Full Text Full Text (PDF) Scopus (211) PubMed Google Scholar
  10. [12]12. Heden, T.D. ... Regulation and role of glycophagy in skeletal muscle energy metabolism Autophagy. 2022; 18:1078-1089 Crossref Scopus (7) PubMed Google Scholar
  11. [13]13. Orozco, J.M. ... Dihydroxyacetone phosphate signals glucose availability to mTORC1 Nat. Metab. 2020; 2:893-901 Crossref Scopus (108) PubMed Google Scholar
  12. [14]14. Laqtom, N.N. ... CLN3 is required for the clearance of glycerophosphodiesters from lysosomes Nature. 2022; 609:1005-1011 Crossref Scopus (0) PubMed Google Scholar
  13. [15]15. Canibano-Fraile, R. ... Lysosomal glycogen accumulation in Pompe disease results in disturbed cytoplasmic glycogen metabolism J. Inherit. Metab. Dis. 2023; 46:101-115 Crossref Scopus (2) PubMed Google Scholar
  14. [16]16. Wu, L.X. ... Glycophagy mediated glucose-induced changes of hepatic glycogen metabolism via OGT1-AKT1-FOXO1(Ser238) pathway J. Nutr. Biochem. 2023; 117, 109337 Crossref Scopus (1) Google Scholar
  15. [17]17. Dong, J. ... Follicle-stimulating hormone alleviates ovarian aging by modulating mitophagy- and glycophagy-based energy metabolism in hens Cells. 2022; 11:3270 Crossref Scopus (2) PubMed Google Scholar
  16. [18]18. Fan, H. ... ROS generation attenuates the anti-cancer effect of CPX on cervical cancer cells by inducing autophagy and inhibiting glycophagy Redox Biol. 2022; 53, 102339 Crossref Scopus (9) Google Scholar
  17. [19]19. Conroy, L.R. ... Spatial metabolomics reveals glycogen as an actionable target for pulmonary fibrosis Nat. Commun. 2023; 14:2759 Crossref Scopus (2) PubMed Google Scholar
  18. [21]21. Sabatini, D.M. Twenty-five years of mTOR: uncovering the link from nutrients to growth Proc. Natl. Acad. Sci. U. S. A. 2017; 114:11818-11825 Crossref Scopus (332) PubMed Google Scholar
  19. [22]22. Herzig, S. ∙ Shaw, R.J. AMPK: guardian of metabolism and mitochondrial homeostasis Nat. Rev. Mol. Cell Biol. 2018; 19:121-135 Crossref Scopus (1795) PubMed Google Scholar
  20. [23]23. Ganley, I.G. ... ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy J. Biol. Chem. 2009; 284:12297-12305 Full Text Full Text (PDF) Scopus (1136) PubMed Google Scholar
  21. [24]24. Hosokawa, N. ... Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy Mol. Biol. Cell. 2009; 20:1981-1991 Crossref Scopus (1568) PubMed Google Scholar
  22. [25]25. Jung, C.H. ... ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery Mol. Biol. Cell. 2009; 20:1992-2003 Crossref Scopus (1568) PubMed Google Scholar
  23. [26]26. Kim, J. ... AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1 Nat. Cell Biol. 2011; 13:132-141 Crossref Scopus (4894) PubMed Google Scholar
  24. [27]27. Nazio, F. ... mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6 Nat. Cell Biol. 2013; 15:406-416 Crossref Scopus (588) PubMed Google Scholar
  25. [28]28. Yuan, H.X. ... Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy Autophagy. 2013; 9:1983-1995 Crossref Scopus (218) PubMed Google Scholar
  26. [29]29. Martina, J.A. ... MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB Autophagy. 2012; 8:903-914 Crossref Scopus (858) PubMed Google Scholar
  27. [30]30. Efeyan, A. ... Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival Nature. 2013; 493:679-683 Crossref PubMed Google Scholar
  28. [31]31. Almacellas, E. ... Phosphofructokinases axis controls glucose-dependent mTORC1 activation driven by E2F1 iScience. 2019; 20:434-448 Full Text Full Text (PDF) Scopus (24) PubMed Google Scholar
  29. [32]32. Roberts, D.J. ... Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition Mol. Cell. 2014; 53:521-533 Full Text Full Text (PDF) Scopus (220) PubMed Google Scholar
  30. [33]33. Lee, M.N. ... Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb Mol. Cell. Biol. 2009; 29:3991-4001 Crossref Scopus (146) PubMed Google Scholar
