Metabolic control by AMPK in white adipose tissue
Open accessAbstract
White adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimulated glucose uptake, but AMPK-induced inhibition of β-adrenergic agonist-stimulated lipolysis might need to be re-evaluated in vivo. The lack of dramatic effects of AMPK activation on basal metabolism in WAT could be advantageous when treating type 2 diabetes with pharmacological pan-AMPK activators.
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AMPK is activated under low energy states, enhancing fat oxidation and reducing reliance on muscle protein for energy.
“Adenosine monophosphate-activated protein kinase (AMPK) is activated under low energy states, enhancing fat oxidation and reducing reliance on muscle protein for energy.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [84]
Genetic variations in AMPK subunit genes and epigenetic modifications affecting AMPK expression can influence the extent of this energy shift.
“Genetic variations in AMPK subunit genes (PRKAA1, PRKAA2) and epigenetic modifications affecting AMPK expression can influence the extent of this energy shift.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [84]
Increased AMPK activity enhances mitochondrial biogenesis, supporting sustained fat oxidation and muscle preservation under caloric deficit.
“Increased AMPK activity enhances mitochondrial biogenesis, supporting sustained fat oxidation and muscle preservation under caloric deficit [83,84].”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [84]
Individuals with high AMPK activation efficiently switch to fat as a fuel source, preserving muscle mass during restriction.
“Individuals with high AMPK activation efficiently switch to fat as a fuel source, preserving muscle mass during restriction.”
From Beyond Calories: Individual Metabolic and Hormonal Adaptations Driving Variability in Weight Management—A State-of-the-Art Narrative Review (2024) · cites this paper as [84]
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References 104 · Cited by 74
- Authors
- Göransson, O., Kopietz, F., & Rider, M. H.
- Affiliations
- Lund University (SE)
- de Duve Institute (BE)
- Corresponding author
- Göransson, Olga
- Venue
- Trends in Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2023-11
- Volume
- 34
- Issue
- 11
- Pages
- 704-717
- ISSN
- 1043-2760 (ISSN-L)
- OpenAlex
- W4386424700
- Cited by
- 74
- References
- 104
- Citations by year
- 2026: 22 · 2025: 35 · 2024: 16 · 2023: 1
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Trends in Endocrinology and Metabolism (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- AMPK, white adipose tissue, AMPK activators, lipogenesis, glucose uptake, lipolysis, beta-adrenergic agonists, type 2 diabetes, energy metabolism, triacylglycerol mobilization, free fatty acid oxidation
- MeSH terms
- Animals, Glucose, Humans, Lipolysis, Adipose Tissue, White, AMP-Activated Protein Kinases
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