  31. [34]34. Sen, S. ... Glucose regulation of load-induced mTOR signaling and ER stress in mammalian heart J. Am. Heart Assoc. 2013; 2, e004796 Crossref Scopus (101) PubMed Google Scholar
  32. [35]35. Inoki, K. ... TSC2 mediates cellular energy response to control cell growth and survival Cell. 2003; 115:577-590 Full Text Full Text (PDF) Scopus (3086) PubMed Google Scholar
  33. [36]36. Gwinn, D.M. ... AMPK phosphorylation of raptor mediates a metabolic checkpoint Mol. Cell. 2008; 30:214-226 Full Text Full Text (PDF) Scopus (2910) PubMed Google Scholar
  34. [37]37. Kim, J. ... Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy Cell. 2013; 152:290-303 Full Text Full Text (PDF) Scopus (598) PubMed Google Scholar
  35. [38]38. Zhang, C.S. ... Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK Nature. 2017; 548:112-116 Crossref Scopus (388) PubMed Google Scholar
  36. [39]39. Li, M. ... Transient receptor potential V channels are essential for glucose sensing by aldolase and AMPK Cell Metab. 2019; 30:508-524.e512 Full Text Full Text (PDF) Scopus (69) PubMed Google Scholar
  37. [40]40. Zhang, C.S. ... The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism Cell Metab. 2014; 20:526-540 Full Text Full Text (PDF) PubMed Google Scholar
  38. [41]41. Greer, E.L. ... The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor J. Biol. Chem. 2007; 282:30107-30119 Full Text Full Text (PDF) Scopus (642) PubMed Google Scholar
  39. [42]42. Paquette, M. ... AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3 Autophagy. 2021; 17:3957-3975 Crossref Scopus (53) PubMed Google Scholar
  40. [44]44. Chang, C. ... AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation Mol. Cell. 2015; 60:930-940 Full Text Full Text (PDF) Scopus (199) PubMed Google Scholar
  41. [46]46. Gusarov, I. ... Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress Nat. Commun. 2017; 8:15868 Crossref Scopus (70) PubMed Google Scholar
  42. [47]47. Roig-Zamboni, V. ... Structure of human lysosomal acid alpha-glucosidase-a guide for the treatment of Pompe disease Nat. Commun. 2017; 8:1111 Crossref Scopus (150) PubMed Google Scholar
  43. [48]48. Coordinators, N.R. Database resources of the National Center for Biotechnology Information Nucleic Acids Res. 2013; 41:D8-D20 Crossref Scopus (410) PubMed Google Scholar
  44. [49]49. Szklarczyk, D. ... The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest Nucleic Acids Res. 2023; 51:D638-D646 Crossref Scopus (141) PubMed Google Scholar
  45. [50]50. Jiang, S. ... Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism J. Biol. Chem. 2010; 285:34960-34971 Full Text Full Text (PDF) Scopus (105) PubMed Google Scholar
  46. [51]51. Jiang, S. ... Starch binding domain-containing protein 1/genethonin 1 is a novel participant in glycogen metabolism J. Biol. Chem. 2011; 286, 39673 Full Text Full Text (PDF) Scopus (3) Google Scholar
  47. [52]52. Demetriadou, A. ... Mouse Stbd1 is N-myristoylated and affects ER-mitochondria association and mitochondrial morphology J. Cell Sci. 2017; 130:903-915 Crossref Scopus (22) PubMed Google Scholar
  48. [53]53. Jiang, S. ... Starch-binding domain-containing protein 1 (Stbd1) and glycogen metabolism: Identification of the Atg8 family interacting motif (AIM) in Stbd1 required for interaction with GABARAPL1 Biochem. Biophys. Res. Commun. 2011; 413:420-425 Crossref Scopus (136) PubMed Google Scholar
  49. [54]54. Sun, T. ... Starch binding domain-containing protein 1 plays a dominant role in glycogen transport to lysosomes in liver J. Biol. Chem. 2016; 291:16479-16484 Full Text Full Text (PDF) Scopus (31) PubMed Google Scholar
  50. [55]55. Pal, R. ... Abnormal glycogen storage in tuberous sclerosis complex caused by impairment of mTORC1-dependent and -independent signaling pathways Proc. Natl. Acad. Sci. U. S. A. 2019; 116:2977-2986 Crossref Scopus (12) PubMed Google Scholar
  51. [57]57. Yi, H. ... Stbd1 is highly elevated in skeletal muscle of Pompe disease mice but suppression of its expression does not affect lysosomal glycogen accumulation Mol. Genet. Metab. 2013; 109:312-314 Crossref Scopus (12) PubMed Google Scholar
  52. [58]58. Taylor, K.M. ... Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease PLoS One. 2013; 8, e56181 Google Scholar
  53. [59]59. Raben, N. ... Suppression of autophagy permits successful enzyme replacement therapy in a lysosomal storage disorder--murine Pompe disease Autophagy. 2010; 6:1078-1089 Crossref Scopus (123) PubMed Google Scholar
  54. [60]60. Nishino, I. ... Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease) Nature. 2000; 406:906-910 Crossref Scopus (756) PubMed Google Scholar
  55. [61]61. D'Souza, R.S. ... Danon disease: clinical features, evaluation, and management Circ. Heart Fail. 2014; 7:843-849 Crossref Scopus (138) PubMed Google Scholar
  56. [62]62. Zirin, J. ... Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy PLoS Biol. 2013; 11, e1001708 Crossref Scopus (83) PubMed Google Scholar
  57. [63]63. Lim, J.A. ... Modulation of mTOR signaling as a strategy for the treatment of Pompe disease EMBO Mol. Med. 2017; 9:353-370 Crossref Scopus (66) PubMed Google Scholar
  58. [64]64. Shemesh, A. ... Suppression of mTORC1 activation in acid-alpha-glucosidase-deficient cells and mice is ameliorated by leucine supplementation Am. J. Phys. Regul. Integr. Comp. Phys. 2014; 307:R1251-R1259 Crossref Scopus (0) PubMed Google Scholar
  59. [65]65. Lim, J.A. ... Defects in calcium homeostasis and mitochondria can be reversed in Pompe disease Autophagy. 2015; 11:385-402 Crossref Scopus (79) PubMed Google Scholar
  60. [66]66. Selak, M.A. ... Mitochondrial activity in Pompe's disease Pediatr. Neurol. 2000; 23:54-57 Full Text Full Text (PDF) Scopus (0) PubMed Google Scholar
  61. [67]67. Kondomerkos, D.J. ... Glycogen autophagy in the liver and heart of newborn rats. The effects of glucagon, adrenalin or rapamycin Histol. Histopathol. 2005; 20:689-696 PubMed Google Scholar
  62. [68]68. Kalamidas, S.A. ... The breakdown of glycogen in the lysosomes of newborn rat hepatocytes: the effects of glucose, cyclic 3',5'-AMP and caffeine Histol. Histopathol. 1994; 9:691-698 PubMed Google Scholar
  63. [69]69. Palmieri, M. ... Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways Hum. Mol. Genet. 2011; 20:3852-3866 Crossref Scopus (641) PubMed Google Scholar
  64. [70]70. Yan, B. ... The human acid alpha-glucosidase gene is a novel target of the Notch-1/Hes-1 signaling pathway J. Biol. Chem. 2002; 277:29760-29764 Full Text Full Text (PDF) Scopus (18) PubMed Google Scholar
  65. [71]71. Yan, B. ... Hes-1, a known transcriptional repressor, acts as a transcriptional activator for the human acid alpha-glucosidase gene in human fibroblast cells Biochem. Biophys. Res. Commun. 2002; 291:582-587 Crossref Scopus (0) PubMed Google Scholar
  66. [72]72. Doege, H. ... GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity J. Biol. Chem. 2000; 275:16275-16280 Full Text Full Text (PDF) Scopus (217) PubMed Google Scholar
  67. [73]73. Membrez, M. ... GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function Mol. Cell. Biol. 2006; 26:4268-4276 Crossref Scopus (50) PubMed Google Scholar
  68. [74]74. Gawlik, V. ... Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa Mol. Membr. Biol. 2008; 25:224-235 Crossref Scopus (41) PubMed Google Scholar
  69. [75]75. Carayannopoulos, M.O. ... GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst Proc. Natl. Acad. Sci. U. S. A. 2000; 97:7313-7318 Crossref Scopus (271) PubMed Google Scholar
  70. [76]76. Lisinski, I. ... Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells Biochem. J. 2001; 358:517-522 Crossref Scopus (105) PubMed Google Scholar
  71. [78]78. Mayeuf-Louchart, A. ... Glycogen dynamics drives lipid droplet biogenesis during brown adipocyte differentiation Cell Rep. 2019; 29:1410-1418.e1416 Full Text Full Text (PDF) Scopus (28) PubMed Google Scholar
  72. [79]79. Sarnat, H.B. ... Lipid storage myopathy in infantile Pompe's disease Arch. Neurol. 1982; 39:180-183 Crossref PubMed Google Scholar
  73. [80]80. Verity, M.A. Infantile Pompe's disease, lipid storage, and partial carnitine deficiency Muscle Nerve. 1991; 14:435-440 Crossref PubMed Google Scholar
  74. [81]81. Zheng, L. ... Prognostic significance of AMPK activation and therapeutic effects of metformin in hepatocellular carcinoma Clin. Cancer Res. 2013; 19:5372-5380 Crossref Scopus (180) PubMed Google Scholar
  75. [82]82. Yang, X. ... Predictive and preventive significance of AMPK activation on hepatocarcinogenesis in patients with liver cirrhosis Cell Death Dis. 2018; 9:264 Crossref Scopus (23) PubMed Google Scholar
  76. [83]83. Hsieh, F.S. ... Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner Mol. Oncol. 2017; 11:1035-1049 Crossref Scopus (0) PubMed Google Scholar
  77. [84]84. Lai, H.Y. ... Metformin resensitizes sorafenib-resistant HCC cells through AMPK-dependent autophagy activation Front. Cell Dev. Biol. 2020; 8, 596655 Google Scholar
  78. [85]85. Tseng, H.I. ... A novel AMPK activator shows therapeutic potential in hepatocellular carcinoma by suppressing HIF1alpha-mediated aerobic glycolysis Mol. Oncol. 2022; 16:2274-2294 Crossref Scopus (5) PubMed Google Scholar
  79. [86]86. Liu, Y. ... Inhibition of AMPK activity by TRIM11 facilitates cell survival of hepatocellular carcinoma under metabolic stress Clin. Transl. Med. 2021; 11, e617 Crossref Google Scholar
  80. [87]87. Zhu, Y. ... TRIM24 promotes hepatocellular carcinoma progression via AMPK signaling Exp. Cell Res. 2018; 367:274-281 Crossref Scopus (11) PubMed Google Scholar
  81. [88]88. Liu, Q. ... Glycogen accumulation and phase separation drives liver tumor initiation Cell. 2021; 184:5559-5576.e5519 Full Text Full Text (PDF) Scopus (77) PubMed Google Scholar
  82. [89]89. Favaro, E. ... Glucose utilization via glycogen phosphorylase sustains proliferation and prevents premature senescence in cancer cells Cell Metab. 2012; 16:751-764 Full Text Full Text (PDF) Scopus (278) PubMed Google Scholar
  83. [90]90. Tseng, Y.H. ... Use of an alpha-glucosidase inhibitor and the risk of colorectal cancer in patients with diabetes: a nationwide, population-based cohort study Diabetes Care. 2015; 38:2068-2074 Crossref Scopus (0) PubMed Google Scholar
  84. [91]91. Hamura, R. ... Suppression of lysosomal acid alpha-glucosidase impacts the modulation of transcription factor EB translocation in pancreatic cancer Cancer Sci. 2021; 112:2335-2348 Crossref Scopus (9) PubMed Google Scholar
  85. [92]92. Kraegen, E.W. ... Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats Am. J. Physiol. Endocrinol. Metab. 2006; 290:E471-E479 Crossref Scopus (102) PubMed Google Scholar
  86. [93]93. Khamzina, L. ... Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance Endocrinology. 2005; 146:1473-1481 Crossref Scopus (453) PubMed Google Scholar
  87. [94]94. Barbour, L.A. ... Chronically increased S6K1 is associated with impaired IRS1 signaling in skeletal muscle of GDM women with impaired glucose tolerance postpartum J. Clin. Endocrinol. Metab. 2011; 96:1431-1441 Crossref Scopus (34) PubMed Google Scholar
  88. [95]95. Kurowski, T.G. ... Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle Diabetes. 1999; 48:658-663 Crossref PubMed Google Scholar
  89. [96]96. Shah, O.J. ... Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies Curr. Biol. 2004; 14:1650-1656 Full Text Full Text (PDF) Scopus (679) PubMed Google Scholar
  90. [97]97. Shigeyama, Y. ... Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice Mol. Cell. Biol. 2008; 28:2971-2979 Crossref Scopus (149) PubMed Google Scholar
  91. [98]98. Yuan, T. ... Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes Diabetologia. 2017; 60:668-678 Crossref Scopus (74) PubMed Google Scholar
  92. [99]99. Rachdi, L. ... Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner Proc. Natl. Acad. Sci. U. S. A. 2008; 105:9250-9255 Crossref Scopus (169) PubMed Google Scholar
  93. [100]100. Ebato, C. ... Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet Cell Metab. 2008; 8:325-332 Full Text Full Text (PDF) Scopus (646) PubMed Google Scholar
  94. [101]101. Inoki, K. ... mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice J. Clin. Invest. 2011; 121:2181-2196 Crossref Scopus (443) PubMed Google Scholar
  95. [102]102. McCrimmon, A. ... Intact mitochondrial substrate efflux is essential for prevention of tubular injury in a sex-dependent manner JCI Insight. 2022; 7, e150696 Crossref Scopus (0) PubMed Google Scholar
  96. [103]103. Xiao, T. ... Rapamycin promotes podocyte autophagy and ameliorates renal injury in diabetic mice Mol. Cell. Biochem. 2014; 394:145-154 Crossref Scopus (73) PubMed Google Scholar
  97. [104]104. Zhou, X. ... PAN-AMPK activation improves renal function in a rat model of progressive diabetic nephropathy J. Pharmacol. Exp. Ther. 2019; 371:45-55 Crossref Scopus (12) PubMed Google Scholar
  98. [105]105. Douillard-Guilloux, G. ... Restoration of muscle functionality by genetic suppression of glycogen synthesis in a murine model of Pompe disease Hum. Mol. Genet. 2010; 19:684-696 Crossref Scopus (40) PubMed Google Scholar
  99. [106]106. Hamada, Y. ... The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice Metabolism. 2013; 62:734-742 Full Text Full Text (PDF) PubMed Google Scholar
  100. [107]107. Meneilly, G.S. ... Effect of acarbose on insulin sensitivity in elderly patients with diabetes Diabetes Care. 2000; 23:1162-1167 Crossref PubMed Google Scholar
  101. [109]109. Hui, K.S. ... The endocrine glands in Pompe's disease. Report of two cases Arch. Pathol. Lab. Med. 1985; 109:921-925 PubMed Google Scholar
  102. [110]110. Nannipieri, M. ... Influence of long-term diabetes on renal glycogen metabolism in the rat Nephron. 2001; 87:50-57 Crossref Scopus (34) PubMed Google Scholar
  103. [111]111. Pappa, E. ... Renal artery fibromuscular dysplasia in Pompe disease: a case report Mol. Genet. Metab. Rep. 2018; 16:64-65 Crossref Scopus (7) PubMed Google Scholar

Cited by

Sorted by citations

Authors
Mancini, M. C., Noland, R. C., Collier, J. J., Burke, S. J., Stadler, K., & Heden, T. D.
Affiliations
Pennington Biomedical Research Center (US)
Corresponding author
Heden, Timothy D.
ORCID
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2023-11
Volume
34
Issue
11
Pages
764-777
ISSN
1043-2760 (ISSN-L)
DOI
10.1016/j.tem.2023.07.008
PMC
PMC10592240
OpenAlex
W4386143111
Cited by
26
References
7
Citations by year
2026: 6 · 2025: 13 · 2024: 6 · 2023: 1
FWCI
1.02
Type
journal article
Language
en
Open access
Licence
Locations
  • Trends in Endocrinology and Metabolism (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Civil War Book Review (submittedVersion)
Funders
National Institutes of Health (R03 AI151920, L30 DK110338, R01 DK123183, K01 DK125258, P20 GM135002)
Topics
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
  • Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
Keywords
lysosomes, autophagy, energy metabolism, nutrient sensing, lysosomal metabolism, metabolic disorders
MeSH terms
Autophagy, Energy Metabolism, Glucose, Glycogen, Humans, Lysosomes

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